Abstract:Background: Vaso-occlusive crisis (VOC) is a significant cause of morbidity and mortality in sickle cell disease (SCD) patients. As polymorphisms in human platelet antigens (HPA) exhibit a prothrombotic nature, we hypothesized that specific HPA polymorphisms could have a role in the pathogenesis of VOC in SCD. Aim of Study: This study investigated HPA-5 G1648A polymorphism among Egyptian SCD patients. Patients and Methods: This study included 100 SCD patients and 50 controls. Patients were divided into, VOC gr… Show more
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