Human parvovirus B19 infection mimicking systemic lupus erythematosus

Saeki, Takako; Shibuya, Masako; Sawada, H.; Miyamura, Syouji; Nakano, Masaaki; Gejyo, Fumitake; Arakawa, Masaaki

doi:10.3109/s10165-001-8061-3

Cited by 12 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypocomplementaemia has been suggested as an early marker for parvovirus infection and our patient had reduced values of both C3 and C4, showing a classical pathway activation similar to systemic lupus erythematosus (SLE) disease and present in some cases of postinfectious glomerulonephritis 13. This has been described previously in literature and can be associated with both renal injury and arthralgia 14–16…”

Section: Discussionsupporting

confidence: 74%

Parvoviral infection with systemic impact and renal consequences

Mira¹,

Marques

Sousa

et al. 2019

BMJ Case Rep

View full text Add to dashboard Cite

Parvovirus infection is usually asymptomatic especially in immunocompetent adults. When symptomatic it can range from mild to life threatening depending on the patient’s age and comorbidities. We report a case of a 40-year-old male patient with parvovirus infection who presented a purpuric rash in distal extremities, acute kidney injury, type II mixed cryoglobulinaemia and hypocomplementaemia. His renal biopsy showed a mesangioproliferative glomerulonephritis with positive immunoreactivity to C3, IgM and C1q. Parvovirus B19 was detected in the biopsy tissue by PCR. He was treated with prednisolone with total remission after 1 month. We discuss the diagnosis of kidney lesion due to parvovirus in an immunocompetent person, which is a very rare condition and its association with the cryoglobulinaemia diagnosis.

show abstract

Section: Discussionsupporting

confidence: 74%

Parvoviral infection with systemic impact and renal consequences

Mira¹,

Marques

Sousa

et al. 2019

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…Patients with SLE can also develop hypocomplementemia because of bacterial and viral infections. 13 In our case, the causative bacteria were not identified in blood culture. However, Fusobacterium necrophorum , a causative agent of Lemierre syndrome, is known to decrease C3 by binding to the inhibiting factor H. 14 In the present case and two of the four previously reported cases, C3 and C4 levels were decreased at the onset of Lemierre syndrome.…”

Section: Discussionmentioning

confidence: 51%

A case of Lemierre syndrome combined with a suspected systemic lupus erythematosus flare

Fujii

Iwabuchi

Moriyama

et al. 2019

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Lemierre syndrome develops in healthy young patients as a result of bacteremia after oral cavity infection. It causes thrombophlebitis in the internal jugular vein. Infection can easily occur during immunosuppressive treatment in patients with systemic lupus erythematosus and become severe. We present a case of Lemierre syndrome in a patient with systemic lupus erythematosus. A 56-year-old woman presented with fever, left lower toothache, and skin symptoms from the left neck to the anterior chest. Clinical presentation and laboratory investigations revealed Lemierre syndrome. The inflammation and thrombus disappeared with antibiotic and anticoagulant therapies. However, transient hypocomplementemia and elevated antinuclear antibody levels were observed during treatment; therefore, a concomitant systemic lupus erythematosus flare was considered. In systemic lupus erythematosus patients with Lemierre syndrome, complement and antinuclear antibody levels are modified, so other indicators should be precisely evaluated, such as levels of urinary protein, sediment, serum creatinine and anti-dsDNA antibody, and systemic lupus erythematosus disease activity index.

show abstract

“…16 Sève et al 17 conducted a computer-assisted search of publications related to systemic lupus erythematosus (SLE) associated with HPVB19 infection dated from 1975 to 2003 and found that 19 out of 38 patients showed self-limited lupus-like symptoms, and none had renal involvement. Saeki et al 18 also reported a case mimicking SLE caused by HPVB19 infection, and their patient had no urinary abnormality. To our knowledge, there are few reports about the relationship between HPVB19 infection and lupus nephritis.…”

Section: Discussionmentioning

confidence: 97%

Human Parvovirus B19-Induced Acute Glomerulonephritis: A Case Report

et al. 2012

View full text Add to dashboard Cite

Human parvovirus B19 (HPV B19) infection is well known as a cause of erythema infectiosum in children. Acute glomerulonephritis due to HPVB19 infection is rarely observed in adults. Here, we present the case of a 45-year-old female who showed acute glomerulonephritis induced by HPVB19 infection with various autoantibodies. She had proteinuria (175 mg/g creatinine) and hematuria (20-29 erythrocytes per high-power field) in a urinalysis, and various autoantibodies such as antinuclear antibodies, proteinase-3-antineutrophil cytoplasmic antibodies (PR3-ANCA), antiglomerular basement membrane (GBM) antibodies, and anticardiolipin antibodies in a blood examination. A renal biopsy showed that endocapillary proliferative glomerulonephritis comprised of mononuclear cell infiltration. By using immunofluorescence microscopy, IgG, IgA, IgM, C3, C4, and C1q deposits were detected mainly in glomerular capillaries. Electron-dense deposits were detected in the subendothelial area and mesangial area by using electron microscopy. All symptoms and abnormal laboratory data were self-improved. Our patient's case may provide a clue to the etiology of ANCA-associated vasculitis or lupus nephritis.

show abstract

Human parvovirus B19 infection mimicking systemic lupus erythematosus

Cited by 12 publications

References 10 publications

Parvoviral infection with systemic impact and renal consequences

Parvoviral infection with systemic impact and renal consequences

A case of Lemierre syndrome combined with a suspected systemic lupus erythematosus flare

Human Parvovirus B19-Induced Acute Glomerulonephritis: A Case Report

Contact Info

Product

Resources

About