Human Periodontal Ligament Cell Response to a Newly Developed Calcium Phosphate–based Root Canal Sealer

Bae, Won Kyung; Chang, Seok Woo; Lee, Sang‐im; Kum, Kee‐Yeon; Bae, Kwang-Shik; Kim, Eun-Cheol

doi:10.1016/j.joen.2010.06.022

Cited by 52 publications

(46 citation statements)

References 38 publications

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“…In addition, during the cross-linking process of the polymer, the constituents continued to integrate into the network, resulting in less diffusion of leachable products out of the network. Based on the aforementioned factors, although the initial cytotoxicity of the extract was moderate, with time, the cytotoxicity is expected to reduce gradually (Schmalz 1994;Gomes et al 2001;Bae et al 2010).…”

Section: Resultsmentioning

confidence: 99%

A biocompatibility study of injectable poly(caprolactone-trifumarate) for use as a bone substitute material

Al-Namnam

Hwi

Chai

et al. 2015

Frontiers in Life Science

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The need for bone graft alternatives has led to the development of numerous bone graft substitutes. Here, the authors have synthesized a biodegradable poly(caprolactone-trifumarate) (PCLTF) polymer solution that could be injected into any bony defect. This polymer solution was synthesized using polycaprolactone-triol and fumaryl chloride (FCl). PCLTF is a multiple-branching, unsaturated and cross-linkable in situ material. The surface microstructure of PCLTF was investigated using a field emission scanning electron microscope. The incorporation of double bonds originating from FCl into the poly(caprolactone) backbone was confirmed in the Fourier transform infrared spectra. The in vitro cytotoxic effects of PCLTF, its leachable extracts and degradation products were evaluated in direct and indirect contact tests against human oral fibroblasts. Cell viability was evaluated using the microculture tetrazolium assay and cytotoxicity evaluations of PCLTF were tested in accordance with ISO 10993-5 standards. The results showed that there was evidence of reasonable cell growth, good cell viability and intact cell morphology after exposure to PCLTF, its extracts and degradation products. There was no evidence of critical cytotoxic effects.

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Section: Resultsmentioning

confidence: 99%

A biocompatibility study of injectable poly(caprolactone-trifumarate) for use as a bone substitute material

Al-Namnam

Hwi

Chai

et al. 2015

Frontiers in Life Science

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“…In other words, we made 5 samples of ProRoot MTA and another 5 samples for Ortho MTA for heavy metal analysis, whereas in previous studies the experiment was performed with only 3 replicates (20,37). Considering that the increasing sample size could reduce the risk of incorporating bias into the data, our results could be considered to give more solid evidence than in previous studies (12)(13)(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 95%

“…In addition, there are studies that reported the sealing ability or biocompatibility of MTA as endodontic sealers (8)(9)(10)(11)(12)(13)(14). Furthermore, as was suggested in the recent review article by Parirokh and Torabinejad (1), various biomaterials with biological activities similar to those of MTA, such as Bioaggregate (Innovative Bioceramix, Vancouver, BC, Canada) (15) and MTA Angelus (Angelus, Londrina, PR, Brazil) (16), have been introduced and have shown good biocompatibilities and sealing abilities.…”

mentioning

confidence: 99%

Heavy Metal Analysis of Ortho MTA and ProRoot MTA

Chang

Baek

Yang

et al. 2011

Journal of Endodontics

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“…Capseal is one of the ex- 10) . Capseal was reported to have good root canal sealing ability 11) and biocompatibility [12][13][14] in previous studies.…”

Section: Introductionmentioning

confidence: 94%

Study on Biocompatibility and Mineralization Potential of Capseal

Bae¹,

Chang²,

Kum³

et al. 2014

Journal of Korean Dental Science

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cc This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose: Capseal I and Capseal II are calcium silicate and calcium phosphate based experimental root canal sealers.This study sought to evaluate the biocompatibility and mineralization potential of Capseal I and Capseal II. Materials and Methods: The biocompatibility and mineralization related gene expression (alkaline phosphatase[ALP], bone sialoprotein [BSP], and osteocalcin) of Capseal I and Capseal II were compared using methylthiazol tetrazolium assay and reverse transcription-polymerization chain reaction analysis, respectively. The results were analyzed by Kruskal-Wallis test. A P-value of <0.05 was considered signifi cant. Result: Both Capseal I and Capseal II were favorable in terms of biocompatibility, infl uencing the messenger RNA expression of ALP and BSP. Conclusion: Within the limitation of this study, Capseal is biocompatible, with mineralization promoting potential; thus, it could be a promising root canal sealer.

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Human Periodontal Ligament Cell Response to a Newly Developed Calcium Phosphate–based Root Canal Sealer

Cited by 52 publications

References 38 publications

A biocompatibility study of injectable poly(caprolactone-trifumarate) for use as a bone substitute material

A biocompatibility study of injectable poly(caprolactone-trifumarate) for use as a bone substitute material

Heavy Metal Analysis of Ortho MTA and ProRoot MTA

Study on Biocompatibility and Mineralization Potential of Capseal

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