Human Papillomavirus Vaccine Hesitancy in the United States

Morales-Campos, Daisy; Zimet, Gregory D.; Kahn, Jessica A.

doi:10.1016/j.pcl.2022.11.002

Cited by 7 publications

(5 citation statements)

References 50 publications

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“…This information is also important to oral healthcare and public health professionals, as recent evidence has demonstrated that vaccine hesitancy (particularly related to HPV among pediatric patients) has been increasing in recent years despite strong evidence for the efficacy and safety of both the quadrivalent and nine-valent HPV vaccines [ 38 , 39 , 40 ]. In fact, other recent evidence has also documented the increase in vaccine hesitancy and skepticism about vaccine safety and efficacy over recent years among children, adolescents, and their parents [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the paucity of information regarding HPV52 and HPV58 prevalence among any patient population, this study provides significant evidence that these high-risk strains are present among both pediatric and adult populations [ 32 , 33 ]. In addition, these data also demonstrated that the majority of samples with HPV were derived from patients within the recommended HPV vaccination range, providing significant information for health professionals and public health advocates on the urgent need to disseminate current knowledge about the benefits of the nine-valent HPV vaccine and the potential risks of avoidance for this low-cost and effective prevention method [ 36 , 37 , 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Screening for High-Risk Human Papillomavirus Reveals HPV52 and HPV58 among Pediatric and Adult Patient Saliva Samples

Hinton,

Herrera,

Valenzuela

et al. 2024

Dentistry Journal

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Previous research has demonstrated that the human papillomavirus (HPV) can infect a wide range of human tissues, including those within the oral cavity. High-risk oral HPV strains have been associated with the development and progression of oral cancers, including oral squamous cell carcinomas. Although many studies have examined the prevalence of the high-risk strains HPV16 and HPV18, far fewer have assessed the prevalence of other high-risk HPV strains. An approved study protocol was used to identify HPV52 and HPV58 among clinical samples (n = 87) from a saliva biorepository. Quantitative polymerase chain reaction (qPCR) and validated primers for HPV52 and HPV58 were used to facilitate this screening. This screening demonstrated that a total of n = 4/45 or 8.9% of adult saliva samples harbored high-risk HPV52, and n = 2/45 or 4.4% tested positive for high-risk HPV58. In addition, a total of n = 6/42 or 14.3% of the pediatric saliva samples tested positive for high-risk HPV, including n = 5/42 or 11.9% with HPV52 and n = 3/42 or 7.1% for HPV58. These data demonstrate the presence of the high-risk oncogenic HPV52 and HPV58 strains among both adult and pediatric clinical patient samples. More detailed longitudinal research must be conducted to determine whether this prevalence may be increasing or decreasing over time. In addition, these data strongly support public health prevention efforts, such as knowledge and awareness of the nine-valent HPV vaccine covering additional high-risk strains, including HPV52 and HPV58.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Screening for High-Risk Human Papillomavirus Reveals HPV52 and HPV58 among Pediatric and Adult Patient Saliva Samples

Hinton,

Herrera,

Valenzuela

et al. 2024

Dentistry Journal

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“…Furthermore, previous qualitative and quantitative research has demonstrated the importance of a provider’s role in addressing parental hesitancy of HPV vaccines. It may be that the frequency and quality of provider recommendations, rather than the availability of providers (e.g., healthcare provider shortages), have a stronger or more direct influence on addressing vaccine hesitancy among parents [ 33 , 34 ]. These results emphasize the urgent need to address both area-level factors, such as persistent child poverty and healthcare provider shortages, and individual-level factors (e.g., provider recommendation) in order to increase HPV vaccination rates and coverage among adolescent females.…”

Section: Discussionmentioning

confidence: 99%

Associations of geographic-based socioeconomic factors and HPV vaccination among male and female children in five US states

Xiong,

Humble,

Barnette

et al. 2024

BMC Public Health

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Background We assessed whether five geographic-based socioeconomic factors (medically underserved area (MUA); healthcare provider shortage area (HPSA); persistent poverty; persistent child poverty; and social vulnerability index (SVI)) were associated with the odds of HPV vaccination initiation, series completion, and parental vaccine hesitancy, and whether the observed relationships varied by gender of the child. Methods An online panel service, administered through Qualtrics®, was used to recruit parents of adolescents 9–17 years of age to complete a one-time survey in 2021. Coverage of the panel included five US states: Arkansas, Mississippi, Missouri, Tennessee, and Southern Illinois. Generalized estimating equation (GEE) models were used to assess population-level associations between five geographic-based socioeconomic factors (MUA; HPSA; persistent poverty; persistent child poverty; and SVI) and three HPV vaccination outcomes (initiation, series completion, and hesitancy). All GEE models were adjusted for age of child and clustering at the state level. Results Analyses were conducted using responses from 926 parents about their oldest child in the target age range (9–17 years). The analytic sample consisted of 471 male children and 438 female children across the five states. In adjusted GEE models, persistent child poverty and HPSA were negatively associated with HPV vaccination initiation and series completion among female children, respectively. Among male children, high social vulnerability was negatively associated with HPV vaccine series completion. Additionally, persistent poverty and high social vulnerability were negatively associated with HPV vaccine hesitancy in male children. Conclusions The results of this cross-sectional study suggest that geographic-based socioeconomic factors, particularly, HPSA, persistent poverty, and SVI, should be considered when implementing efforts to increase HPV vaccine coverage for adolescents. The approaches to targeting these geographic factors should also be evaluated in future studies to determine if they need to be tailored for male and female children.

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“…63 The HPV vaccine hesitancy escalated with the negative media reports highlighting the side effects such as dizziness, fatigue, which were later characterised as immunisation stress-related responses. 64 The same resulted in the suspension of HPV vaccination in Japan from 2013 to 2019, which was later withdrawn in 2022. 65 During this period an estimated 25,000 cases and around 5700 preventable cervical cancer deaths were reported.…”

Section: Molecular Mechanisms Behind Microbial Coinfections Causing C...mentioning

confidence: 99%

“…With the WHO/UNICEF initiative of 2030 elimination target of 90%, we have a long way to go with the existing hesitancy surrounding HPV vaccines 63 . The HPV vaccine hesitancy escalated with the negative media reports highlighting the side effects such as dizziness, fatigue, which were later characterised as immunisation stress‐related responses 64 . The same resulted in the suspension of HPV vaccination in Japan from 2013 to 2019, which was later withdrawn in 2022 65 .…”

Section: Human Papillomavirus Vaccine: Coverage Controversy and Contestsmentioning

confidence: 99%

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Ashok,

Basu,

Priyamvada

et al. 2024

Reviews in Medical Virology

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The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus‐associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co‐presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV‐associated severities.

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Human Papillomavirus Vaccine Hesitancy in the United States

Cited by 7 publications

References 50 publications

Screening for High-Risk Human Papillomavirus Reveals HPV52 and HPV58 among Pediatric and Adult Patient Saliva Samples

Screening for High-Risk Human Papillomavirus Reveals HPV52 and HPV58 among Pediatric and Adult Patient Saliva Samples

Associations of geographic-based socioeconomic factors and HPV vaccination among male and female children in five US states

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

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