Human Pluripotent Stem Cell Therapy for Huntington's Disease: Technical, Immunological, and Safety Challenges

Neural stem cell transplantation in central nervous system disorders

“…Once injected intraparenchymally (i.p.) BMP4, noggin, Notch, Jagged and Sonic Hedgehog) that are capable, on one hand, to recapitulate the microenvironment of the prototypical subventricular (SVZ) germinal niche [27,28,29 & , [78][79][80], and, on the other hand, to inhibit the NPC cell cycle by upregulating the expression of cell cycle-dependent kinase inhibitors [81]. or intrathecally (i.t.…”

The immunological challenges of cell transplantation for the treatment of Parkinson's disease

“…This is a major technical issue to overcome before practical translation into the clinic as a viable transplantation strategy in PD. Additionally, this method is technologically challenging and labor intensive due to quality control measures need for proper cell preparation [87]. Despite recent technological advancement with iPSC transplants [88], creating a safe individual cell graft for each PD patient will still be technically challenging due to the requirement of extensive laboratory and financial resources.…”

Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

“…Nowadays, a growing number of diseases can be improved via wide applications of stem cell transplantation, such as congenital cataract [12], diabetic retinopathy and keratopathy [13], myocardial infarction [14], ocular surface burns [15, 16], serious skin burns [17, 18], Parkinson's disease [19], Huntington's disease [20], and especially DFU [21]. Accumulating evidence has pointed out that mesenchymal stem cells (MSCs) may enhance wound healing [22–24] and be served as a cell source for many tissue engineering applications including bone regeneration [25], cartilage regeneration [26–28], myocardial regeneration [29], neurogenesis [30, 31], inflammatory bowel diseases [32], and DFU [33, 34].…”