Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: A meta-analysis, 1985–2010

Jayaprakash, Vijayvel; Reid, Mary E.; Hatton, Elizabeth; Merzianu, Mihai; Rigual, Néstor R.; Marshall, James R.; Gill, Steve; Frustino, Jennifer; Wilding, Gregory E.; Loree, Thom R.; Popat, Sanjay; Sullivan, Maureen

doi:10.1016/j.oraloncology.2011.07.009

Cited by 98 publications

(96 citation statements)

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“…HPV detection rates were reported as 0% 17 and 80% 18 in studies on oral epithelial dysplasia, squamous cell carcinoma, and keratotic lesions performed in the 1990s using in situ hybridization and PCR, respectively; a more recent meta-analysis found a prevalence of 25% for HPV-16 and/or -18 by in situ hybridization and PCR. 12 Ha et al 10 detected the presence of HPV 16 DNA using real-time quantitative PCR in only 1 of 102 (1%) cases of oral premalignant lesions. Using PCR, D'Costa et al 19 detected HPV-16 in 34% of potentially malignant lesions and 31% of normal mucosa while Bouda et al 20 demonstrated high-risk HPV in oral epithelial dysplasia in all the five cases studied.…”

Section: Discussionmentioning

confidence: 99%

“…Although a recent meta-analysis calculated the prevalence of HPV-16 and/or HPV-18 in oral epithelial dysplasias to be 25%, these studies only identified the presence of HPV without investigating the expression of p16. 12 The purpose of this study is to evaluate a subset of oral epithelial dysplasias for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. …”

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Human papillomavirus-associated oral intraepithelial neoplasia

2013

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This study evaluated an unusual subset of oral epithelial dysplasia for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. There were 20 cases diagnosed as epithelial dysplasia with marked apoptosis of the anterior oral cavity. Clinical and followup data were collected and histopathological features were documented. Immunoperoxidase studies were performed for p16 and in situ hybridization studies were performed for low-and high-risk HPV sub-types. Gender-and site-matched controls of conventional moderate-to-severe oral epithelial dysplasia were similarly evaluated using immunoperoxidase studies for p16 and in situ hybridization; the number of apoptotic cells for study and control cases was counted at two different tissue sites. There were 17 men and 3 women with a median age of 56 years. Seventeen lesions were described as white and five were described as rough or papillary. Thirteen were located on the lateral or ventral tongue, some extending onto the floor of the mouth. Epithelial hyperplasia with marked karyorrhexis and apoptosis were present in all the cases, along with features of conventional oral epithelial dysplasia. A statistically significant number of apoptotic cells were identified in the study cases when compared with controls (P40.0001). Twenty cases were positive for high-risk HPV by in situ hybridization and all 19 nineteen cases evaluated for p16 demonstrated overexpression. Two patients were diagnosed with squamous cell carcinomas and one patient developed recurrent disease. We report a subset of oral epithelial dysplasia that occurs mostly in adult men on the ventral or lateral tongue and is positive for high-risk HPV and for p16. We propose use of the term 'HPV-associated Oral Intraepithelial Neoplasia' to characterize these lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract. One case recurred and one developed invasive cancer. Keywords: HPV apoptotic oral epithelial dysplasia; koilocytic dysplasiaIn the United States, smoking frequency has decreased by 16% and the overall number of cases of cancer of the oral cavity and pharynx has fallen by 18% since 1975. 1 However, rates of cancers of the oral tongue, base of tongue, and palatine tonsils have continued to rise by 2-4% among younger men. 2,3 This may, in part, be explained by the increased prevalence of a subset of oropharyngeal carcinoma associated with human papillomavirus (HPV), mostly HPV-16. 4-7 Importantly, p16 overexpression is noted in almost all HPV-associated head and neck cancers and indicates that the virus is transcriptionally active. Patients with HPV-positive, p16-positive oropharyngeal carcinomas are slightly younger than those with tumors not associated with HPV and show improved survival. 8,9 It is generally believed that HPV has only a minor role in squamous cell carcinoma of the anterior oral cavity, because it has been identified in only 2.9-5.9% of cases and the beha...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Human papillomavirus-associated oral intraepithelial neoplasia

2013

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“…15,21 HPV, particularly high-risk types 16 and 18, is the major infectious cause of oropharyngeal cancer, especially of tonsil and tongue base primaries. 22,23 The proportion of HPV-associated oropharyngeal cancers is currently growing in the Western world, with prevalence estimates in the United States approaching 80%. 6 As a result, the ratio of oropharyngeal cancer to other HN cancers is around 30% in Western practice, which is substantially different from Asian population (12%) and Thailand (< 10%).…”

Section: Oropharyngeal Cancermentioning

confidence: 99%

Epidemiology of head and neck cancer in Thailand

Tangjaturonrasme

Vatanasapt

Bychkov

2017

Asia-Pac J Clncl Oncology

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Cancer is the most common cause of death in Thailand, with the mortality almost doubled during 1998-2011 (from 48.4 to 95.2 per 100 000). The estimated number of new cancer cases in 2011 was 112 392. Our review provides baseline data on the current epidemiological situation with head and neck (HN) cancer in Thailand based on reports of the National Cancer Registry and findings from local and international publications. Collectively, HN cancer approaches agestandardized rate (ASR) incidence of 15.7 and 10.7 per 100 000 males and females, respectively, and is ranked among the top five dominant cancers in Thailand. The leading HN malignancies in men are oral (ASR incidence 4.6 per 100 000), nasopharyngeal (ASR 2.8) and laryngeal (ASR 2.7) cancers, while the most common cancers in women are thyroid (ASR 5.1) and oral (ASR 3.2) carcinomas. Some local habits (betel quid chewing, traditional cigarette smoking and alcohol intake) are associated with the high incidence of oral cancer in Northeast Thailand. Despite important prognostic significance, the role of human papillomavirus infection in various HN cancers from Thailand has been scarcely addressed. There is a growing incidence of thyroid cancer over the last two decades. The Thai population overall, compared to worldwide rates of HN malignancies, has a lower incidence of laryngeal and thyroid cancers but higher incidence of nasopharyngeal cancer. K E Y

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“…For these reasons, some consider all HPV-related neoplasia of the tonsillar crypts as potentially malignant regardless of whether or not there is clear-cut histologic evidence of stromal invasion [17]. Numerous studies have also evaluated squamous dysplasia/carcinoma in situ of the surface mucosa of the upper aerodigestive tract (mainly oral cavity but also larynx) for the presence of HPV [18][19][20][21][22][23][24][25]. However, the rates of HPV detection are widely variable between studies.…”

Section: Discussionmentioning

confidence: 99%

“…Another meta-analysis including 15 studies of oral cavity dysplastic lesions found an HPV prevalence of 25.3 % [18]. Several studies evaluated premalignant squamous lesions by HPV DNA ISH but very few studies used HPV DNA ISH combined with p16 immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

Extensive HPV-Related Carcinoma In Situ of the Upper Aerodigestive Tract with ‘Nonkeratinizing’ Histologic Features

Chernock¹,

Nussenbaum²,

Thorstad³

et al. 2013

Head and Neck Pathol

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Over the past several decades, it has become clear that human papillomavirus (HPV) is important for the development and progression of many head and neck squamous cell carcinomas, particularly those arising in the oropharyngeal tonsillar crypts. Yet, our understanding of HPV's role in premalignant squamous lesions remains relatively poor. This is in part because premalignant lesions of the oropharyngeal tonsillar crypt tissue, where most HPV-related carcinomas arise, are difficult if not impossible to identify. Recent evidence does suggest a role for HPV in a subset of premalignant lesions of the surface epithelium, especially the oral cavity, despite the rarity of HPV-related invasive squamous cell carcinomas at this site. Furthermore, these HPV-related oral cavity dysplasias appear to have unique, bowenoid histologic features described as 'basaloid' with full-thickness loss of squamous maturation, mitotic figures and apoptosis throughout. Here, we present a unique case of an HPV-related premalignant lesion (squamous cell carcinoma in situ) extensively involving the surface epithelium of the oral cavity, oropharynx and larynx that had 'nonkeratinizing' histologic features typical of HPVrelated invasive squamous cell carcinoma. This case was strongly p16 positive by immunohistochemistry and harbored transcriptionally active HPV as demonstrated by E6/E7 RNA in situ hybridization. Furthermore, the patient had an excellent response to radiation treatment.

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Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: A meta-analysis, 1985–2010

Cited by 98 publications

References 81 publications

Human papillomavirus-associated oral intraepithelial neoplasia

Human papillomavirus-associated oral intraepithelial neoplasia

Epidemiology of head and neck cancer in Thailand

Extensive HPV-Related Carcinoma In Situ of the Upper Aerodigestive Tract with ‘Nonkeratinizing’ Histologic Features

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