Human Parvovirus B19 Infection Induced Severe Aplastic Anemia in an Immunocompetent Adult Without Hematological Disease

Alataby, Harith; Al-Zakhari, Rana; Ahmed, Jibran; Collins, Jennifer J. P.; Moaddab, Amirhossien; Nfonoyim, Jay

doi:10.14740/cii97

Cited by 3 publications

(3 citation statements)

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“…Despite being an adult male, our patient's condition was severe. The course of our patient's illness differed slightly from that of previously described cases in immunocompetent patients [ 8 , 10 , 11 ]. Fever with chills and rigor was present in our patient, as in prior reported cases [ 10 ].…”

Section: Discussioncontrasting

confidence: 61%

“…Rajput et al suggest that parvovirus B19 can have significant marrow aplastic effects even in immunocompetent individuals [ 10 ]. Previously, only three cases of aplastic anemia in immunocompetent adult women had been reported [ 8 , 10 , 11 ]. This is the fourth case reporting severe aplastic anemia in immunocompetent adults and the first case reported in an immunocompetent adult male.…”

Section: Discussionmentioning

confidence: 99%

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Aplastic anemia induced by human parvovirus B19 infection in an immunocompetent adult male without prior hematological disorders: A case report

Bhattarai

Dhakal

Rokaya

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Aplastic anemia induced by human parvovirus B19 infection in an immunocompetent adult male without prior hematological disorders: A case report

Bhattarai

Dhakal

Rokaya

et al. 2022

Annals of Medicine &Amp; Surgery

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“…On the other hand, the current study demonstrated a high association between the presence of maternal anemia and B19V IgM positivity which might be a risk for infection or a consequence of infection which can be found in other studies on maternal B19 infections [19,20] In addition, several studies on B19V-associated anemia whether mild, chronic, or aplastic anemia due to the viral tropism to erythrocytes, the virus could be a risk factor for anemia in pregnant women and fetal anemia also which is the most important risk factor for fetal loss [21,22,23].…”

Section: Discussionmentioning

confidence: 83%

Seroprevalence study of Parvovirus B19 among women with miscarriage in Mosul city

Nawfal Buraa,

Baqer Al-Obaidi,

Ali Hussein

2023

DJM

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Background: Miscarriage and stillbirth are among the most common pregnancy complications, and could be caused by several factors, among these factors are viral infections some of them are obvious teratogenic and others are associated with fetal defects like severe anemia in the case of Parvovirus B19 which could be transmitted vertically causing fetal infection and miscarriage or stillbirth. Objective: To investigate the seroprevalence of Parvovirus B19 among women with miscarriage and stillbirth and compare them with normal pregnant women in the city of Mosul-Iraq. Patients and Methods: A case-control study conducted on pregnant aged 16-45 years with miscarriage and stillbirth admitted to Al-Khansa Teaching Hospital in Mousl city. The samples were collected during the period from November 2022 and January 2023 from 160 from pregnant women, 80 of them had miscarriage or stillbirth, and the other 80 had normal uneventfull pregnancy (control). Serum samples were subjected for ELISA Study of anti-B19V IgG and IgM antibodies. Results: This study showed that the seroprevalence rate of anti-B19V IgG among pregnant women was about 23% (37 out of 160), subdivided into (40%) 32 out of 80 patients, and (6.2%) 5 out of 80 controls had positive anti-B19V IgG antibody which is significantly different. And IgM seroprevalence was about 22% (35 out of 160), in which (38.8%) 31 out of 80 patients, and (5%) 4 out of 80 controls had positive anti-B19V IgM antibody. Both anti-B19V IgG and IgM were higher among patients who had stillbirth than those who had miscarriage both qualitatively and quantitatively. On the other hand, there is a highly significant association of anti-B19V IgM positivity with maternal anemia. Conclusion: The study found high association between B19V and miscarriage or stillbirth as compared to normal pregnancy, and this was more common among patients who had stillbirth than those who had miscarriage, with obvious association with maternal anemia, all of the above is among pregnant women from Mosul City in Iraq. Keywords: miscarriage , stilbirth

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Parvovirus B19 induced acute severe anaemia in a well-controlled HIV-positive individual

Swaine,

Ahmad,

Abbara

et al. 2024

Clinical Infection in Practice

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Human Parvovirus B19 Infection Induced Severe Aplastic Anemia in an Immunocompetent Adult Without Hematological Disease

Cited by 3 publications

References 0 publications

Aplastic anemia induced by human parvovirus B19 infection in an immunocompetent adult male without prior hematological disorders: A case report

Aplastic anemia induced by human parvovirus B19 infection in an immunocompetent adult male without prior hematological disorders: A case report

Seroprevalence study of Parvovirus B19 among women with miscarriage in Mosul city

Parvovirus B19 induced acute severe anaemia in a well-controlled HIV-positive individual

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