Human Peritoneal Mesothelial Cells Display Phagocytic and Antigen-Presenting Functions to Contribute to Intraperitoneal Immunity

Shaw, Tanya J.; Zhang, Xiang Y; Huo, Zhiming; Robertson, David; Lovell, Patricia A.; Dalgleish, Angus; Barton, Desmond P.J.

doi:10.1097/igc.0000000000000697

Cited by 19 publications

(21 citation statements)

References 16 publications

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“…Moreover, anionic sites at the glycocalyx ( Mutsaers et al, 1996 ) and adhesion molecules in microvilli of the mesothelial cell, change in response to pathogenic stimuli ( Jonjic et al, 1992 ; Liberek et al, 1996 ; Liang and Sasaki, 2000 ; Michailova, 2001 ; Bellingan et al, 2002 ; Herrick and Mutsaers, 2004 ; Susan and Tak Mao, 2012 ). The main adhesion molecules found in mesothelial cells are ICAM-1 and VCAM-1 ( Jonjic et al, 1992 ; Liberek et al, 1996 ; Liang and Sasaki, 2000 ; Boulanger et al, 2002 ; Cui et al, 2002 ), both increase expression when stimulated with pathogen related molecules ( Liang and Sasaki, 2000 ), INF-γ, ( Valle et al, 1995 ; Hausmann et al, 2000 ; Shaw et al, 2016 ) Il-1β, and TNF-α ( Jonjic et al, 1992 ; Liberek et al, 1996 ). These changes in adhesion molecules regulate leukocyte migration ( Jonjic et al, 1992 ; Liberek et al, 1996 ; Bellingan et al, 2002 ) and autophagy-mediated bacterial removal ( Wang J. et al, 2013 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Several findings suggest a possible AP function by the mesothelial cells ( Valle et al, 1995 ; Hausmann et al, 2000 ; Shaw et al, 2016 ). Major Histocompatibility Complex class II (MHC-II) is expressed by mesothelial cell in steady state ( Valle et al, 1995 ) and after IFN-γ stimulation ( Valle et al, 1995 ; Hausmann et al, 2000 ; Shaw et al, 2016 ). Accessory MHC-II molecules like ICAM-1 ( Jonjic et al, 1992 ; Liberek et al, 1996 ; Hausmann et al, 2000 ; Liang and Sasaki, 2000 ; Boulanger et al, 2002 ; Cui et al, 2002 ; Shaw et al, 2016 ), LFA-1 and low levels of B7-1 ( Shaw et al, 2016 ), have are also expressed by mesothelial cell.…”

Section: Resultsmentioning

confidence: 99%

“…Major Histocompatibility Complex class II (MHC-II) is expressed by mesothelial cell in steady state ( Valle et al, 1995 ) and after IFN-γ stimulation ( Valle et al, 1995 ; Hausmann et al, 2000 ; Shaw et al, 2016 ). Accessory MHC-II molecules like ICAM-1 ( Jonjic et al, 1992 ; Liberek et al, 1996 ; Hausmann et al, 2000 ; Liang and Sasaki, 2000 ; Boulanger et al, 2002 ; Cui et al, 2002 ; Shaw et al, 2016 ), LFA-1 and low levels of B7-1 ( Shaw et al, 2016 ), have are also expressed by mesothelial cell. Moreover, pure T-cell proliferation induction ( Valle et al, 1995 ; Hausmann et al, 2000 ; Shaw et al, 2016 ), and phagocytic activity by mesothelial cells have also been reported ( Valle et al, 1995 ; Hausmann et al, 2000 ; Wang J. et al, 2013 ; Shaw et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

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The Peritoneum: Beyond the Tissue – A Review

et al. 2018

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Background: Despite its complexity, the peritoneum is usually underestimated in classical medical texts simply as the surrounding tissue (serous membrane) of the gut. Novel findings on physiology and morphology of the peritoneum and mesothelial cell exist but they are usually focused or limited to Continuous Ambulatory Peritoneal Dialysis research and practice. This review aims to expose, describe and analyze the most recent evidence on the peritoneum’s morphology, embryology and physiology.Materials and Methods: A literature review was performed on Pubmed and MEDLINE. With no limit of publication date, original papers and literature reviews about the peritoneum, the peritoneal cavity, peritoneal fluid, and mesothelial cells were included (n = 72).Results: Peritoneum develops in close relationship to the gut from an early period in embryogenesis. Analyzing together the development of the primitive gut and the surrounding mesothelium helps understanding that the peritoneal cavity, the mesenteries and other structures can be considered parts of the peritoneum. However, some authors consider that structures like the mesenteries are different to the peritoneum. The mesothelial cell has a complex ultrastructural organization with intercellular junctions and apical microvilli. This complexity is further proven by the large array of functions like selective fluid and cell transport; physiological protective barrier; immune induction, modulation, and inhibition; tissue repair and scarring; preventing adhesion and tumoral dissemination; cellular migration; and the epithelial-mesenchymal transition capacity.Conclusion: Recent evidence on the anatomy, histology, and physiology of the peritoneum, shows that this structure is more complex than a simple serous membrane. These results call for a new conceptualization of peritoneum, and highlight the need of adequate research for identifying clinical relevance of this knowledge.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Peritoneum: Beyond the Tissue – A Review

et al. 2018

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“…In a cytology text published over 50 years ago, Spriggs and Boddington mentioned that mesothelial cells can show evidence of phagocytic activity . Although an occasional basic science paper has explored the phagocytic potential of mesothelial cells and a few reports of hemosiderin deposition in mesothelial cells in dogs or rats have since been published, the images of hemosiderin‐laden mesothelial cells from a human pericardial effusion shown and discussed here represent an underreported phenomenon.…”

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Hemosiderin‐laden mesothelial cells in a pericardial effusion

Marotti

Gutmann

2019

Diagnostic Cytopathology

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Emperipolesis of lymphocytes by mesothelial cells in pleural effusion involved by T‐lymphoblastic lymphoma

AbdullGaffar

2020

Diagnostic Cytopathology

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Emperipolesis is a physiologic or pathologic phenomenon characterized by the presence of intact viable cells within the cytoplasm of another cell. It has been described in normal tissues and in a variety of inflammatory and neoplastic lesions such as Rosai-Dorfman disease, tumors, hematopoietic disorders and rarely lymphomas. Emperipolesis by mesothelial cells is rare. Few cases of mesothelial emperipolesis of neoplastic lymphocytes in pleural effusions involved by lymphomas have been reported in the literature. Its etiopathogenesis and significance are controversial and speculative. We report a case of a 36-year-old man who presented with cough, chest pain, breathing difficulty, pericardial, and bilateral pleural effusions secondary to mediastinal T-lymphoblastic lymphoma. Pleural fluid cytology slides and cell block sections showed numerous single dispersed neoplastic lymphoblasts with occasional giant multinucleated mesothelial cells with emperipolesis of lymphocytes. The background showed scattered and clumped apoptotic karyorrhexis debris and reactive mesothelial cells. Cell block immunohistochemistry showed CD3, CD5, CD7, CD10, CD99, and TdT positive lymphocytes, consistent with involvement by T-lymphoblastic lymphoma. The giant cells were positive for cytokeratin, calretinin and WT1 confirming their mesothelial origin. Lymphoid effusions with emperipolesis may raise a potential diagnostic pitfall because they may morphologically be confused with other inflammatory and neoplastic lesions. This cell-in-cell phenomenon can be a helpful clue in the differential diagnosis of lymphocyte-rich effusions since it has been described in association with lymphomas. It might shed some light on the lymphocyte-mesothelial interaction and the potential phagocytic antigen-presenting properties of mesothelial cells under certain circumstances.

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Human Peritoneal Mesothelial Cells Display Phagocytic and Antigen-Presenting Functions to Contribute to Intraperitoneal Immunity

Abstract: ABSTRACT

Cited by 19 publications

References 16 publications

The Peritoneum: Beyond the Tissue – A Review

The Peritoneum: Beyond the Tissue – A Review

Hemosiderin‐laden mesothelial cells in a pericardial effusion

Emperipolesis of lymphocytes by mesothelial cells in pleural effusion involved by T‐lymphoblastic lymphoma

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