Human promoter CpG islands contain primate-specific repeats, cluster and resist reprogramming
K Naga Mohan,
Anuhya Anne,
Lov Kumar
et al.
Abstract:Imperfect tandem repeats (TRs) of greater than or equal to 400nt are associated with 365 human 5-prime genic CpG islands (TR-CGIs). Most are clustered at chromosome ends, with a high density across chromosome 19. These genes are enriched in neurodevelopmental/behavioral disorders and show interindividual variation in methylation levels. A subset of TR-CGIs is highly methylated and remains so during reprogramming to primed iPSCs, but become unmethylated in naive PSCs, as do imprinting control regions. Transcrip… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.