Human RBP4 adipose tissue expression is gender specific and influenced by leptin

Kos, Katarina; Wong, Stephen; Tan, Bee K.; Kerrigan, David; Randeva, Harpal S.; Pinkney, Jonathan; Wilding, John

doi:10.1111/j.1365-2265.2010.03892.x

Cited by 32 publications

(27 citation statements)

References 35 publications

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“…On the contrary, higher levels of circulating RBP4 are described in men (35,37,65,67,72). This dimorphism was, however, not shown in all studies (32,73,84,85). Recently, higher RBP4 mRNA expression in adipose tissue was found in women when compared with men; this was, however, not reflected in the circulating levels (73).…”

Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 84%

“…In cell culture experiments, estradiol and not androgens, however, directly increases the RBP4 mRNA expression, protein levels, and secretion of RBP4 into the culture media (90). Recently, it was proposed that another sex-dimorphic adipokine leptin directly stimulates RBP4 expression in human adipocytes (73). RBP4 sex-specific dimorphism is also linked to iron metabolism.…”

Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 99%

“…Several studies found no correlation between circulating RBP4 levels, the level of obesity, and the amount and distribution of adipose tissue (9-11, 35, 72). In addition, several studies found no correlation between RBP4 adipose tissue mRNA expression and serum levels (9,10,44,73).…”

Section: Rbp4 In Childhood/adolescent Obesity and Insulin Resistancementioning

confidence: 99%

“…Namely, treatment of adipocytes from human visceral adipose tissue explants with increasing doses of recombinant leptin is associated with increased RBP4 protein expression (73).…”

Section: Studies On Human Adipocytesmentioning

confidence: 99%

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RBP4: a controversial adipokine

Kotnik

Fischer‐Posovszky

Wabitsch

2011

European Journal of Endocrinology

210

165

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Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.

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Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 84%

Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 99%

Section: Rbp4 In Childhood/adolescent Obesity and Insulin Resistancementioning

confidence: 99%

“…Namely, treatment of adipocytes from human visceral adipose tissue explants with increasing doses of recombinant leptin is associated with increased RBP4 protein expression (73).…”

Section: Studies On Human Adipocytesmentioning

confidence: 99%

See 2 more Smart Citations

RBP4: a controversial adipokine

Kotnik

Fischer‐Posovszky

Wabitsch

2011

European Journal of Endocrinology

210

165

View full text Add to dashboard Cite

show abstract

“…However, this regulation could differ in other tissues and be gender-dependent. In fact, many vitamin A metabolizing enzymes are expressed in a tissue-specific manner in males and females [34] by marginally understood mechanisms. Aldh1a2 expression appears to be regulated directly by estrogen receptor in its promoter region [35], whereas other Aldh1 enzyme levels are sensitive to sex-hormones by other, undefined mechanisms [36].…”

Section: Retinoid-dependent Regulation Of Specific Signaling and Tranmentioning

confidence: 99%

Vitamin A Metabolism: Challenges and Perspectives

Ziouzenkova¹

2012

Vitamin Trace Element

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Vitamins set an unprecedented example of the essential environment-gene interactions that are necessary to sustain life. Seventeen Nobel prizes were awarded in the last century for discoveries related to vitamins' structures, physiology, and functions [1]. These discoveries help to abolish diseases related to vitamin deficiencies in the developed world and offer solutions to eradicate these disorders worldwide [2]. For example, embryonic malformations, night blindness, and immune deficiency in children were effectively treated by vitamin A supplementation [2,3]. In spite of encouraging results in vitamin-deficient subjects, wide applications of vitamin supplements in the nutrient-sufficient populations have been partially discouraging. Many clinical and supplementation trials reported increased mortality in subjects on long-term lipophilic vitamin A and E supplementations [4,5]. Especially striking deleterious effects were reported for lipophilic vitamin A and provitamin A (β-carotene) [4,6]. The answer to safe application of lipophilic vitamins for the treatment and prevention of diseases may lie in the better understanding of their interaction with genes. There are two principal levels of lipophilic vitamin interactions with genes: 1) genes control metabolism of dietary vitamin into derivatives with hormone-like properties, and 2) vitamin-derived metabolites regulate specific gene programs through signaling and transcription pathways (Figure1).

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Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms

Blaner

2015

The Retinoids

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Human RBP4 adipose tissue expression is gender specific and influenced by leptin

Abstract: AT-derived RBP4-mRNA expression is gender specific and regulated by leptin. Circulating RBP4 levels appear to be independent of AT-RBP4 secretion.

Cited by 32 publications

References 35 publications

RBP4: a controversial adipokine

RBP4: a controversial adipokine

Vitamin A Metabolism: Challenges and Perspectives

Vitamin A Metabolism, Storage and Tissue Delivery Mechanisms

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