Human Renal Cell Carcinoma in the Six Day Subrenal Capsule Assay

Weissglas, Max; Romijn, J. A.; Dongen, Jan Willem Van; Cappendijk, M.J.; Kate, Fiebo J. ten; Kurth, K. H.

doi:10.1016/s0022-5347(17)39006-7

Cited by 2 publications

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“…Da das biologische Wachstumsverhalten implantierter Tumorzellen stark variiert und letztlich nur ca. ein Drittel der Implantate sachgerecht ausgewertet werden kann, konnte sich diese aufwendige Methode für Routinetestungen nicht durchsetzen (1,153). Die Verwendung bei speziellen Fragestellungen wie z.B.…”

Section: Methoden Der Resistenztestungunclassified

Sensitivitätstestung oder Resistenztestung - Ein Unterschied?

Mickisch¹

1993

Aktuel Urol

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Section: Methoden Der Resistenztestungunclassified

Sensitivitätstestung oder Resistenztestung - Ein Unterschied?

Mickisch¹

1993

Aktuel Urol

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Use of animal models in diagnosis and treatment of renal cell carcinoma

et al. 1991

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This paper gives an overview of animal models available for the study of human renal cell carcinoma. Animal model systems can be divided into four categories: drug-induced tumors, virus-induced tumors, spontaneous tumors and human tumors transplanted into nude mice. Animal models have been used for improvement of diagnostic and therapeutic procedures. New markers for the diagnosis of more aggressive tumors can, for instance, be found by comparing metastatic with non-metastatic variants of the same primary tumor. Since advanced human renal cell carcinoma is refractory to chemotherapeutic agents, most therapeutic studies on animal models are immunotherapy studies. Combination treatment of biological-response modifiers such as interferon and tumor necrosis factor, with hyperthermia, bispecific monoclonal antibodies and high-energy shock waves, show promising results. Gene therapy will open new therapeutic possibilities.Renal cell cancer is relatively resistant to chemotherapy and hormone treatment, which makes it a candidate for alternative treatment such as immunotherapy [21]. The ultimate evaluation of any new therapeutic modalities will require careful randomized and controlled clinical studies. To define all therapeutic parameters and principles in human studies would be expensive and time-consuming and could involve ethical limitations [11]. No single animal model can mimic the human situation or give final answers; it can only provide approximations. Animal models representative for human cancer, however, have proven to be useful to test new therapeutic concepts. In this paper we will give an overview of the available animal model systems for renal cell carcinoma and indicate diagnostic and therapeutic studies possible in these models.Animal models offer many advantages, e.g., an unlimited number of cells and tumors is available to perform multiple and duplo experiments. Tumor lines can be exchanged among several laboratories, thereby allowing the study of identical material [14].Coffey et al. [11] define important factors that have to be controlled properly in animal models studies. These factors include: (1) uniformity of genetic strain and age of host, (2) controlled onset of tumor growth, (3) uniformity of tumor type, (4) precise knowledge of tumor load and growth rates, (5) regulation of dietary elements and physical stress, (6) total compliance with regard to drug intake and timing, (7) complete follow-up, (8) uniform control over onset and termination of the study and subject, with all subjects available for autopsy, (9) large numbers in each study group, all monitored at the same time, and (10) one observer making all evaluations. According to deVere White and Olsson, an ideal model for renal cell carcinoma should arise spontaneously, and have the histological characteristics of a pure adenocarcinoma, a predictable growth rate, the capacity to metastasize and the ability to grow without hormone dependence [52].In general, animal model systems can be divided into different categories: drug-induced tumo...

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Human Renal Cell Carcinoma in the Six Day Subrenal Capsule Assay

Cited by 2 publications

References 12 publications

Sensitivitätstestung oder Resistenztestung - Ein Unterschied?

Sensitivitätstestung oder Resistenztestung - Ein Unterschied?

Use of animal models in diagnosis and treatment of renal cell carcinoma

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