Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation

Induced Pluripotent Stem Cells and Hormesis

“…These responses will also be compared with hormetic responses from other stem cell types, principally various adult stem cells but also embryonic stem cells as well. 2 - 10 While the extent of the hormetic dose responses reported with IPSCs and their derived cells is modest at the present time, the findings are nonetheless important to report as a complement to extensive findings in other stem cells, especially those of adipose, bone marrow, embryonic and neural origin.…”

“…These values were within the range reported for the Hormetic Data Base 57 for a vast range of biological models, cell types, inducing agents and endpoints and consistent with hormetic responses reported in a broad range of adult and embryonic stem cells. 2-10 In studies using cells derived from IPSCs, the research that concerned hormesis had a considerably different focus than the papers published on hormesis and specific adult stem cells (adipose-derived stem cells (ADSCS), apical papilla (APSCs), bone marrow stem cells (BMSCs), dental pulp stem cells (DPSCs), embryonic stem cells (ESCs), endothelial stem cells, muscle stem cells (MSCs), neural stem cells (NSCs), and periodontal ligament stem cells (PDLSCs). In each of these adult stem cell papers, a major research theme was the evaluation of whether and to what extent each stem cell type could be induced to show cell proliferation/differentiation.…”

Hormesis and Endothelial Progenitor Cells

“…Hormetic dose responses have been now reported to be commonly reported for adipose derived stem cells (ADSCs), 45 apical papilla stem cells (APSCs), 46 bone marrow stem cells (BMSCs), 47 dental pulp stem cells (DPSCs), 48 embryonic stem cells (ESCs), 49 neuronal stem cells (NSCs), 50 and periodontal ligament stem cells (PDLSCs). 51 Based on the substantial occurrence of hormetic dose responses affecting cell viability, cell survival, cell proliferation, cell differentiation, and a capacity to enhance resilience to a broad spectrum of inflammatory conditions, a broad spectrum of stem cell types use adaptive strategies that conform to the quantitative features of the hormetic dose response, displaying a substantial degree of generality. However, despite these widespread occurrences of hormesis within the stem cell literature these findings are generally unrecognized as general dose response concept clinical implications.…”

Hormesis and Epidermal Stem Cells

“…Hormetic dose responses were reported in over 100 highly diverse chemical and physical agents with some common dietary supplements, such as resveratrol and EGCG, showing such biphasic dose responses in multiple stem cell types. 1-9 For example, resveratrol has been shown to induce hormetic effects in six stem cell types (eg, adipose, 1 bone, 62 embryonic, 3 endothelial, 8 muscle, 6 neural 2 ). These responses conform to the quantitative features of the hormetic dose response, findings that extend the generality of the hormesis concept.…”

“…Over the past year a series of papers have been published on the occurrence of hormesis with a broad spectrum of stem cells, including adipose, 1 neural, 2 embryonic, 3 dental pulp, 4 periodontal ligament, 5 muscle, 6 apical papilla, 7 endothelial progenitor cells, 8 and induced pluripotent stem cells (PSC). 9 The present paper represents an extension of this integrative, yet exploratory survey of hormesis and stem cells, with a focus on epidermal stem cells.…”