Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis

Combe, Bernard; Cosso, B.; Clot, J; Bonneau, M.; Sany, J

doi:10.1016/0002-9343(85)90213-x

Cited by 56 publications

(9 citation statements)

References 20 publications

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“…In all these cases the immunoglobulin dose that was found to be effective was around 1-2 g/kg body weight. The mechanism of action of WIG is unknown yet, although several possibilities have been proposed including Fc-dependent mechanisms, interference with complement-mediated damage, modulation of cytokine secretion, and V region-dependent modulation of the expression of the autoimmune repertoire [8-161. Although there is less data on the effect of IVIG on T cell-mediated autoimmune diseases it seems to be advantageous also in multiple sclerosis [17,181, and in both the juvenile [19,201 and the adult variants of rheumatoid arthritis [21,22]. To understand better the mode of action of immunoglobulins in these disorders, we have studied their effect in the experimental animal model of adjuvant arthritis (AA).…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulins from rats that are resistant to adjuvant arthritis suppress the disease in arthritis‐susceptible rats

Ulmansky

Naparstek

1995

Eur J Immunol

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The therapeutic effect of high doses of polyclonal immunoglobulins has been well established in various B cell-associated autoimmune diseases. In the present work we have examined the effect of low doses of immunoglobulins in adjuvant arthritis, a T cell-associated disease in the Lewis rat. Lewis rats were treated with purified rat immunoglobulins as well as their Fc and F(ab')2 fragments and their protective effect on adjuvant arthritis was evaluated. We found that early as well as late treatment with low doses of rat immunoglobulins induced refractoriness to disease induction. The effect was found to be carried out by the F(ab')2 part of the immunoglobulins and could be adsorbed by affinity purification on Mycobacterium tuberculosis. The protective antibodies were present in Fisher and BN rats that are resistant to adjuvant arthritis, but not in the arthritis susceptible Lewis and Wistar strains. We suggest that resistance to autoimmune arthritis is associated with the presence of protective immunoglobulins and that their effect is carried out through the antigen recognition part of the molecule.

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Section: Introductionmentioning

confidence: 99%

Immunoglobulins from rats that are resistant to adjuvant arthritis suppress the disease in arthritis‐susceptible rats

Ulmansky

Naparstek

1995

Eur J Immunol

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“…Experiments performed using an inflammatory arthritis animal model showed that local injection of HPE reduced the symptoms of arthritis and the expression of inflammatory cytokines 7. In prior studies that were conducted, some patients with rheumatoid arthritis verified that placenta-eluted gamma globulins have a therapeutic effect 8,9. On the other hand, it is known that the placenta contains various growth factors such as hepatocyte growth factor (HGF), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), placenta growth factor (PlGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin like growth factor (IGF) and transforming growth factor (TGF) 2.…”

Section: Introductionmentioning

confidence: 96%

The Effect of Human Placental Extract on Rheumatoid Arthritis in an Animal Model

Park

Kim

et al. 2012

Ann Rehabil Med

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ObjectiveTo assess the efficacy of human placental extract (HPE) in an animal model of rheumatoid arthritis (RA).MethodWe used (i) KRN C57BL/6 TCR transgenic x NOD mice (KBx/N) serum transfer arthritis and (ii) collagen-induced arthritis (CIA) mice to evaluate the effi cacy of HPE (1 ul or 100 ul, intra-peritoneal, three times per week) on RA. Incidence, severity of arthritis, and hind-paw thickness were quantifi ed. Joint destruction was analyzed using modifi ed mammographic imaging. Histopathological analysis for inflammation, cartilage, and osteoclasts was performed using Hematoxylin-eosin (H-E), safranin-O, and tartrate-resistant acidic phosphatase (TRAP). ELISAs were used for detection of various cytokines in serum and joint tissue.ResultsThere were no significant differences in incidence of arthritis, clinical scores of arthritis, and hind-paw thickness between HPE-treated and vehicle-treated groups for up to 2 weeks in the KBx/N serum transfer arthritis model. Histopathological analysis also showed no differences 2 weeks after treatment. Levels of TNF-α, IL-1β, IL-6, IL-10, and RANKL in serum and joint tissues were similar in all groups. Furthermore, there were no differences in clinical, radiological, and histological parameters between HPE-treated and vehicle-treated group for 3 weeks in the CIA model.ConclusionSystemic treatment with HPE has no beneficial effects on arthritis in animal models of RA. Therefore, indiscreet use of HPE in RA should be forbidden.

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“…A French group evaluated the use of human placental-eluted IgG in 31 RA patients [21,22]. A dose of 1,500 mg administered intravenously daily for 1 week per month produced the best results.…”

Section: Case Reportmentioning

confidence: 99%

Use of autologous pregnancy plasma to treat a flare of juvenile rheumatoid arthritis: Case report and literature review

Wallace

Goldfinger

Klinenberg

1987

J of Clinical Apheresis

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Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis

Cited by 56 publications

References 20 publications

Immunoglobulins from rats that are resistant to adjuvant arthritis suppress the disease in arthritis‐susceptible rats

Immunoglobulins from rats that are resistant to adjuvant arthritis suppress the disease in arthritis‐susceptible rats

The Effect of Human Placental Extract on Rheumatoid Arthritis in an Animal Model

Use of autologous pregnancy plasma to treat a flare of juvenile rheumatoid arthritis: Case report and literature review

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