Human Placental Lactogen in the Male Subject

Payne, Robert A.; Ryan, Robert J.

doi:10.1016/s0022-5347(17)60958-3

Cited by 20 publications

(4 citation statements)

References 13 publications

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“…'^ There have been few studies that have examined the value of hPL as a tumor marker for germ cell neoplasms.' 1,'2,15,'6, 21 Although an occasional patient may have hPL in his serum without detectable immunoreactive hCG, most of the studies have not demonstrated a clear advantage of hPL measurements in addition to hCG measurements over hCG measurements In order to clarify the relative merits of the various oncoplacental proteins as markers of disease activity in patients with nonseminomatous germ cell tumors, we measured AFP, hCG, SP1, and hPL in serial blood samples from patients with testicular tumors. In addition, we measured placental cystine aminopeptidase (oxytocinase) in the sera, since this protein is also of syncytiotrophoblast origin22 and, therefore, could potentially serve as a tumor marker for germ cell tumors of the testis.…”

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Trophoblastic proteins as tumor markers in nonseminomatous germ cell tumors

Braunstein

Thompson

Princler

et al. 1986

Cancer

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In order to examine the relative usefulness of measurements of oncoplacental proteins as tumor markers in patients with nonseminomatous germ cell tumors, the authors measured alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), pregnancy-specific beta,-glycoprotein (SPl), human placental lactogen (hPL), and placental cystine aminopeptidase (oxytocinase, CAP) in serial blood samples obtained from 26 men with these neoplasms. HCG and AFP were each elevated in 62% of the patients and both were elevated in 38%. SPl and hPL were increased in 31% and 12%, respectively. None of the patients had elevated CAP activity. Serum hCG and SPl concentrations were strongly correlated (r = 0.78, P < 0.001). No patient had an elevated SPl without a concomitant elevation in serum hCG. Serial measurements of hCG and SP1 indicated that they were concordant in five of the eight patients in whom both were elevated, and AFP and hCG were concordant in only one half of the ten patients in whom both markers were elevated. The number of patients with hPL elevations were too few for meaningful comparison of this marker with the others. These results indicate that measurements of SPl, hPL, and CAP do not provide additional useful information over that obtained from measurements of hCG and AFP in patients with nonseminomatous germ cell tumors.

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Trophoblastic proteins as tumor markers in nonseminomatous germ cell tumors

Braunstein

Thompson

Princler

et al. 1986

Cancer

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“…There are reports showing the presence of hCGlike material in tissues of normal human testes, colon, liver, gastric epithelium and pituitary [12][13][14][15]. With the exception of a single report by Payne and Ryan [16], who demonstrated hPL in apparently normal testes of a male with prostatic carcinoma, the associ ation of hPL with normal subjects has not yet been documented in the literature.…”

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confidence: 99%

Ectopic Human Placental Lactogen and β-Human Chorionic Gonadotropin in Gastric Fluid of Patients with Malignant and Non-Malignant Conditions of the Stomach

Shinde¹,

Adil²,

Sheth³

et al. 1981

Oncology

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Human placental lactogen (hPL) and β-human chorionic gonadotropin (β-hCG) in gastric aspirates and sera of 24 patients with malignant (12 patients) and non-malignant (12 patients) conditions of the stomach were studied. In patients with cancer of the stomach, hPL and β-hCGwere found to be present in gastric aspirate at higher frequency than in serum. The concentration of these hormones in gastric aspirate was higher than in serum. In 2 patients with duodenal ulcer β-hCGwas found to be present in gastric aspirate, 1 of them having the hormone in circulation as well, while none of the 12 patients with non-malignant conditions of the stomach showed presence of hPL in their gastric aspirate or serum.

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“…However, hCG has been detected in extracts of normal tissues, such as pituitary, testes, colon, liver and gastric epithelium (Braunstein et al, 1975;Vaitukaitis et al, 1976;Yoshimoto et al, 1977). Similar reports are not available with regard to hPL, except for one study by Payne & Ryan (1971), who showed the presence of hPL in apparently normal testes of a patient with carcinoma of the prostate. hPL is not known to be elaborated in various non-cancerous pathological conditions even at the low level of 2 pg/ml of serum (Weintraub & Rosen, 1971).…”

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confidence: 93%