Human papillomavirus‐related carcinoma with adenoid cystic‐like features of the sinonasal tract: clinical and morphological characterization of six new cases

Andreasen, Simon; Bishop, Justin A.; Hansen, Thomas van Overeem; Westra, William H.; Bilde, Anders; Buchwald, Christian von; Kiss, Katalin

doi:10.1111/his.13162

Cited by 46 publications

(60 citation statements)

References 40 publications

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“…Fourteen of the cases had been previously published. (8, 10) Study approval was obtained from the Johns Hopkins University Internal Review Board (IRB00096402). The cases were all reviewed centrally (JAB) and various histologic features were characterized.…”

Section: Methodsmentioning

confidence: 99%

“…(8, 10) DNA was extracted from five micron-thick slides containing formalin-fixed paraffin-embedded tumor samples. Briefly, tissues were deparaffinized using xylene, macrodissected from the slides, and underwent digestion with 50 μg/mL proteinase K (Boehringer Mannheim) in the presence of 1% sodium dodecylsuflate at 48°C for 2 days.…”

Section: Methodsmentioning

confidence: 99%

“…(10) Adaptor-ligated amplicons were sequenced on a MiSeq (Illumina, San Diego, CA) using MiSeq reagent kit version 2 in 500 cycles (Illumina). Raw reads were subjected to a standard Basic Local Alignment Search Tool (BLAST) nucleotide search (http://blast.ncbi.nlm.nih.gov) to identify the HPV type.…”

Section: Methodsmentioning

confidence: 99%

“…(8, 10) Following hybridization, the tumor nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI) II (ZytoVision GmbH, Bremerhaven, Germany). One hundred nuclei were counted, with only nuclei where the entire nuclear membrane could be visualized scored.…”

Section: Methodsmentioning

confidence: 99%

“…(8) Since this sentinel publication, only one additional series (n=6) and a single-case report have been published. (9, 10) Given the small number of reported cases and limited clinical follow-up, the full pathologic spectrum of this tumor remains unclear and its clinical behavior remains undefined. Indeed, while “HPV-related carcinoma with adenoid cystic-like features” was included provisionally in the new WHO classification of head and neck tumors, more cases were needed to justify its inclusion as a full-fledged tumor entity.…”

Section: Introductionmentioning

confidence: 99%

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HPV-related Multiphenotypic Sinonasal Carcinoma

Bishop

Andreasen

Hang

et al. 2017

American Journal of Surgical Pathology

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HPV-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk human papillomavirus (HPV). Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is unclear. Here, we present an updated experience of 49 cases. All cases of HMSC were obtained from the authors' files. Immunohistochemistry for p16, c-kit, and myoepithelial cell markers (S100, actin, calponin, p63, and/or p40) was performed along with RNA in situ hybridization for HPV (type 33-specific as well as a high-risk cocktail). Fluorescence in situ hybridization studies for fusions of MYB, NFIB, and MYBL1 was performed on a subset of cases. Clinical follow-up was obtained from medical records. A total of 49 cases of HMSC were collected. Twenty-eight (57%) were from women and 18 (43%) from men, ranging in age from 28 to 90 years (mean, 54). Of 40 cases with detailed staging information, 43% HMSCs presented with a high T-stage (T3 or T4). Histologically, most grew predominantly as solid nests of basaloid cells exhibiting high mitotic rates and frequent necrosis, with histologic and immunohistochemical evidence of myoepithelial differentiation. Most cases also demonstrated foci of cribriform and/or tubular growth, along with an inconspicuous population of ducts. Thirty-four (69%) cases demonstrated an unusual pattern of surface involvement where markedly atypical squamous cells colonized tracts of the sinonasal mucosa. Less consistent histologic features included squamous differentiation within the invasive tumor (n=6), sarcomatoid transformation (n=5) including overt chondroid differentiation (n=3), and prominent epithelial-myoepithelial carcinoma-like growth (n=3). All cases were positive for p16 by immunostaining and HPV by RNA in situ hybridization. Thirty-three (67%) were positive for HPV 33. No cases tested for MYB, MYBL1, or NFIB gene fusions were positive. In the 38 cases with follow-up data, (mean follow-up, 42 months) 14 recurred locally and 2 metastasized (lung, finger). There were no regional lymph node metastases, and no tumor-related deaths. HMSC is a distinct sinonasal neoplasm characterized by myoepithelial differentiation, frequent surface epithelial involvement, and the presence of high-risk HPV (especially type 33). Although it classically exhibits a cribriforming pattern that closely resembles adenoid cystic carcinoma, our expanded series highlights a histologic spectrum that is much broader than previously recognized, warranting a change in terminology. HMSC usually presents as a large and destructive sinonasal mass with high-grade histologic features, but it paradoxically behaves in a relatively indolent manner, underscoring the importance of distinguishing HMSC from true adenoid cystic carcinoma, squamous cel...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

HPV-related Multiphenotypic Sinonasal Carcinoma

Bishop

Andreasen

Hang

et al. 2017

American Journal of Surgical Pathology

Self Cite

156

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The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA

Andreasen

Melchior

Kiss

et al. 2017

Cancer Cytopathology

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Case report: HPV‐related carcinoma with adenoid cystic‐like features of the sinonasal tract

2018

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Human papillomavirus-related carcinoma with adenoid cystic-like features is a newly described histologic variant of sinonasal tract carcinoma. The implications of this sinonasal malignancy is still being evaluated. There are a limited number of cases reported in the literature, and thus we seek to further characterize this patient population and review the histologic features of this malignancy with the following two cases. The behavior of this entity is as yet uncertain. Laryngoscope, 128:1515-1517, 2018.

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Human papillomavirus‐related carcinoma with adenoid cystic‐like features of the sinonasal tract: clinical and morphological characterization of six new cases

Cited by 46 publications

References 40 publications

HPV-related Multiphenotypic Sinonasal Carcinoma

HPV-related Multiphenotypic Sinonasal Carcinoma

The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA

Case report: HPV‐related carcinoma with adenoid cystic‐like features of the sinonasal tract

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