Human primary erythroid cells as a more sensitive alternative in vitro hematological model for nanotoxicity studies: Toxicological effects of silver nanoparticles

Rujanapun, Narawadee; Aueviriyavit, Sasitorn; Boonrungsiman, Suwimon; Rosena, Apiwan; Phummiratch, Duangkamol; Riolueang, Suchada; Chalaow, Nipon; Viprakasit, Vip; Maniratanachote, Rawiwan

doi:10.1016/j.tiv.2015.08.005

Cited by 10 publications

(14 citation statements)

References 44 publications

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“…Although many studies presented new nanoparticle surface treatments proving in vitro safety [271], others demonstrated the potential danger of such materials [276]. Nanoparticles have different effects on human health depending on the bulk material from which they have been produced [277].…”

Section: Protocol For Testing Of Silver Nanoparticle Coating Techmentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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Prosthetic joint infection (PJI) is a feared complication of total joint arthroplasty associated with increased morbidity and mortality. There is a growing body of evidence that bacterial colonization and biofilm formation are critical pathogenic events in PJI. Thus, the choice of biomaterials for implanted prostheses and their surface modifications may significantly influence the development of PJI. Currently, silver nanoparticle (AgNP) technology is receiving much interest in the field of orthopaedics for its antimicrobial properties and a strong anti-biofilm potential. The great advantage of AgNP surface modification is a minimal release of active substances into the surrounding tissue and a long period of effectiveness. As a result, a controlled release of AgNPs could ensure antibacterial protection throughout the life of the implant. Moreover, the antibacterial effect of AgNPs may be strengthened in combination with conventional antibiotics and other antimicrobial agents. Here, our main attention is devoted to general guidelines for the design of antibacterial biomaterials protected by AgNPs, its benefits, side effects and future perspectives in PJI prevention.

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Section: Protocol For Testing Of Silver Nanoparticle Coating Techmentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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“…There are about 3700 proteins in the complete plasma proteome (Lynch et al, 2007), and 50 of them have been found to be positively associated with foreign substances such as NPs (Aggarwal et al, 2009). Some studies also demonstrated that ambient particles and NPs are toxic to cytochromes P450, which is a ubiquitous superfamily of enzymes for eliminating most hydrophobic compounds in tissues throughout the body (Reed et al, 2015), as well as blood cells such as leukemic HL60 cells (Rodhe et al, 2015) and primary erythroid cells (Rujanapun et al, 2015). Foreign substances can be removed from the circulation through pores and fenestrae in the vascular endothelium.…”

Section: Introductionmentioning

confidence: 99%

PM2.5 Meets Blood: In vivo Damages and Immune Defense

Zhang

Kang

Chen

et al. 2018

Aerosol Air Qual. Res.

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Recent evidence shows that inhaled PM 2.5 can enter the blood circulatory system and even the brain. However, the damage of blood-borne PM 2.5 is not clearly elucidated. This work aims to understand and characterize the toxicity, i.e., the acute health effects, of PM 2.5 that is directly injected into the blood circulatory system. Rats were injected with different dosages (568, the equivalent of 1 year of inhalation for a rat; 93; and 9.3 µg) of PM 2.5 sampled from Beijing via a sterile catheter injected into the jugular vein. The behaviors of the rats upon external interruptions were recorded. Blood samples were collected before exposure and 1 h, 3 days, 5 days, 7 days, and 9 days after the PM 2.5 injection for analyzing serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), endotoxin, and 8-hydroxydeoxyguanosine (8-OHdG) levels. After euthanization, the heart, lung, liver, kidney, and spleen were taken and processed for histopathological analysis. PM 2.5 components were also analyzed. Acute inflammation with 102% and 90% increases for IL-6 and CRP, respectively, was observed 1 h after the 568 µg-PM 2.5 injection, while oxidative DNA damage occurred only five or more days later, which was accompanied by significantly elevated endotoxin levels. Hemorrhage of lung alveoli and behavioral changes, including fear and non-responsiveness, were also observed. Surprisingly, all exposed rats seemingly survived the PM 2.5 injection, behaving similarly to the control groups. The immune defense might have played an important role in combating the PM 2.5 injection. The results showed acute health effects from directly injected PM 2.5 , including rapid inflammation, oxidative damage, and routine-behavioral changes. Further study about the long-term effects of injection and the immune defense is warranted. Nonetheless, the results here suggest that PM 2.5 health effects may have to some extent been exaggerated in the literature.

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“…Ag‐based NSCs also have the potential to cause toxicity through the generation of reactive oxygen species (ROS) in the erythroid cell environment (Rujanapun et al ., ). ROS contribute to increased oxidative stress causing DNA damage, oxidized cellular proteins and subsequently result in endothelial dysfunction as well as organ damage (Patlolla et al ., ).…”

Section: Undesired Effects Of Nano‐sized‐constructs Toward the Circulmentioning

confidence: 97%

“…As discussed previously, platelet aggregation (Dobrovolskaia et al ., ; Ilinskaya & Dobrovolskaia, ; Radomski et al ., ) and vascular oxidative stress (Han et al ., ; Rujanapun et al ., ) are the most common side effects induced by NSCs. These events may lead to inflammatory responses, disproportionate production of ROS and thrombi formation in the vascular system (Han et al ., ; Radomski et al ., ).…”

Section: Telemetrymentioning

confidence: 99%

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

Cheah

Kiew

Lee

et al. 2017

J of Applied Toxicology

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While nano-sized construct (NSC) use in medicine has grown significantly in recent years, reported unwanted side effects have raised safety concerns. However, the toxicity of NSCs to the cardiovascular system (CVS) and the relative merits of the associated evaluation methods have not been thoroughly studied. This review discusses the toxicological profiles of selected NSCs and provides an overview of the assessment methods, including in silico, in vitro, ex vivo and in vivo models and how they are related to CVS toxicity. We conclude the review by outlining the merits of telemetry coupled with spectral analysis, baroreceptor reflex sensitivity analysis and echocardiography as an appropriate integrated strategy for the assessment of the acute and chronic impact of NSCs on the CVS.

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Human primary erythroid cells as a more sensitive alternative in vitro hematological model for nanotoxicity studies: Toxicological effects of silver nanoparticles

Cited by 10 publications

References 44 publications

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

PM2.5 Meets Blood: In vivo Damages and Immune Defense

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

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