Human Parechovirus Infection in Children Hospitalized with Acute Gastroenteritis in Sri Lanka

Pham, Ngan Thi Kim; Takanashi, Sayaka; Tran, Dinh Nguyen; Trinh, Quang Duy; Abeysekera, Chandra; Abeygunawardene, Asiri; Khamrin, Pattara; Okitsu, Shoko; Shimizu, Hiroyuki; Mizuguchi, Masashi; Ushijima, Hiroshi

doi:10.1128/jcm.02151-10

Cited by 47 publications

(46 citation statements)

References 22 publications

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“…However, the results here cannot be compared to those of other studies [Abed and Boivin, 2006;Watanabe et al, 2007;Baumgarte et al, 2008;Benschop et al, 2008;van der Sanden et al, 2008;Drexler et al, 2009;Ito et al, 2010;Pham et al, 2010aPham et al, , 2011a because these other studies were potentially biased from: (1) being based primarily on culture isolates, which can be biased because of the inability of the virus variants to replicate in certain cell lines; (2) being based one-step PCR directly screened from stool samples; or (3) the samples excluded the other gastroenteritis-associated viruses, such as rotavirus, human calicivirus, astrovirus, adenovirus, norovirus, and human bocavirus. The inconsistencies are unlikely to be caused by crosscontaminations with strict control measures in nucleic acid extraction and PCR analysis.…”

Section: Discussioncontrasting

confidence: 61%

“…HPeV4 through 8, 10, 11, and 14 were discovered, respectively, in the Netherlands, the United States, Japan, Pakistan, Brazil, Sri Lanka, and Thailand [Oberste et al, 1998;Benschop et al, 2006bBenschop et al, , 2008Watanabe et al, 2007;Drexler et al, 2009;Li et al, 2009;Calvert et al, 2010;Pham et al, 2010bPham et al, , 2011a. Finally, there are unpublished reports of types 9, 12, and 13 (http://www.picornastudygroup.com/types/ parechovirus/hpev.htm) based on VP1 sequence comparisons ], but clinical data on these types are lacking.…”

Section: Introductionmentioning

confidence: 97%

“…HPeV1 is a widely dispersed pathogen that mainly affects young children [Joki-Korpela and Hyypiä , 2001; Legay et al, 2002;Abed and Boivin, 2006;Zhang et al, 2009;Benschop et al, 2010;Ito et al, 2010;Pham et al, 2010aPham et al, , 2011a. HPeV2 infections are rare and are mostly associated with gastrointestinal symptoms [Ehrnst and Eriksson, 1996].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and genotypes of human parechovirus in stool samples from hospitalized children in Shanghai, China, 2008 and 2009

Zhong

Yan

Sun

et al. 2011

Journal of Medical Virology

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Human parechoviruses (HPeVs) are widespread pathogens belonging to the Picornavirus family. The aim of the present study was to assess the prevalence and genetic diversity of HPeV in Shanghai, China, during a HPeV screening program in 2008 and 2009. Of 300 stool samples from children under the age of 5 years with acute diarrhea seen at Children's Hospital, Fudan University, Shanghai, China, 165 (55%) were HPeV-positive. The median age of infected children was 3 months. The prevalence of HPeV was high (57%) in infants up to 2 years old but dropped to 30.4% in children between 2 and 5 years old. The prevalence did not differ by sex. Infections were present throughout the year but peaked in July and August. The most predominant genotype was HPeV1. Of the 139 strains, 4 were found in 9 samples: HPeV4 (n = 4), HPeV5 (n = 1), HPeV6 (n = 1), and HPeV8 (n= 3). This study provided useful data on the epidemiology of HPeV infection by documenting the distribution of genotypes, age of infection, and seasonal patterns in Shanghai, China.

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Section: Discussioncontrasting

confidence: 61%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Prevalence and genotypes of human parechovirus in stool samples from hospitalized children in Shanghai, China, 2008 and 2009

Zhong

Yan

Sun

et al. 2011

Journal of Medical Virology

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“…A third HPeV (HPeV-3) was reported in 2004, and since then, up to 17 genotypes of HPeV have been identified and classified based on VP1 sequences (Ito et al, 2004;Benschop et al, 2006;Al-Sunaidi et al, 2007;Watanabe et al, 2007;Benschop et al, 2008;Kim Pham et al, 2010;Pham et al, 2011;Nix et al, 2013;Chuchaona et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Human parechovirus infections and child myositis cases associated with genotype 3 in Osaka City, Japan, 2014

Yamamoto

Kaida

Naito

et al. 2015

Journal of Medical Microbiology

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Human parechovirus (HPeV) infects humans early in life and typically causes asymptomatic or mild diseases such as gastrointestinal and respiratory illness but sometimes leads to more serious consequences in neonates and young infants. In 2014, we detected HPeV from 38 patients by real-time reverse transcription-PCR in Osaka City, Japan, and 33 HPeV strains were genotyped based on their VP1 sequences. HPeV genotype 3 (HPeV-3) was the most prevalent and accounted for 22 cases (66.7 %) followed by nine HPeV-1 (27.3 %), one HPeV-2 (3.0 %) and one HPeV-4 (3.0 %). Phylogenetic analysis revealed that detected HPeV-3 strains were divided into three genetically distinct groups. One was characterized by a novel single amino acid deletion mutation at the N terminus of the 2A protein as well as the VP1 sequence, whereas the others were closely related to HPeV-3 strains detected in Japan in either 2008 or 2011. These HPeV-3 groups were detected from patients with various symptoms including three myositis cases. Recent papers have demonstrated that HPeV-3 was the aetiological agent for epidemic myalgia exclusively among adults from Yamagata Prefecture in Japan. Here, we provide clinical details and episodes of three myositis patients including an adult and two children in Osaka City, Japan. Our results suggest that HPeV-3 is a causative agent of myositis not only in adults but also in children.

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“…Several studies where age was taken into account describe HPeV infection to be mostly restricted to children under 2 years of age (28)(29)(30)(31). Other studies more specifically indicate that HPeV infections were found in young infants (Ͻ3 months), whereas older children and adults were not infected (27,30).…”

Section: Discussionmentioning

confidence: 99%

Environmental Surveillance of Human Parechoviruses in Sewage in the Netherlands

Lodder

Wuite

Husman

et al. 2013

Appl Environ Microbiol

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The circulation of human parechoviruses (HPeVs) in the population was studied by environmental surveillance comprising of molecular analyses of sewage samples (n ‫؍‬ 89) that were collected from 15 different locations in the Netherlands. Samples were taken from sewage originating from schools (n ‫؍‬ 9) or from parts of municipalities (n ‫؍‬ 6) during the Dutch school year 2010-2011. At 13/15 locations HPeV1, HPeV3, or HPeV6 RNA was detected at least once; however, sequence diversity did not reflect associations in time or place. A higher percentage of positives was observed in the samples originating from the municipalities. It was demonstrated that HPeV circulated in the studied population to a higher extent than would be expected from the current knowledge on infections predominating in young children.

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Human Parechovirus Infection in Children Hospitalized with Acute Gastroenteritis in Sri Lanka

Cited by 47 publications

References 22 publications

Prevalence and genotypes of human parechovirus in stool samples from hospitalized children in Shanghai, China, 2008 and 2009

Prevalence and genotypes of human parechovirus in stool samples from hospitalized children in Shanghai, China, 2008 and 2009

Human parechovirus infections and child myositis cases associated with genotype 3 in Osaka City, Japan, 2014

Environmental Surveillance of Human Parechoviruses in Sewage in the Netherlands

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