Human parechovirus meningitis and gross-motor neurodevelopment in young children

Hinsbergh, Ted M. T. van; Crom, Stephanie C. M. de; Lindeboom, Robert; Furth, A. Marceline van; Obihara, Charlie C.

doi:10.1007/s00431-019-03319-6

Cited by 8 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the most severe cases of PVM, fatal conditions of unconsciousness, seizure, and shock were also observed (167). In a recent study, it was shown that the PVM due to HPeV can adversely affect the neurodevelopment in young children resulting in grossmotor functional delay (168). In a long-term retrospective hospital-based study, pathological complications of PVM due to herpes viral infections in neonates and infants were determined.…”

Section: Complications and Consequencesmentioning

confidence: 99%

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

et al. 2022

View full text Add to dashboard Cite

Meningitis is an inflammation of the brain and spinal cord meninges caused by infectious and non-infectious agents. Infectious agents causing meningitis include viruses, bacteria, and fungi. Viral meningitis (VM), also termed aseptic meningitis, is caused by some viruses, such as enteroviruses (EVs), herpesviruses, influenza viruses, and arboviruses. However, EVs represent the primary cause of VM. The clinical symptoms of this neurological disorder may rapidly be observed after the onset of the disease, or take prolonged time to develop. The primary clinical manifestations of VM include common flu-like symptoms of headache, photophobia, fever, nuchal rigidity, myalgia, and fatigue. The severity of these symptoms depends on the patient's age; they are more severe among infants and children. The course of infection of VM varies between asymptomatic, mild, critically ill, and fatal disease. Morbidities and mortalities of VM are dependent on the early recognition and treatment of the disease. There were no significant distinctions in the clinical phenotypes and symptoms between VM and meningitis due to other causative agents. To date, the pathophysiological mechanisms of VM are unclear. In this scientific communication, a descriptive review was performed to give an overview of pediatric viral meningitis (PVM). PVM may occasionally result in severe neurological consequences such as mental retardation and death. Clinical examinations, including Kernig's, Brudzinski's, and nuchal rigidity signs, were attempted to determine the clinical course of PVM with various success rates revealed. Some epidemiological correlates of PVM were adequately reviewed and presented in this report. They were seen depending mainly on the causative virus. The abnormal cytological and biochemical features of PVM were also discussed and showed potentials to distinguish PVM from pediatric bacterial meningitis (PBM). The pathological, developmental, behavioral, and neuropsychological complications of PVM were also presented. All the previously utilized techniques for the etiological diagnosis of PVM which include virology, serology, biochemistry, and radiology, were presented and discussed to determine their efficiencies and limitations. Finally, molecular testing, mainly PCR, was introduced and showed 100% sensitivity rates.

show abstract

Section: Complications and Consequencesmentioning

confidence: 99%

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Most studies reported a higher incidence in males (56.4–91%) than in females [ 9 – 11 , 17 , 21 , 27 , 59 , 60 , 62 , 65 , 66 ]. Only two Korean studies reported a female prevalence (57.1-80%) [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fever was the most frequent presenting sign [ 1 , 41 , 44 – 47 , 49 , 50 , 52 – 58 ]. In fact, fever occurrence ranged between 80% and 100% [ 8 , 10 – 12 , 14 , 17 , 21 , 23 , 25 – 28 , 32 , 33 , 60 – 64 , 69 , 70 ]. However, in an American retrospective study, 2% of patients reported hypothermia (TC < 35 °C) instead of hyperthermia [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Human parechovirus meningitis in children: state of the art

Bozzola,

Barni,

Barone

et al. 2023

Ital J Pediatr

View full text Add to dashboard Cite

Human Parechovirus is a common cause of infection occurring especially during the first years of life. It may present with a broad spectrum of manifestations, ranging from a pauci-symptomatic infection to a sepsis-like or central nervous system disease. Aim of this study is to explore the knowledge on Parechovirus meningitis. According to the purpose of the study, a systematic review of the literature focusing on reports on central nervous system. Parechovirus infection of children was performed following PRISMA criteria. Out of the search, 304 papers were identified and 81 records were included in the revision dealing with epidemiology, clinical manifestations, laboratory findings, imaging, therapy and outcome. Parechovirus meningitis incidence may vary all over the world and outbreaks may occur. Fever is the most common symptom, followed by other non-specific signs and symptoms including irritability, poor feeding, skin rash or seizures. Although several reports describe favourable short-term neurodevelopmental outcomes at discharge after Parechovirus central nervous system infection, a specific follow up and the awareness on the risk of sequelae should be underlined in relation to the reported negative outcome. Evidence seems to suggest a correlation between magnetic imaging resonance alteration and a poor outcome.

show abstract

“…15 HPeVs and EVs are considered leading cause of aseptic meningitis and encephalitis, 3 and because of their pathogenic potential, increasing frequency of detection (even in healthy individuals) and ability to cause severe infections, HPeVs attracts more attention and considered of global relevance. 2,3,10,11,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] pathology seen. [33][34][35] The fact that Tall-like receptor 7 and 8 play important innate immune response against PeV-A1 and possibly PeV-A3 further support severe CNS presentation of PeV-A1 and 3 infection, more especially in children due to inhibition of axonal growth and induction of neuronal apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…They cause a wide spectrum of both localized and systemic infections that affect many organ systems 15 . HPeVs and EVs are considered leading cause of aseptic meningitis and encephalitis, 3 and because of their pathogenic potential, increasing frequency of detection (even in healthy individuals) and ability to cause severe infections, HPeVs attracts more attention and considered of global relevance 2,3,10,11,16‐32 . However, despite global effort to develop comprehensive data on HPeVs, much of what is known is from pediatric infections, which create a gap in the epidemiology of HPeV infection.…”

Section: Introductionmentioning

confidence: 99%

Human parechovirus are emerging pathogens with broad spectrum of clinical syndromes in adults

Kabuga

Nejati

Soheili

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

Parechoviruses are emerging pathogens of humans often affecting the pediatric age group, with a growing line of evidence implicating them as agents of a broad spectrum of clinical syndromes in adults. However, because many clinicians are not familiar with the manifestation of the infections, they are not included in the list of diagnostic pathogens. Furthermore, due to the indistinguishable feature of the infection compared with other common pathogens, a large number of cases are likely to go unchecked. Some may develop asymptomatic infection and recover without overt clinical disease. In this manuscript, we reviewed available literature on parechovirus infection in adult and summarized information relating to epidemiology, clinical manifestation, laboratory diagnosis, and therapeutics. The information provided should help in early case detection and support an evidence‐based clinical decision.

show abstract

Human parechovirus meningitis and gross-motor neurodevelopment in young children

Cited by 8 publications

References 29 publications

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

Human parechovirus meningitis in children: state of the art

Human parechovirus are emerging pathogens with broad spectrum of clinical syndromes in adults

Contact Info

Product

Resources

About