Human parvovirus B19 and low hemoglobin levels in pregnant Sudanese women

Gasim, Gasim I.; Eltayeb, Reem; Elhassan, Elhassan M.; Haggaz, AbdElrahium D.; Rayis, Duria A.

doi:10.1016/j.ijgo.2015.07.027

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…As for IgM, the prevalence of 1.3% (or 2.6% if one also considers indeterminate samples at immunoblot) is similar to that found in some African studies [23, 34, 37] but lower than in other works where prevalences of 13%–41.8% were reported [31, 32, 35, 39]. These differences may depend on the epidemic or non‐epidemic period in which the various studies were conducted.…”

Section: Discussionsupporting

confidence: 82%

“…We saw no significant variations in IgG prevalence with age. Although an increase in prevalence with age is described in the literature [7], it is also reported that in African pregnant women, there is no such difference as they have already encountered the infection before reaching the age of conception [23, 25, 34]. We also found no difference between trimesters of pregnancy (there are conflicting data in the literature [32, 34, 35]), nor in relation to cases of abortion [34, 41].…”

Section: Discussionsupporting

confidence: 41%

“…Although an increase in prevalence with age is described in the literature [7], it is also reported that in African pregnant women, there is no such difference as they have already encountered the infection before reaching the age of conception [23,25,34]. We also found no difference between trimesters of pregnancy (there are conflicting data in the literature [32,34,35]), nor in relation to cases of abortion [34,41]. Instead, we found a significant difference in relation to occupation, with a higher prevalence among housewives than other occupations, as previously reported [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

Paschale

Ceriani

Cerulli³

et al. 2023

Tropical Med Int Health

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Objectives: Parvovirus B19 (B19V) infection in pregnancy is generally asymptomatic, but in about 3% it can cause complications, including miscarriage, severe foetal anaemia and foetal hydrops. The seroprevalence in pregnancy ranges from 20% to 82% in Africa, but there are no data for Benin. We therefore retrospectively assessed the seroprevalence of B19V in pregnant women attending the Saint Jean de Dieu Hospital in Tanguiéta, a rural district of Atacora, in northern Benin. Methods: We searched for anti-B19V immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies in 227 sequential sera from as many women (mean age 26.3 years, range: 16-41) of whom 30 were in the first trimester, 66 in the second and 131 in the third. Samples that tested positive for IgM were analysed with an immunoblot test and the viral genome (DNA-B19V) was searched for using a polymerase chain reaction. Results: Of the 227 women, 153 (67.4%) were positive for IgG anti-B19V, 7 (3.1%) for IgM and 73 (32.2%) were non-immune. Six IgM-positive women were also IgG positive. The difference in IgG seroprevalence between trimesters or ages was not statistically significant. Of the seven IgM-positive samples, three were confirmed positive by immunoblot (of which two were DNA-B19V positive), three were indeterminate (DNA-B19V negative) and one was negative (DNA-B19V negative). Of the three women with confirmed positive IgM, two were in the third trimester and one in the second trimester of pregnancy. Conclusions: The seroprevalence of anti-B19V IgG among pregnant women in Benin is high and in line with those reported in some African countries. IgM seroprevalence is also similar to that described in some African countries in non-epidemic periods. The low viral load observed depicts non-acute infections, but it is difficult to establish the precise time of the infection, especially for women tested in the second or third trimester of pregnancy, when the observed viremia could be a sign of an acute infection that occurred in the previous trimester. Consequently, clinical follow-up and further investigations to highlight possible foetal consequences are indicated.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 99%

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Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

Paschale

Ceriani

Cerulli³

et al. 2023

Tropical Med Int Health

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“…Acute B19V infection may occur concurrently with malaria (752,753). Among pregnant Sudanese women, seropositivity for IgG to B19V was associated with lower hemoglobin levels (754).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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“…It is known that B19V causes acute anemia in immunocompromised individuals and pure red blood cell aplasia, which are conditions characterized by an abnormal formation of red blood cells [ 5 , 53 ]. Furthermore, it is dated that B19V infection is associated with a significant decrease in Hgb level among adults and children [ 54 , 55 , 56 ]. However, in this study, there are no differences observed in the Hgb level and other parameters of blood and the CSF tests such as WBC and RBC count, pleocytosis, glucose level etc., between the patients with active parvovirus infection and the patients with active infection caused by other infectious agents, showing that parvovirus infection does not cause specific changes in blood and CSF composition among the patients with meningitis or meningoencephalitis.…”

Section: Discussionmentioning

confidence: 99%

Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis

et al. 2020

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Meningitis and meningoencephalitis are neurological inflammatory diseases, and although routine diagnostics include testing of a wide range of pathogens, still in many cases, no causative agent is detected. Human parvovirus B19 (B19V), human bocaviruses 1–4 (HBoV1–4), and human parvovirus 4 (hPARV4) are members of the Parvoviridae family and are associated with a wide range of clinical manifestations including neurological disorders. The main aim of this study was to determine whether human parvoviruses infection markers are present among patients with meningitis/meningoencephalitis in Latvia as well as to clarify the role of these viruses on the clinical course of the mentioned diseases. Our study revealed HBoV1–4 and B19V genomic sequences in 52.38% and 16.67% of patients, respectively. Furthermore, symptoms such as the presence of a headache and its severity, fatigue, disorientation, and difficulties to concentrate were significantly frequently present in patients with active parvovirus infection in comparison with parvoviruses negative patients, therefore we suggest that HBoV1–4 and B19V infection should be included in the diagnostics to reduce the number of meningitis/meningoencephalitis with unknown/unexplained etiology.

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Human parvovirus B19 and low hemoglobin levels in pregnant Sudanese women

Abstract: B19V IgG seropositivity was 49.7% among the study group. These patients exhibited lower hemoglobin levels and a significant association was found between B19V IgG seropositivity and hemoglobin level.

Cited by 5 publications

References 17 publications

Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

Human Parvoviruses

Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis

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