Human papillomavirus vaccine and demyelinating diseases—A systematic review and meta-analysis

Mouchet, Julie; Salvo, Francesco; Raschi, Emanuel; Poluzzi, Elisabetta; Antonazzo, Ippazio Cosimo; Ponti, Fabrizio De; Bégaud, Bernard

doi:10.1016/j.phrs.2018.04.007

Cited by 34 publications

(18 citation statements)

References 54 publications

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“…Data from French nationwide databases suggested that the incidence of GBS was increased among vaccinated girls (incidence rate of 1.4 among vaccinated [20 cases] versus 0.4 per 100,000 person years among unvaccinated [23 cases]; adjusted hazard ratio: 3.78 [1.79-7.98]). Under the hypothesis of a causal relationship, this would result in 1-2 GBS cases attributable to HPV vaccine per 100,000 girls vaccinated [28]. However, based on Hospital Episode Statistics (HES), no evidence of an increased risk of GBS was found following HPV vaccination in England.…”

Section: Potential Immune-mediated Disordersmentioning

confidence: 99%

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

et al. 2020

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The Human Papillomavirus (HPV) Prevention and Control Board is an independent multidisciplinary board of international experts that disseminates relevant information on HPV to a broad array of stakeholders and provides guidance on strategic, technical and policy issues in the implementation of HPV control programs. In response to drastic drop of vaccine coverage following the adverse event crisis in Carmen del Bolivar, Colombia, the HPV Prevention and Control Board in collaboration with the Colombian National Cancer Institute and Colombian League Against Cancer convened a meeting in Bogota, Columbia (November 2018). The goal of the meeting was to bring together national and international group of experts to report the disease burden, epidemiology and surveillance of HPV and HPV-related cancers, to discuss the successes and especially the challenges of HPV vaccination and screening in Colombia, as well as the lessons learnt from neighbouring countries. The meeting provided a platform to confer various stakeholder's perspectives, including the role of the Colombian healthcare system and to catalyse various parts of the public health community in Colombia into effective action. The conclusion of the meeting included following suggestions to strengthen HPV prevention and control: 1) Reintroducing school-based vaccine programs, 2) Integrating primary and secondary prevention programs, 3) Developing an innovative crisis communication plan targeting healthcare workers, teachers and general population, 4) Building trust through efficient and timely communication, 5) Building strong relationship with media to ensure a stable vaccination campaign support, and 6) Promoting empathy among healthcare professionals towards patients to build trust and communicate effectively.

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Section: Potential Immune-mediated Disordersmentioning

confidence: 99%

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

et al. 2020

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“…Safety of HPV vaccines was studied in both clinical trials before they were licensed and through post-licensure surveillance programmes ( 224 – 233 ). Like any other vaccines administered by intramuscular route, the HPV vaccinees may get inflammation (pain, erythema, swelling and pruritus) at the injection site.…”

Section: Hpv Diseasementioning

confidence: 99%

“…No increase risk of GBS was observed following HPV vaccination in England ( 235 ). A systemic review and meta-analysis of 11 studies did not find any evidence of increased demyelinating diseases after HPV vaccination ( 233 ). However, at least 10 cases of neurological events were reported worldwide after HPV vaccination ( 236 – 241 ).…”

Section: Hpv Diseasementioning

confidence: 99%

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

Dadar

Chakraborty²,

Dhama

et al. 2018

Front. Immunol.

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Human papillomavirus (HPV) is a viral infection with skin-to-skin based transmission mode. HPV annually caused over 500,000 cancer cases including cervical, anogenital and oropharyngeal cancer among others. HPV vaccination has become a public-health concern, worldwide, to prevent the cases of HPV infections including precancerous lesions, cervical cancers, and genital warts especially in adolescent female and male population by launching national programs with international alliances. Currently, available prophylactic and therapeutic vaccines are expensive to be used in developing countries for vaccination programs. The recent progress in immunotherapy, biotechnology, recombinant DNA technology and molecular biology along with alternative and complementary medicinal systems have paved novel ways and valuable opportunities to design and develop effective prophylactic and therapeutic vaccines, drugs and treatment approach to counter HPV effectively. Exploration and more researches on such advances could result in the gradual reduction in the incidences of HPV cases across the world. The present review presents a current global scenario and futuristic prospects of the advanced prophylactic and therapeutic approaches against HPV along with recent patents coverage of the progress and advances in drugs, vaccines and therapeutic regimens to effectively combat HPV infections and its cancerous conditions.

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“…Similar results were found when MS and ON were considered separately. Sensitivity analyses did not modify conclusions (24). The safety of HPV was further demonstrated in a recent review and meta-analysis of post-licensure observational studies.…”

Section: Vaccines and Central Nervous System (Cns) Demyelinating Syndmentioning

confidence: 83%

Do Vaccines Have a Role as a Cause of Autoimmune Neurological Syndromes?

Principi

Esposito

2020

Front. Public Health

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Vaccines are the most important preventive measure against infectious diseases presently available. Although they have led to the eradication or the elimination of some infectious diseases, concerns about safety are among the main reasons for vaccine hesitancy. In some cases, the biological plausibility of a given damage in association with the temporal association between vaccine administration and disease development makes it difficult to define causality and can justify hesitancy. Only well-conducted epidemiological studies with adequate evaluation of results can clarify whether a true association between vaccines and adverse event development truly exists. Autoimmune neurological syndromes that follow vaccine use are among these. In this narrative review, the potential association between vaccines and the development of these syndromes are discussed. Literature analysis showed that most of the associations between vaccines and nervous system autoimmune syndromes that have been reported as severe adverse events following immunization are no longer evidenced when well-conducted epidemiological studies are carried out. Although the rarity of autoimmune diseases makes it difficult to strictly exclude that, albeit exceptionally, some vaccines may induce an autoimmune neurological disease, no definitive demonstration of a potential role of vaccines in causing autoimmune neurological syndromes is presently available. Consequently, the fear of neurological autoimmune disease cannot limit the use of the most important preventive measure presently available against infectious diseases.

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Human papillomavirus vaccine and demyelinating diseases—A systematic review and meta-analysis

Cited by 34 publications

References 54 publications

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

Advances in Designing and Developing Vaccines, Drugs and Therapeutic Approaches to Counter Human Papilloma Virus

Do Vaccines Have a Role as a Cause of Autoimmune Neurological Syndromes?

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