Human papillomavirus vaccination in low- and middle-income countries: progression, barriers, and future prospective

Ebrahimi, Narges; Yousefi, Zahra; Khosravi, Gholamreza; Malayeri, Fatemeh Eskandari; Golabi, Marjan; Askarzadeh, Monireh; Shams, Mohammad Hossein; Ghezelbash, Behrooz; Eskandari, Nahid

doi:10.3389/fimmu.2023.1150238

Cited by 32 publications

(20 citation statements)

References 105 publications

(187 reference statements)

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“…These lessons and strategies highlight the importance of tailored approaches, community engagement, and effective coordination between health and education sectors in implementing successful HPV vaccination programs. They can serve as valuable guidance for countries and regions aiming to establish or improve their HPV vaccination initiatives [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

Rathod,

Potdar,

Gupta

et al. 2023

Cureus

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This review article provides a comprehensive analysis of the role of human papillomavirus (HPV) vaccination in empowering women's health by preventing invasive cervical cancer. Cervical cancer remains a significant global health concern, with HPV infection identified as a primary causative factor. The review synthesizes current research findings, epidemiological data, and clinical outcomes to offer a nuanced understanding of the impact of HPV vaccination on cervical cancer prevention. The article explores the biology of HPV, emphasizing its association with cervical carcinogenesis and the development of precancerous lesions. It delves into the epidemiology of HPV infection, highlighting the global prevalence and the burden of cervical cancer, particularly in low-resource settings. The socio-economic factors influencing HPV transmission and cervical cancer incidence are also discussed. The focus of the review is on the efficacy and safety of HPV vaccines, including an examination of vaccine types, dosages, and long-term effectiveness. Insights into the immunological responses triggered by vaccination, as well as the duration of protection against HPV infection and associated cancers, are presented. Special attention is given to addressing myths and misconceptions surrounding HPV vaccination, aiming to enhance public awareness and acceptance. Additionally, the review discusses the impact of vaccination programs on population-wide HPV prevalence and the subsequent reduction in cervical cancer rates. It explores challenges related to vaccine accessibility, affordability, and coverage, especially in underserved populations. Strategies for improving vaccine uptake and ensuring equitable distribution are considered, with a focus on empowering women through education and healthcare access. Furthermore, the article touches upon emerging trends in HPV research, such as the development of next-generation vaccines, therapeutic interventions for existing infections, and the potential for global HPV elimination. The integration of HPV vaccination into comprehensive women's health programs is advocated, emphasizing the importance of a holistic approach to cervical cancer prevention. In conclusion, this review provides a multifaceted exploration of HPV vaccination as a pivotal tool in empowering women's health by preventing invasive cervical cancer. The synthesis of current knowledge underscores the need for continued research, education, and global collaboration to ensure the widespread success of HPV vaccination initiatives, ultimately contributing to the advancement of women's health worldwide.

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Section: Reviewmentioning

confidence: 99%

Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

Rathod,

Potdar,

Gupta

et al. 2023

Cureus

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“…[14] However, the vaccine coverage remains low, particularly in low-and middleincome settings like India; attributed to misinformation regarding vaccine safety and efficacy leading to delays in HPV vaccine adoption at the national level policies (including the Government of India) and hesitancy (at the individual level). [15] The HPV vaccines are recommended for administration preferably before initiation of sexual activity and the Indian Academy of Paediatrics (IAP) advises two doses of HPV vaccine, spaced six months apart, for boys and girls ages 9-14 years. [16] Recent successful vaccination initiatives by the state governments in Delhi, Punjab, and Sikkim highlight the prospects of successful implementation through National Immunization Schedule (NIS).…”

Section: Introductionmentioning

confidence: 99%

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

Sanjay,

Narendranath,

Seetharaman

et al. 2024

Preprint

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Background: Human Papillomavirus (HPV) infection, a prevalent sexually transmitted infection, is the leading cause of cervical cancer. However, it is preventable. Objectives:To determine the prevalence of HPV vaccine uptake among health sciences students in Coimbatore district, Tamil Nadu; and to determine the levels of knowledge and health beliefs regarding HPV infection and vaccination. Methods:This was an analytical cross-sectional study conducted among health sciences students in Coimbatore district, Tamil Nadu between November 2022, and January 2023. Results: A total of 1139 participants of mean (SD) age 19.5 years (1.5) were enrolled. More than two thirds were females (68.1%). The prevalence of HPV vaccine uptake was 5.0%; of which 87.6% were recommended by doctors. Of the 1082 participants who had not taken HPV vaccine, 35.8% were willing to take if provided free of cost. Only 4.8% participants had adequate overall knowledge regarding HPV infection and vaccination; with 9.8% having adequate general HPV knowledge, 29.3% having adequate HPV vaccine knowledge, 4.0% having adequate HPV testing, and 4.0% having adequate HPV vaccine availability knowledge. One in five (19.4%) participants had favourable/appropriate health beliefs regarding HPV infection and its vaccination – with 43.5% having perceived benefits, 39.5% having perceived sensitivity, 34.6% having perceived severity, and 19.8% having perceived obstacles. The overall HPV – Knowledge scale scores (HPV-KS) and overall HPV infection and vaccine health belief model scale (HBMS-HPVV) scores had a significant positive correlation (r=0.251; p=<0.001). Participants with employed mothers, from upper socioeconomic status, with history of HPV vaccination in the family, and uptake of HPV vaccine for self were associated with significantly higher overall HPV-KS scores. Similarly, overall HBMS-HPVV scores were significantly higher among participants from urban family residence, with literate mothers, and from upper socioeconomic status. Conclusion: The findings underscore the importance of multifaceted interventions that address knowledge gaps, dispel myths or misconceptions, and tailor messaging to resonate with diverse cultural and socioeconomic backgrounds.

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“…This reduction in prevalence leads to a decrease in infection rates among individuals who have not been vaccinated, a phenomenon known as herd protection or herd immunity. According to a recent model [5], it was projected that the objective of eradicating cancer might potentially be accomplished in low-and middle-income countries (LMICs) by attaining a 90% adoption rate for vaccination and implementing a screening programme that occurs twice in a person's lifetime by the end of the 21st century.…”

Section: Introductionmentioning

confidence: 99%

Integration of Ultrasound in Image-Guided Adaptive Brachytherapy in Cancer of the Uterine Cervix

Manea,

Chitoran,

Rotaru

et al. 2024

Bioengineering

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Cervical cancer continues to be a public health concern, as it remains the second most common cancer despite screening programs. It is the third most common cause of cancer-related death for women, and the majority of cases happen in developing nations. The standard treatment for locally advanced cervical cancer involves the use of external beam radiation therapy, along with concurrent chemotherapy, followed by an image-guided adaptive brachytherapy (IGABT) boost. The five-year relative survival rate for European women diagnosed with cervical cancer was 62% between 2000 and 2007. Updated cervical cancer treatment guidelines based on IGABT have been developed by the Gynecological working group, which is composed of the Group Européen de Curiethérapie–European Society for Therapeutic Radiology and Oncology. The therapeutic strategy makes use of three-dimensional imaging, which can be tailored to the target volume and at-risk organs through the use of computed tomography or magnetic resonance imaging. Under anaesthesia, the brachytherapy implantation is carried out. Ultrasonography is utilised to assess the depth of the uterine cavity and to facilitate the dilation of the uterine canal during the application insertion. In this study, we examine data from the international literature regarding the application of ultrasound in cervical cancer brachytherapy.

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Human papillomavirus vaccination in low- and middle-income countries: progression, barriers, and future prospective

Cited by 32 publications

References 105 publications

Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

Empowering Women’s Health: Insights Into HPV Vaccination and the Prevention of Invasive Cervical Cancer

HPV vaccine uptake, HPV infection and vaccination related knowledge and health beliefs among health sciences students in Coimbatore district, Tamil Nadu: An analytical cross-sectional study

Integration of Ultrasound in Image-Guided Adaptive Brachytherapy in Cancer of the Uterine Cervix

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