Human Papillomaviruses and Cervical Cancer

DiMaio, Daniel; Liao, John B.

doi:10.1016/s0065-3527(06)66003-x

Cited by 48 publications

(43 citation statements)

References 273 publications

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“…More than 40 genotypes that are capable of infecting genital mucous membranes have been identified and characterized (38,46,142,157,211). These HPV genotypes are usually divided into two groups according to their oncogenic potentials (236).…”

Section: Pathogenicitymentioning

confidence: 99%

“…Interestingly, the integration of HPV DNA into the host genome interrupts the E1 or E2 ORF, while the E6 and E7 ORFs remain intact. Since the E2 protein represses the expression of the E6 and E7 genes (38,207,235), the loss of the E2 ORF upon the integration of viral DNA promotes the synthesis of the E6 and E7 proteins, most probably contributing in this way to cancer development (9,190,230). In this context, HPV genome integration represents a rather rare and paradoxical phenomenon of viral replication (235).…”

Section: Molecular Mechanisms Of Carcinogenesis Induced Bymentioning

confidence: 99%

“…Although it has been reported that HPV E5 displays some (rather weak) transforming potential, the exact molecular basis of its action is not fully elucidated (199,201), and our current knowledge concerning this subject will be presented in the following sections. Oncogenic genital HPVs differ from low-risk HPVs mainly by the biological properties of the E6 and E7 proteins (38,45), which, working synergistically, play a central role in the process of malignant transformation. It is believed that their persistent expression is necessary for the maintenance of a transformed phenotype (39,141).…”

Section: Molecular Mechanisms Of Carcinogenesis Induced Bymentioning

confidence: 99%

“…HPVs are a heterogeneous group of widespread DNA viruses, and they differ largely in their tropisms and oncogenic potentials (38,189,236). HPVs are the agents of skin lesions (different clinical types of warts) or mucous membrane lesions (genital warts or condylomas and cervical, anal, vulvar, or vaginal intraepithelial neoplasias), which in general are spontaneously cured but can evolve toward invasive cancer under certain conditions.…”

Section: Introductionmentioning

confidence: 99%

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The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Łazarczyk

Cassonnet

Pons

et al. 2009

Microbiol Mol Biol Rev

133

128

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SUMMARY Infections by human papillomaviruses (HPVs) are the most frequently occurring sexually transmitted diseases. The crucial role of genital oncogenic HPV in cervical carcinoma development is now well established. In contrast, the role of cutaneous HPV in skin cancer development remains a matter of debate. Cutaneous beta-HPV strains show an amazing ubiquity. The fact that a few oncogenic genotypes cause cancers in patients suffering from epidermodysplasia verruciformis is in sharp contrast to the unapparent course of infection in the general population. Our recent investigations revealed that a natural barrier exists in humans, which protects them against infection with these papillomaviruses. A central role in the function of this HPV-specific barrier is played by a complex of the zinc-transporting proteins EVER1, EVER2, and ZnT-1, which maintain cellular zinc homeostasis. Apparently, the deregulation of the cellular zinc balance emerges as an important step in the life cycles not only of cutaneous but also of genital HPVs, although the latter viruses have developed a mechanism by which they can break the barrier and impose a zinc imbalance. Herein, we present a previously unpublished list of the cellular partners of EVER proteins, which points to future directions concerning investigations of the mechanisms of action of the EVER/ZnT-1 complex. We also present a general overview of the pathogenesis of HPV infections, taking into account the latest discoveries regarding the role of cellular zinc homeostasis in the HPV life cycle. We propose a potential model for the mechanism of function of the anti-HPV barrier.

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Section: Pathogenicitymentioning

confidence: 99%

Section: Molecular Mechanisms Of Carcinogenesis Induced Bymentioning

confidence: 99%

Section: Molecular Mechanisms Of Carcinogenesis Induced Bymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Łazarczyk

Cassonnet

Pons

et al. 2009

Microbiol Mol Biol Rev

133

128

View full text Add to dashboard Cite

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“…HPV replication occurs exclusively in squamous stratified epithelium (such as the epidermis and mucous membranes) [26] which is depend on the cellular differentiation state and abundance of important proteins like transcriptional factors, polymerases, splicing factors, RNA processing machinery etc. [27]. In another study, it was also shown that cervical cancer is one of the major causes of death in women with about 454,000 new cases and 200,000 deaths in 2010 worldwide [28] [29].…”

Section: Introductionmentioning

confidence: 97%

Awareness about Early Detection Methods, Symptoms and Risk Factors towards Breast and Cervical Cancer among the Female Students of Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail, Bangladesh

Zohora¹,

Paul²,

Mahmud³

et al. 2017

ABCR

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The study was conducted to ensure knowledge, attitude, awareness about breast and cervical cancer among the female students of Mawlana Bhashani Science and Technology University. This study was carried out from July to September, 2015 among the participants of university female halls, different female hostels and different faculty of the university by using a validated questionnaire which was developed for this study. A total 250 female students, at the age of (18 -26) years were participated. Collected information was analyzed using SPSS, Graph-pad Prism and MS Excel. The results showed that about 87.6% participants were undergraduate. Most of them come from village (45.6%) and city (36.0%). About 90% were Muslims and the socioeconomic level of most of the participants was middle (90.4%). In case of food intake patterns, it was observed that 35.6% participants eat chips, soft drinks, popcorn everyday; 40.4% eat meat regularly; 24% eat sugar everyday; 27.6% eat fruits and vegetables every day. Among them, 55.6% girls maintained daily 1 hour physical activity; 37.2% did exercise rarely; 34.8% participants rarely do strenuous exercise. About 84.4% respondents have not any family history of cancer; 6% participants have sister or mother having breast tumor and 7.2% have at least more than one close relative who have cancer. Among the participants, only 0.8% drank alcohol; 1.2% have addiction of smoking cigarette; 15.6% girls wear tight bra; 3.6% have benign breast disease and 2.8% participants have attended in breast or cervical cancer screening programs. The 50moderate numbers of girls have breast cancer screening practice. Among them, only 28.8% participants have ever heard about BSE (Breast self-examination) and 40.4% have not any knowledge about breast cancer treatment. About 50.8% respondents don't have any knowledge about cervical cancer treatment. The village people are the most risky group. About 17.02% girls recognized weakened immune system as a risk factor of cervical cancer. It can be concluded that, knowledge of participants regarding breast and cervical cancer is poor. Targeted education should be implemented to improve the knowledge of respondents about early detection methods and symptoms of breast and cervical cancer.

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Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

et al. 2021

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Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18 E6) to degrade its target PSD95/Dlg/ZO-1 (PDZ) proteins. In this study, we demonstrated that the PDZ protein membrane-associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) inhibited the Wnt/b-catenin pathway, and subsequently cervical cancer (CC) cell migration and invasion, via decreasing b-catenin levels. By reducing MAGI3 protein levels, HPV18 E6 promoted CC cell migration and invasion through activation of Wnt/bcatenin signaling. Furthermore, HPV18 rather than HPV16 was preferentially associated with the downregulation of MAGI3 and activation of the Wnt/b-catenin pathway in CC. These findings shed light on the mechanism that gives HPV18 its high carcinogenic potential in CC progression.Cervical cancer (CC) is the fourth most prominent type of cancer in women [1]. Infection with high-risk types of human papillomaviruses (HR-HPVs) is the main cause for the transformation of normal cervical epithelium to cervical intraepithelial neoplasia (CIN) and progression to invasive cervical cancer (ICC) [2,3]. The 5-year overall survival for early-stage patients (stage I) of CC reaches 88%, and this percentage Abbreviations CC, cervical cancer; CIN, cervical intraepithelial neoplasia; CIS, carcinoma in situ; FDR, false discovery rate; GSEA, gene set enrichment analysis; HG-CIN, high-grade cervical intraepithelial neoplasia; HPV16, human papillomavirus type 16; HPV18, human papillomavirus type 18; HR-HPVs, high-risk types of human papillomaviruses; ICC, invasive cervical cancer; IHC, immunohistochemistry; MAGI3, membraneassociated guanylate kinase, WW and PDZ domain containing 3; NHERF1, Na + /H + exchanger regulatory factor 1; PBM, PDZ-binding motif; PDZ, PSD95/Dlg/ZO-1; TCGA, The Cancer Genome Atlas.

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Human Papillomaviruses and Cervical Cancer

Cited by 48 publications

References 273 publications

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Awareness about Early Detection Methods, Symptoms and Risk Factors towards Breast and Cervical Cancer among the Female Students of Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail, Bangladesh

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

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