Human papillomavirus vaccine against cervical cancer: Opportunity and challenge

Wang, Renjie; Pan, Wei; Lei, Jin; Huang, Wei‐Ming; Li, Yuehan; Wu, Di; Gao, Chun; Ma, Ding; Liao, Shujie

doi:10.1016/j.canlet.2019.11.039

Cited by 300 publications

(267 citation statements)

References 189 publications

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…There are currently three types of licensed prophylactic HPV vaccines: Gardasil ® (quadrivalent vaccine targeting HPV6, HPV11, HPV16, and HPV18), Cervarix ® (bivalent vaccine targeting HPV16 and HPV 18), and Gardasil 9 ® (vaccine targeting HPV6, HPV11, HPV16, HPV18, HPV31, HPV33, HPV45, HPV52, and HPV58), approved in 2006, 2007, and 2014, respectively. The introduction of prophylactic HPV vaccines has shown a reduction in the prevalence of HPV and HPV-related diseases, such as genital warts, cervical intraepithelial neoplasia, and cervical cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

Gutiérrez‐Hoya

Soto‐Cruz²

2020

Cells

View full text Add to dashboard Cite

The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer, and the inhibition of the JAK/STAT pathway may be essential for enhancing tumor cell death. Persistent activation of different STATs is present in a variety of cancers, including cervical cancer, and their overactivation may be associated with a poor prognosis and poor overall survival. The oncoproteins E6 and E7 play a critical role in the progression of cervical cancer and may mediate the activation of the JAK/STAT pathway. Inhibition of STAT proteins appears to show promise for establishing new targets in cancer treatment. The present review summarizes the knowledge about the participation of the different components of the JAK/STAT pathway and the participation of the human papillomavirus (HPV) associated with the process of cellular malignancy.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

Gutiérrez‐Hoya

Soto‐Cruz²

2020

Cells

View full text Add to dashboard Cite

show abstract

“…Of the 40 sexually transmitted HPVs, 14 are oncogenic and are considered high-risk (7). Since the oncogenesis from infection to the development of precancerous lesions and cancer is a long and complicated process, this opens up a window of opportunity for prevention, diagnosis, and treatment (8). Early cervical cancer screening combined with HPV vaccination will effectively reduce the incidence of cervical cancer, as has been shown in many developed countries.…”

Section: Cervical Cancer and Preventionmentioning

confidence: 99%

The Extended Stability of Cervical Swabs in careHPV™ Collection Medium

Tan¹

2020

Preprint

View full text Add to dashboard Cite

Background: The careHPV™ Test is a US FDA approved, CE mark, and WHO prequalified in vitro diagnostic test that is designed to screen for 14 HRHPV genotypes. The careHPV™ Test is the only commercial HPV tests validated to be used in the low resource settings, boasting the economy of processing a maximum of 90 samples per batch and a near point-of-care turnaround time of 3 hours. Cervical swabs stored in the careHPV™ Collection Medium are stable for 30 days when stored between 2–8 °C according to the manufacturer. However, we often had difficulty to consolidate enough samples for a full batch-test within 30 days, especially when screening women living in the low-density villages in the rural Sarawak, Malaysian Borneo. Objectives: The aim of this study is to determine the stability and repeatability of cervical swabs preserved in careHPV™ Collection Medium stored at 4 °C over the recommended 30 days using the careHPV™ Test. Methods: Two groups of confirmed HRHPV positive and HRHPV negative cervical swab samples in careHPV™ Collection Medium consisting of 4 samples each were maintained at 4 °C and tested using careHPV™ Test at day-38, -123, -131, -223 and − 395. Results: All cervical swabs in careHPV™ Collection Medium stored at 4 °C remained stable for testing and demonstrated 100% repeatability for at least 395 days from the day of collection. Conclusion: The careHPV™ Test can be successfully performed on cervical swabs preserved in the careHPV Collection Medium, which are stored at 4 °C for at least 395 days.

show abstract

“…Cervical cancer is a malignant tumor, which occurs at the junction of squamous epithelial cells in the cervical vagina, or the transitional zone and columnar epithelial cells in the endometrium of the cervical canal [4]. The etiology is not totally clear, and it may be related to sexual behavior, frequency of deliveries and the infection of human papillomavirus [5,6]. The early detection and treatment of cervical cancer is very essential to the prognosis of patients with cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

Che

Yang²,

Wei

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Objective To analyze the relationship of Adler grade by transvaginal color Doppler flow imaging (TV-CDFI) and the clinical pathological parameters of patients with cervical cancer, and to identify the value of Adler grade in the diagnosis and treatment of cervical cancer. Methods Patients with cervical cancer diagnosed pathologically in our hospital from January 1, 2019 to December 31, 2019 were included, All patients underwent TV-CDFI examination, and the images were divided into 0 to III grades according to the Adler grades, and the correlations between the Adler classification and clinical pathological parameters (clinical stage, mass size, pathological type, squamous cell carcinoma subtype, CA125, CA199) were analyzed. Results A total of 162 patients with cervical cancer were included. With the increase of Adler severity, the clinical stage of cervical cancer increased accordingly. the cancer size differed significantly in patients with different Adler grade (p = 0.004); There were significant differences in the level of CA125, CA199 between the squamous cell carcinoma and adenocarcinoma (all p<0.05). the Adler grade was positively related with the clinical stage, pathological type and squamous cell carcinoma subtypes of cervical cancer (all p<0.05), no correlations were found among the Adler grade and the cancer size, CA125, CA199 (all p>0.05). The area under ROC curve of the cervical squamous cell carcinoma predicted by Adler grade based on FIGO results and pathological results was 0.811and 0.762 respectively (all p<0.05). Conclusions Adler grades are closely associated with the clinical pathology of cervical cancer, which may be a convenient and effective approach for the assisting assessment of cervical cancer.

show abstract

Human papillomavirus vaccine against cervical cancer: Opportunity and challenge

Cited by 300 publications

References 189 publications

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

The Extended Stability of Cervical Swabs in careHPV™ Collection Medium

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

Contact Info

Product

Resources

About