Human pegivirus 1 infection in lung transplant recipients: Prevalence, clinical relevance and kinetics of viral replication under immunosuppressive therapy

Graninger, Marianne; Aberle, Stephan W.; Görzer, Irene; Jaksch, Péter; Puchhammer‐Stöckl, Elisabeth

doi:10.1016/j.jcv.2021.104937

Cited by 6 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since HPgV-1 is known to cause chronic infections, HPgV-1 detection at multiple consecutive time-points in most patients suggests sustained viremia despite the long intervals between the sampling time-points. Besides a possible association with lymphoma, HPgV-1 has not been associated with any overt clinical manifestations after transplantation, despite complex interactions with the immune system [4,[24][25][26][27][28][29]. Although lacking statistical significance, higher rates of progression-free survival and GVHD-free relapse-free survival, and lower aGVHD of grade ≥2 and relapse, have been reported among HPgV-1-infected versus HPgV-1-negative patients, illustrating that HPgV-1 may not be a silent bystander [3].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Detection of Twenty DNA and RNA Viruses in Allogeneic Hematopoietic Stem Cell Transplant Recipients Plasma

Zanella

Hosszu-Fellous

et al. 2023

Viruses

View full text Add to dashboard Cite

Metagenomics revealed novel and routinely overlooked viruses, representing sources of unrecognized infections after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We aim to describe DNA and RNA virus prevalence and kinetics in allo-HSCT recipients’ plasma for one year post HSCT. We included 109 adult patients with first allo-HSCT from 1 March 2017 to 31 January 2019 in this observational cohort study. Seventeen DNA and three RNA viral species were screened with qualitative and/or quantitative r(RT)-PCR assays using plasma samples collected at 0, 1, 3, 6, and 12 months post HSCT. TTV infected 97% of patients, followed by HPgV-1 (prevalence: 26–36%). TTV (median 3.29 × 105 copies/mL) and HPgV-1 (median 1.18 × 106 copies/mL) viral loads peaked at month 3. At least one Polyomaviridae virus (BKPyV, JCPyV, MCPyV, HPyV6/7) was detected in >10% of patients. HPyV6 and HPyV7 prevalence reached 27% and 12% at month 3; CMV prevalence reached 27%. HSV, VZV, EBV, HHV-7, HAdV and B19V prevalence remained <5%. HPyV9, TSPyV, HBoV, EV and HPg-V2 were never detected. At month 3, 72% of patients had co-infections. TTV and HPgV-1 infections were highly prevalent. BKPyV, MCPyV and HPyV6/7 were frequently detected relative to classical culprits. Further investigation is needed into associations between these viral infections and immune reconstitution or clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Longitudinal Detection of Twenty DNA and RNA Viruses in Allogeneic Hematopoietic Stem Cell Transplant Recipients Plasma

Zanella

Hosszu-Fellous

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…All anelloviruses infecting an individual contribute to their personal “anellome”, which is relatively stable over time [ 3 ]. Increased concentrations of anelloviruses are found in the blood of people with immune disorders [ 8 , 9 , 10 , 11 , 12 ], indicating an interplay between anelloviruses and the host’s immune defence. However, little is known about the exact interaction between host immunity and anelloviruses.…”

Section: Introductionmentioning

confidence: 99%

The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses

Timmerman,

Commandeur,

Deijs

et al. 2024

Viruses

View full text Add to dashboard Cite

Members of the Anelloviridae family dominate the blood virome, emerging early in life. The anellome, representing the variety of anelloviruses within an individual, stabilizes by adulthood. Despite their supposedly commensal nature, elevated anellovirus concentrations under immunosuppressive treatment indicate an equilibrium controlled by immunity. Here, we investigated whether anelloviruses are sensitive to the immune activation that accompanies a secondary infection. As a model, we investigated 19 health care workers (HCWs) with initial SARS-CoV-2 infection, with blood sampling performed pre and post infection every 4 weeks in a 3-month-follow-up during the early 2020 COVID-19 pandemic. A concurrently followed control group (n = 27) remained SARS-CoV-2-negative. Serum anellovirus loads were measured using qPCR. A significant decrease in anellovirus load was found in the first weeks after SARS-CoV-2 infection, whereas anellovirus concentrations remained stable in the uninfected control group. A restored anellovirus load was seen approximately 10 weeks after SARS-CoV-2 infection. For five subjects, an in-time anellome analysis via Illumina sequencing could be performed. In three of the five HCWs, the anellome visibly changed during SARS-CoV-2 infection and returned to baseline in two of these cases. In conclusion, anellovirus loads in blood can temporarily decrease upon an acute secondary infection.

show abstract

“…Because higher anellovirus titers are found in immunocompromised patients ( 25 – 28 ), it is likely that anellovirus loads are partly regulated by the host immune system. Recent findings based on AnelloScan (T7 phage display anellovirus peptide library immunoprecipitation assay) showed that anellovirus proteins elicit varied antibody reactivity ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

Control of Human Anelloviruses by Cytosine to Uracil Genome Editing

Timmerman

Kaczorowska

Deijs

et al. 2022

mSphere

View full text Add to dashboard Cite

Despite significant attention on anellovirus research, the interaction between the anellovirus virome and the human host remains unknown. We show the dynamics of APOBEC3-mediated cytidine deaminase activity on anelloviruses during a 30-year period of chronic infection and postulate that this antiviral mechanism controls anelloviruses. These results expand our knowledge of anellovirus-host interactions, which may be important for the design of gene therapies.

show abstract

Human pegivirus 1 infection in lung transplant recipients: Prevalence, clinical relevance and kinetics of viral replication under immunosuppressive therapy

Cited by 6 publications

References 39 publications

Longitudinal Detection of Twenty DNA and RNA Viruses in Allogeneic Hematopoietic Stem Cell Transplant Recipients Plasma

Longitudinal Detection of Twenty DNA and RNA Viruses in Allogeneic Hematopoietic Stem Cell Transplant Recipients Plasma

The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses

Control of Human Anelloviruses by Cytosine to Uracil Genome Editing

Contact Info

Product

Resources

About