Human Parvovirus B19 Infection in Patients with Coronary Atherosclerosis

Liu, Shih-Chi; Tsai, Chia Ti; Wu, Cho‐Kai; Yu, Meng-Fen; Wu, Mu-Zon; Lin, Liang-In; Wang, Shoei‐Shen; Hwang, Juey‐Jen; Tseng, Yung‐Zu; Chiang, Fu-Tien; Tseng, Chuen-Den

doi:10.1016/j.arcmed.2009.09.002

Cited by 18 publications

(18 citation statements)

References 28 publications

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“…Its particular tropism for myocardium and liver, here reported, suggests to further study the possible role of PARV4 infection in heart and liver diseases, considering also that PARV4 infection has been frequently detected in HCV infected patients. It is to note that also B19V is frequently detectable in liver and myocardial tissue both in acute and persistent B19V infection and its importance in liver and heart diseases still remains unclear [17-21]. …”

Section: Discussionmentioning

confidence: 99%

Human parvovirus PARV4 DNA in tissues from adult individuals: a comparison with human parvovirus B19 (B19V)

Corcioli

Zakrzewska

Fanci

et al. 2010

Virol J

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BackgroundPARV4 is a new member of the Parvoviridae family not closely related to any of the known human parvoviruses. Viremia seems to be a hallmark of PARV4 infection and viral DNA persistence has been demonstrated in a few tissues. Till now, PARV4 has not been associated with any disease and its prevalence in human population has not been clearly established. This study was aimed to assess the tissue distribution and the ability to persist of PARV4 in comparison to parvovirus B19 (B19V).ResultsPARV4 and B19V DNA detection was carried out in various tissues of individuals without suspect of acute viral infection, by a real time PCR and a nested PCR, targeting the ORF2 and the ORF1 respectively. Low amount of PARV4 DNA was found frequently (>40%) in heart and liver of adults individuals, less frequently in lungs and kidneys (23,5 and 18% respectively) and was rare in bone marrow, skin and synovium samples (5,5%, 4% and 5%, respectively). By comparison, B19V DNA sequences were present in the same tissues with a higher frequency (significantly higher in myocardium, skin and bone marrow) except than in liver where the frequency was the same of PARV4 DNA and in plasma samples where B19V frequency was significantly lower than that of PARV4ConclusionsThe particular tropism of PARV4 for liver and heart, here emerged, suggests to focus further studies on these tissues as possible target for viral replication and on the possible role of PARV4 infection in liver and heart diseases. Neither bone marrow nor kidney seem to be a common target of viral replication.

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Section: Discussionmentioning

confidence: 99%

Human parvovirus PARV4 DNA in tissues from adult individuals: a comparison with human parvovirus B19 (B19V)

Corcioli

Zakrzewska

Fanci

et al. 2010

Virol J

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“…Of note, a difference in viral DNA load among atherosclerotic patients has been already described in the study by Liu et al . previously mentioned, thus suggesting an heterogeneity in plaque viral DNA load among patients. This issue should be addressed in future studies as well as those regarding the role of active virus replication (mRNA or proteins identification) and the precise localization of virus (coronary plaque vs. endothelial cells in the neighbourhood of the plaque).…”

Section: Discussionmentioning

confidence: 68%

“…Indeed, to exclude a possible contamination from circulating blood cells, we have performed PVB19 DNA PCR analysis in blood samples collected at the time of myocardial revascularization and found a PVB19 DNA prevalence < 1% in blood samples, which is in line with previous data [22], thus further strengthening our findings and excluding possible contamination by circulating blood cells. Thus, PVB19 detected on balloon used for predilatation comes from coronary plaque and presumably from endothelial cells of the intima as shown in a study by Liu et al [14]. Because of its limited genomic capacity, PVB19 requires mitotically active host cells for replication [15], and stent implantation may have well triggered its replication [1].…”

Section: Discussionmentioning

confidence: 96%

Parvovirus B19 at the culprit coronary stenosis predicts outcome after stenting

Niccoli

Severino

Pieroni

et al. 2013

Eur J Clin Investigation

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“…Haidari et al [137] showed that infection of mice with influenza-A exacerbated plaque burden, and they also showed that influenza specific T cells likely play a role. Moreover, Boddi et al [138] showed that Hepatitis C virus, and Liu et al [139] showed that human Parvovirus B19 are present human carotid plaques, which suggests that T cells specific for these pathogens may contribute to plaque inflammation, and the onset of acute coronary syndromes.…”

Section: Low Serum Fetuin-a Concentration Predicts Poor Outcome Only mentioning

confidence: 97%