Human papillomaviruses-related cancers

Moustafa, Ala‐Eddin Al; Al‐Awadhi, Rana; Missaoui, Nabiha; Adam, Ishag; Durusoy, Raika; Ghabreau, Lina; Akil, Nizar; Ahmed, Hussain Gadelkarim; Yasmeen, Amber

doi:10.4161/hv.28742

Cited by 36 publications

(27 citation statements)

References 128 publications

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“…In order to further explore the prevalence of EBV and high-risk HPVs in human HN cancers including oral malignancy in the Syrian population, we examined the presence of these viruses in a cohort of 80 oral cancer tissue samples from Syria using immunohistochemistry and Tissue Microarray methodologies. Our data revealed that 43% of these cancers are positives for high-risk HPVs ( 48 , 49 , 83 ). Genotyping investigation of high-risk HPVs showed that HPV types 16, 18, 31, 33, and 35 are the most frequent HPV types in HN cancers in Syria ( 94 ).…”

Section: Ebv/hpvs Interaction and Emt In Human Cancermentioning

confidence: 65%

Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression

et al. 2018

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Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein–Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, it is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or progression of several human carcinomas, including cervical, oral, and breast. More significantly, it has been recently pointed out that viral onco-proteins of EBV and high-risk HPVs can be co-present and consequently cooperate to initiate and/or amplify epithelial–mesenchymal transition (EMT), which is the hallmark of cancer progression and metastasis. This could occur by β-catenin, JAK/STAT/SRC, PI3k/Akt/mTOR, and/or RAS/MEK/ERK signaling pathways, which onco-proteins of EBV and HPVs share. This review presents the most recent advances related to EBV and high-risk HPVs onco-proteins interactions and their roles in the progression of human carcinomas especially oral and breast via the initiation of EMT.

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Section: Ebv/hpvs Interaction and Emt In Human Cancermentioning

confidence: 65%

Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression

et al. 2018

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“…[1][2] In parallel, the role of E5, E6/E7 of high-risk Well, High-risk HPVs are considered among the major viruses associated with several human cancers especially cervical as well as head and neck (HN), colorectal and breast cancer; as roughly 96, 30, 80 and 50% of these cancers were revealed positive for these viruses, respectively. 4 Moreover, it was observed that the presence of high-risk HPVs serve as a prognostic factor in early-stage cervical, HN, and colorectal cancers, and are associated with vascular invasion, lymph node metastases and tumor size. 5 In parallel, it has been shown that high-risk HPVs are present in human breast cancer and their presence is associated with more aggressive phenotype; 4,5 accordingly, we have recently demonstrated that E6/E7 of high-risk HPV type 16, which is the most frequent type of the high-risk group worldwide, converts non-invasive and non-metastatic breast cancer cells to invasive and metastatic form; this occurs via the activation of the Id-1 full promoter by E6/E7 onco-proteins.…”

Section: Please Scroll Down For Articlementioning

confidence: 98%

E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation

Moustafa¹

2015

Cell Adhesion & Migration

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It is estimated that 10-20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial-mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression.

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“…[ 7 ] It is also implicated with the majority of cases of cervical cancer among sexually active adolescents and young women. [ 8 ] Globally, 75% of individuals will experience an HPV infection at least once in their lifetime. The two most frequent high-risk HPVs (types 16 and 18) were reported worldwide, including the Middle East as well as North African countries which are the most important in the pathogenesis of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

“…The two most frequent high-risk HPVs (types 16 and 18) were reported worldwide, including the Middle East as well as North African countries which are the most important in the pathogenesis of cervical cancer. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of Nursing Intervention on Mothers' Knowledge of Cervical Cancer and Acceptance of Human Papillomavirus Vaccination for their Adolescent Daughters in Abuja – Nigeria

Odunyemi

Ndikom

Oluwatosin

2018

Asia-Pacific Journal of Oncology Nursing

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Objective:The aim of this study is to evaluate the effect of nursing intervention on mothers’ knowledge of cervical cancer and acceptance of human papillomavirus (HPV) vaccination for their adolescent daughters in Abuja, Nigeria.Methods:This was a quasi-experimental study that utilized two groups pre and post-test design. The study was carried out among civil servant mothers in Bwari (experimental group [EG]) and Kwali (control group[CG]) Area Councils of Abuja, Nigeria. One hundred and forty-six women who met the inclusion criteria were purposively selected for this study. EG consists of 69 women while 77 are from CG. The intervention consisted of two days workshop on cervical cancer and HPV vaccination. Descriptive and inferential analyses of the data were performed using SPSS software 20 version.Results:The mean age of the respondents was 35 years ± 6.6 in the EG and 41 years ± 8.2 in the CG. The mean knowledge score of cervical cancer was low at baseline in both EG (9.58 ± 7.1) and CG (11.61 ± 6.5). However, there was a significant increase to 21.45 ± 6.2 after the intervention in EG (P < 0.0001). The baseline acceptance of HPV vaccination was high in EG after intervention from 74% to 99%. Exposure to nursing intervention and acceptance of HPV vaccination was statistically significant after intervention (P < 0.0001).Conclusions:The nursing intervention has been found to increase mothers’ knowledge of cervical cancer and acceptance of HPV vaccination. It is therefore recommended that nurses should use every available opportunity in mothers’ clinic to educate on cervical cancer and HPV vaccination.

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Human papillomaviruses-related cancers

Cited by 36 publications

References 128 publications

Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression

Epstein–Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial–Mesenchymal Transition and Cancer Progression

E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation

Effect of Nursing Intervention on Mothers' Knowledge of Cervical Cancer and Acceptance of Human Papillomavirus Vaccination for their Adolescent Daughters in Abuja – Nigeria

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