Human parvovirus PARV4 in plasma pools of Chinese origin

Ma, Yuyuan; Guo, Yesong; Zhou, Xiong; Wang, Z.; Lv, Meng; Yan, Qiulin; Zhang, J.-G.

doi:10.1111/j.1423-0410.2012.01605.x

Cited by 20 publications

(21 citation statements)

References 10 publications

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“…The overall frequency (2.52%) of PARV4 viraemia observed in our study is in fairly good agreement with most previous results (0 to 5% in plasma from healthy blood donors) conducted in other areas of the world [10], [12], [16], [28], [29]. However, there are significant differences between our data and that reported in a recent, similar study in Shanghai [27] by Yu et al , in which the PARV4 was the only parvovirus detected and its infection rate was strikely high as 16–22%, 33% and 41% in healthy controls, HCV infected and HBV infected subjects respectively, comparing to previous reports published [8]–[10], [12], [13], [16], [29], [30].…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Human Parvovirus B19, Bocavirus, and PARV4 in Blood Samples from the General Population of China and Lack of a Correlation between Parvovirus and Hepatitis B Co-Infection

et al. 2013

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Few comprehensive studies have investigated viraemia caused by human parvoviruses (HPAVs) in China. A total of 1626 of blood samples were collected from non-HBV and HBV infected Chinese subjects (adults, N = 1279; children, N = 347) from south-western and south-eastern China. DNA from three HPAVs was detected in blood samples using PCR-based assays. The epidemiological profiles and association with HBV co-infection were also analysed. Of the 1626 blood samples tested, 138 (8.49%) were found to exhibit HPAV viraemia, including 3.51% with B19, 3.75% with HBoV and 2.52% with PARV4. The presence of B19 DNA in both child and adult, as well as that of PARV4 DNA in adult,from the south-western region was significantly higher than that from the south-eastern region (P = 0.006 for B19 in children; P = 0.026 for B19 in adults; and P = 0.014 for PARV4 in adult).However, the frequency of HBoV DNA in adults from the south-western region was significantly lower than that observed in adults from the south-eastern region (P = 0.001). Furthermore, HBoV was more prevalence in male (4.9%) than in female (1.4%) individuals. In addition, no significant correlation between HBV and HPAV co-infection was found using serum samples from Chinese adults. In conclusions,the molecular prevalence of three HPAVs in blood samples exhibited variation among different populations depending on area, age and gender; No association between HPAV and HBV infection in adults was found. Our data provide a basis for improving blood safety and preventing HPAV infection in China.

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Section: Discussionsupporting

confidence: 93%

Prevalence of Human Parvovirus B19, Bocavirus, and PARV4 in Blood Samples from the General Population of China and Lack of a Correlation between Parvovirus and Hepatitis B Co-Infection

et al. 2013

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“…Previous findings have suggested parenteral acquisition of PARV4 infections [8,[21][22][23]. However, our current study, taken with similar studies showing 26.15% (51/195) of lots of source plasma pools from healthy donors in Beijing were positive for PARV4 [24] and 16.7% to 17.6% PARV4 IgM seropositivity in healthy adults in Taiwan [25] suggest that PARV4 may be transmitted through non-parenteral routes. Similar PARV4 prevalence has also been reported from Africa [26,27]; importantly, there was no parenteral risk in either of the African studies, further supporting this idea.…”

Section: Discussioncontrasting

confidence: 66%

PARV4 Co-Infection is Associated with Disease Progression in HBV Patients in Shanghai.

Wang

Zhao

et al. 2015

J Med Diagn Meth

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Human parvovirus 4 (PARV4) has been detected in blood and tissue samples from HIV/AIDS patients who are injecting drug users and we have reported PARV4 co-infection of hepatitis B or hepatitis C virus (HBV, HCV) infected individuals. In this study, we have investigated the consequences of co-infection with PARV4 for HBV infected individuals.The aim of this study was to investigate the consequences of co-infection with PARV4 for HBV infected individuals.Serum samples from healthy controls and HBV infected subjects were retrieved from Shanghai Center for Disease Control and Prevention Sample Bank. HBV genotypes were determined and sequences compared with reference sequences to derive phylogeny trees. All samples were tested for PARV4, parvovirus B19 and HCV; serum alanine transaminase (ALT) in chronic HBV patients was used as an indicator of disease severity. Relevant cytokines were measured in sera from healthy controls and HBV carriers.HBV infected subjects had higher prevalence of PARV4 compared to healthy controls. PARV4 prevalence was not associated with HBV genotype, negatively correlated with serum HBV DNA, but positively correlated with serum ALT level. Additionally, serum IL-8 was up-regulated in HBV carriers co-infected with PARV4.Co-infection with PARV4 may increase the risk of liver disease in HBV patients through up-regulation of inflammatory cytokines, but the underlying mechanism remains to be elucidated.

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“…So far, the virus has been isolated from many tissues including bone marrow of HIV-positive individuals (13) and the liver of HBVand HCV-infected patients (14,15). Moreover, the virus has been diagnosed in plasma, cerebrospinal fluid (CSF), skin, myocardium, and blood products around the world (1,3,7,8,11,(15)(16)(17). Despite the detection of viral nucleic acid in many organs, PARV4 has scarcely been linked to specific symptoms, except for a recent study that was conducted in Africa linking PARV4 to encephalitis (11) and another study in which the virus was diagnosed in people with symptoms including pharyngitis, nausea, and joint pain (1).…”

Section: Introductionmentioning

confidence: 99%

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

et al. 2017

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Background/aim: PARV4, a small DNA virus belonging to the family Parvoviridae, was first isolated in an HBV injecting drug user. Several studies have investigated PARV4 co-infection with HBV and HCV and its effect on the progression of liver disease. The aim of this study was to determine the frequency of PARV4 among HBV-infected patients and healthy individuals. Materials and methods:A group of 90 HBV patients and a group of 90 healthy subjects were included in this study. Samples were selected after screening tests such as HBsAg ELISA, anti-HCV ELISA, and anti-HIV ELISA. Nested-PCRs were conducted to detect the PARV4 genome. Positive samples were then subjected to DNA sequencing.Results: PARV4 DNA was detected in 4.4% of HBV patients in comparison with 1.1% of healthy individuals (P-value: 0.36). DNA sequencing results revealed that PARV4 in all five positive samples was genotype I.Conclusions: Although this pilot study showed no significant difference between the frequency of PARV4 among HBV patients and healthy donors, further studies with a larger sample size are suggested to determine the association of PARV4 with HBV co-infection and the impact of this virus on the progression of liver disease in patients with hepatitis B.

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Human parvovirus PARV4 in plasma pools of Chinese origin

Cited by 20 publications

References 10 publications

Prevalence of Human Parvovirus B19, Bocavirus, and PARV4 in Blood Samples from the General Population of China and Lack of a Correlation between Parvovirus and Hepatitis B Co-Infection

Prevalence of Human Parvovirus B19, Bocavirus, and PARV4 in Blood Samples from the General Population of China and Lack of a Correlation between Parvovirus and Hepatitis B Co-Infection

PARV4 Co-Infection is Associated with Disease Progression in HBV Patients in Shanghai.

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

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