Human papillomavirus vaccine: A boon or curse

Chawla, Sumit; Singh, Inderjeet; Jain, Rambilas; Mehta, Bharti; Kumari, Sneh; Sahoo, Soumya Swaroop

doi:10.4161/21645515.2014.980689

Cited by 1 publication

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assuming affordable vaccine cost and knowledge of the local distribution of HPV genotypes, additional catch-up rounds may be beneficial to older HIV-infected girls, whose future access to cervical screening is uncertain and who are at risk of acquiring and transmitting multiple HPV co-infections. It has to be recognised, though, that vaccination campaigns are not meant to replace routine immunisation services if sufficient coverage is to be maintained [ 25 ] and that as female school enrolment in many countries drops after primary school, a school-based vaccination strategy may not be successful in capturing older vulnerable HIV-infected girls.…”

Section: Main Textmentioning

confidence: 99%

Determining the HPV vaccine schedule for a HIV-infected population in sub Saharan Africa, a commentary

Menon

Rossi

Kariisa

et al. 2018

Virol J

View full text Add to dashboard Cite

BackgroundEpidemiological studies have established human papillomavirus (HPV) infection as the central cause of invasive cervical cancer (ICC) and its precursor lesions. HIV is associated with a higher prevalence and persistence of a broader range of high-risk HPV genotypes, which in turn results in a higher risk of cervical disease. Recent WHO HPV vaccination schedule recommendations, along with the roll out of HAART at an earlier CD4 count within the female HIV-infected population, may have programmatic implications for sub Saharan Africa. This communication identifies research areas, which will need to be addressed for determining a HPV vaccine schedule for this population in sub Saharan Africa. A review of WHO latest recommendations and the evidence concerning one-dose HPV vaccine schedules was undertaken.ConclusionFor females ≥15 years at the time of first dose and immunocompromised and/or HIV-infected, a 3-dose schedule (0, 1–2, 6 months) is recommended for all three vaccines. There is some evidence that there is similar protection against HPV 16 and 18 infection from a single vaccination than from two or three doses, however there is no cross protection conferred to other genotypes. There is a need for periodic prevalence studies to determine the vaccination coverage of bivalent, quadrivalent and nonavalent vaccine targeted oncogenic HPV genotypes in women with CIN 3 or ICC at national level. In light of the increasing number of sub Saharan HIV-infected girls initiating HAART at a CD4 count above 350 mm3, there are a number of clinical, virological and public health research gaps to address before a tailored vaccine schedule can be established for this population.

show abstract

Section: Main Textmentioning

confidence: 99%