Human Protozoal Infections and Their Potential for Causing Neoplasms

Gupta, Raavi; Nowakowski, Maja; Haseeb, M. A.

doi:10.1007/978-3-319-20669-1_5

Cited by 1 publication

(4 citation statements)

References 107 publications

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“…2013; Gupta et al . 2015; Reddy and Fried, 2015); however, for certain parasites further evidence is required to elucidate cause-effect relationships (e.g. Machicado and Marcos, 2016).…”

Section: Pro- and Anti-tumourigenesis Associated With Eukaryotic Paramentioning

confidence: 99%

“…To the current knowledge, approximately half a dozen eukaryotic parasites are more or less directly associated with human carcinogenesis, including Platyhelminths, Nematoda and Protozoa (e.g. Benamrouz et al 2012;Oikonomopoulou et al 2013;Gupta et al 2015;Reddy and Fried, 2015); however, for certain parasites further evidence is required to elucidate cause-effect relationships (e.g. Machicado and Marcos, 2016).…”

Section: P R O -A N D a N T I -T U M O U R I G E N E S I S A S S O C mentioning

confidence: 99%

“…Several studies have provided evidence that certain eukaryotic parasites can promote oncogenesis and influence metastasis to distant tissues via various mechanisms (reviewed in Oikonomopoulou et al 2013Oikonomopoulou et al , 2014Gupta et al 2015;Tripathi et al 2015;Turhan et al 2015;Machicado and Marcos, 2016). Moreover, studies have shown that plasmodial infections may induce DNA damage and apoptosis inhibition, which led to the emergence and the progression of cancer, respectively (Carmen and Sinai, 2007;Kusi, 2013;Torgbor et al 2014;Robbiani et al 2015).…”

Section: Pro-carcinogenesis Role Of Malarial Infectionmentioning

confidence: 99%

“…Gupta et al . 2015; Reddy and Fried, 2015; Machicado and Marcos, 2016). Conversely, several reports indicate that pathogens, including eukaryotic parasites, may elicit anti-tumour immune responses that lead to protection against tumourigenesis (reviewed in Oikonomopoulou et al .…”

Section: Introductionmentioning

confidence: 99%

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Puzzling and ambivalent roles of malarial infections in cancer development and progression

Faure

2016

Parasitology

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Scientific evidence strongly suggests that parasites are directly or indirectly associated with carcinogenesis in humans. However, studies have also indicated that parasites or their products might confer resistance to tumour growth. Plasmodium protozoa, the causative agents of malaria, exemplify the ambivalent link between parasites and cancer. Positive relationships between malaria and virus-associated cancers are relatively well-documented; for example, malaria can reactivate the Epstein-Barr Virus, which is the known cause of endemic Burkitt lymphoma. Nevertheless, possible anti-tumour properties of malaria have also been reported and, interestingly, this disease has long been thought to be beneficial to patients suffering from cancers. Current knowledge of the potential pro- and anti-cancer roles of malaria suggests that, contrary to other eukaryotic parasites affecting humans, Plasmodium-related cancers are principally lymphoproliferative disorders and attributable to virus reactivation, whereas, similar to other eukaryotic parasites, the anti-tumour effects of malaria are primarily associated with carcinomas and certain sarcomas. Moreover, malarial infection significantly suppresses murine cancer growth by inducing both innate and specific adaptive anti-tumour responses. This review aims to present an update regarding the ambivalent association between malaria and cancer, and further studies may open future pathways to develop novel strategies for anti-cancer therapies.

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“…2013; Gupta et al . 2015; Reddy and Fried, 2015); however, for certain parasites further evidence is required to elucidate cause-effect relationships (e.g. Machicado and Marcos, 2016).…”

Section: Pro- and Anti-tumourigenesis Associated With Eukaryotic Paramentioning

confidence: 99%

Section: P R O -A N D a N T I -T U M O U R I G E N E S I S A S S O C mentioning

confidence: 99%

Section: Pro-carcinogenesis Role Of Malarial Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Puzzling and ambivalent roles of malarial infections in cancer development and progression

Faure

2016

Parasitology

View full text Add to dashboard Cite

show abstract

Human Protozoal Infections and Their Potential for Causing Neoplasms

Cited by 1 publication

References 107 publications

Puzzling and ambivalent roles of malarial infections in cancer development and progression

Puzzling and ambivalent roles of malarial infections in cancer development and progression

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