Human papillomavirus type distribution in women from Asia: a meta-analysis

Abstract

The aim of this study was to determine human papillomavirus (HPV) type distribution in women with and without cervical neoplasia from Asia and to estimate the potential future impact of an HPV 16/18 prophylactic vaccine in this region. A meta-analysis was conducted including 79 studies using polymerase chain reaction to detect HPV types. A total of 5954, 1653, 958, and 16,803 women with invasive cervical cancer (ICC), high-grade squamous intraepithelial lesions (HSIL), low-grade squamous intraepithelial lesions (LSIL), and normal cytology or histology were included, respectively. Type-specific prevalence of HPV types 6, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 70, 73, and 82 were estimated and stratified by cervical lesion grade. Overall HPV prevalence was 85.9%, 81.0%, 72.9%, and 14.4%, respectively, in women with ICC, HSIL, LSIL, and normal cytology/histology. In ICC, HPV 16 was the predominant type (52.4%), followed by HPV 18, 58, 33, 52, 45, 31, and 35. The estimated HPV 16/18-positive fraction was 66.9%, 40.4%, 26.7%, and 3.3% in women with ICC, HSIL, LSIL, and normal cytology or histology, respectively. In ICC, the estimated HPV 16/18-positive fraction was about 70% in all Asian geographic regions, with the exception of Japan (51.3%). HPV 16/18 vaccines are estimated to provide about 67% protection against ICC in Asia. HPV 58 and 52 were among the five most common types in ICC in eastern and southeastern Asia but not in south central Asia. After HPV 16 and 18, the next most six common HPV types were 58, 33, 52, 45, 31, and 35 that accounted for additional 20% of cervical cancer cases in Asia. For optimal population coverage, these HPV carcinogenic types should be considered for second-generation HPV prophylactic vaccines.

Prevalence of High Risk Human Papillomavirus Infection with Different Cervical Cytological Features among Women Undergoing Health Examination at the National Cancer Institute, Thailand

“…If this test is positive, immediate cervical pathology is required. In Thailand, we conducted the last version of the clinical practice guideline for cervical cancer screening and treatment follow this recommendation.The estimated HPV16/18 positive fraction was 40.4%, 26.7% and 3.3% in women with HSIL, LSIL and normal cytology (Bao, 2008). In our study, the prevalence of HPV16/18 infection was lower than of previous report in other countries.…”

Human Papillomavirus (HPV) Infection in Women Participating in Cervical Cancer Screening from 2006 to 2010 in Shenzhen City, South China

“…According to a Meta-analyse, HPV16 and 18 were the two most common genotypes among Asian women with invasive cervical cancer (ICC). Meanwhile, HPV52 and HPV58 were more common, with a suggestion of a higher proportion of HPV52 and 58 among ICC cases from eastern and southeastern Asia when compared to other geographical regions (Smith et al, 2007;Bao et al, 2008). This finding suggests that HPV bivalent vaccine or HPV quadrivalent vaccine exist some limitations.…”

Prevalence of Human Papillomavirus in Women from Saudi Arabia

“…Based on the meta-analysis reported worldwide, HPV type 16 and 18 were the most common while in (de Sanjose et al, 2007;Bruni et al, 2010), HPV type 45, 31 and 33, were in Europe and Africa. HPV 52 and 58 presented a more frequent prevalence in Asia (Bao et al, 2008;Sun et al, 2010;.…”