Human patient derived organoids: an emerging precision medicine model for gastrointestinal cancer research
Sicheng Yan,
Yuxuan He,
Yuehong Zhu
et al.
Abstract:Gastrointestinal cancers account for approximately one-third of the total global cancer incidence and mortality with a poor prognosis. It is one of the leading causes of cancer-related deaths worldwide. Most of these diseases lack effective treatment, occurring as a result of inappropriate models to develop safe and potent therapies. As a novel preclinical model, tumor patient-derived organoids (PDOs), can be established from patients’ tumor tissue and cultured in the laboratory in 3D architectures. This 3D mo… Show more
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