Human regulatory B cells control the T FH  cell response

Achour, Achouak; Simon, Quentin; Mohr, Audrey; Séïté, Jean-François; Youinou, Pierre; Bendaoud, Boutahar; Ghedira, Ibtissem; Pers, Jacques‐Olivier; Jamin, Christophe

doi:10.1016/j.jaci.2016.09.042

Cited by 72 publications

(78 citation statements)

References 51 publications

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“…Consistently, Achour et al. have further demonstrated that human Breg cells control Tfh cells maturation, expand Tfr cells, and inhibit Tfh cell–mediated antibody secretion . These observations highlight the pleiotropic functions of both Tfr and Tfh cells in the modulation of anti‐ and proatherosclerotic immune processes in an Apoe −/− mouse model.…”

Section: T and B Cells And Their Mutual Regulation In Atherosclerosissupporting

confidence: 53%

“…Its atheroprotective function is derived by its capacity to inhibit Tfh cells via TGF‐β secretion, its direct up‐regulation of lymphangiogenesis, and also by the creation of a positive loop between Tfr and Breg cells, itself a Tfr cell activator . In presence of Breg cells, the differentiation of CD4 + cells in Tfh cells during atherosclerosis is diminished and, in turn, Tfh cell population blocks Breg cells by secreting IL‐4 . IL‐4 cytokine is also important on the down‐regulation of lymphangiogenesis…”

Section: T and B Cells And Their Mutual Regulation In Atherosclerosismentioning

confidence: 99%

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Follicular regulatory T cell in atherosclerosis

Baptista

Mach

Brandt

2018

Journal of Leukocyte Biology

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Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.

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Section: T and B Cells And Their Mutual Regulation In Atherosclerosissupporting

confidence: 53%

Section: T and B Cells And Their Mutual Regulation In Atherosclerosismentioning

confidence: 99%

Follicular regulatory T cell in atherosclerosis

Baptista

Mach

Brandt

2018

Journal of Leukocyte Biology

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“…It has been recognized that Tregs plays an indispensable role in ICI resistance at the present stage [34]. Similarly to Tregs, a subset of B cells are identified as immune inhibitory cells which are termed Bregs [35]. Bregs could inhibit inflammation response by increasing the generation of PD-L1 and cytokines such as IL-10 [36,37].…”

Section: Regulatory Immune Cellsmentioning

confidence: 99%

The role of cancer-derived microRNAs in cancer immune escape

et al. 2020

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During malignant transformation, accumulated somatic mutations endow cancer cells with increased invasiveness and immunogenicity. Under selective pressure, these highly immunogenic cancer cells develop multiple strategies to evade immune attack. It has been well established that cancer cells could downregulate the expression of major histocompatibility complex, acquire alterations in interferon pathway, and upregulate the activities of immune checkpoint pathways. Besides, cancer cells secret numerous cytokines, exosomes, and microvesicles to regulate the functions and abundances of components in the tumor microenvironment including immune effector cells and professional antigen presentation cells. As the vital determinant of post-transcriptional regulation, microRNAs (miRNAs) not only participate in cancer initiation and progression but also regulate anti-cancer immune response. For instance, some miRNAs affect cancer immune surveillance and immune escape by interfering the expression of immune attack-associated molecules. A growing body of evidence indicated that cancer-derived immune modulatory miRNAs might be promising targets to counteract cancer immune escape. In this review, we summarized the role of some miRNAs in cancer immune escape and discussed their potential clinical application as treatment targets.

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“…Signals for Bregs activation include TLR and CD40 stimulation, BCR signaling, and CD80/CD86 expression. 31 These 43 (2) Bregs induce the conversion of naïve CD4 + T cells into FoxP3 + Tregs, which is mediated by TGF-secretion and cell-to-cell contact between T and B cells. 44 Bregs also directly induce the differentiation of Tregs, which may contribute to the global suppression of inflammatory responses.…”

Section: Regulatory B Cellsmentioning

confidence: 99%

The expanding family of noncanonical regulatory cell subsets

Zhao

Feng

Peng

et al. 2019

Journal of Leukocyte Biology

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The overwhelming body of research on regulatory lymphocytes has focused on CD4+ CD25+ Foxp3+ T cells (regulatory T cells); however, the last 5 years have witnessed inspiring progress in our understanding of regulatory B cells, regulatory CD8+ T cells, regulatory γδ cells, and, more recently, regulatory innate lymphoid cells(ILCregs). This review focuses on these so‐called noncanonical regulatory cell subsets. We primarily survey existing information on the phenotype, function, sustaining factors, and clinical value of the 4 best‐characterized non‐CD4 +Foxp3+ T regulatory cells. We then take a brief journey into the advances and challenges associated with next‐generation sequencing technologies and the application of sequencing to the study of noncanonical regulatory cell subsets.

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Human regulatory B cells control the T FH cell response

Cited by 72 publications

References 51 publications

Follicular regulatory T cell in atherosclerosis

Follicular regulatory T cell in atherosclerosis

The role of cancer-derived microRNAs in cancer immune escape

The expanding family of noncanonical regulatory cell subsets

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