Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta‐analysis

Cour, Cecilie Dovey de la; Sperling, Cecilie Dyg; Belmonte, F.; Syrjänen, Stina; Kjær, Susanne K.

doi:10.1111/odi.13322

Cited by 31 publications

(21 citation statements)

References 25 publications

(32 reference statements)

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“…HPV has not been found to be a substantial contributor to induction of OLK, with some studies failing to detect it in a wide variety of populations over a long timeframe (Sundberg et al, 2019; Sundberg et al, 2020), while others have shown only very low positive rates of detection (<5%) with no difference to normal or OSCC samples (Della Vella et al, 2020; Yang et al, 2019). Pooled estimates of HPV prevalence in OLK (20.2%) and PVL (24.7%) were no different to other potentially malignant conditions, such as oral lichen planus (23.0%) and oral submucous fibrosis (28.6%), and were independent of OED (de la Cour, Sperling, Belmonte, Syrjänen, & Kjaer, 2020). HPV has not been found to be a driver of oncogenesis or a contributor to MT of OLK, although overexpression of p16INK4A in dysplastic epithelium has been noted (Wu et al, 2019), but found not to be HPV‐dependent (Tomo et al, 2020).…”

Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 91%

Molecular, genomic and mutational landscape of oral leukoplakia

Farah

2020

Oral Diseases

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Oral leukoplakia (OLK) and its more aggressive clinical variant proliferative verrucous leukoplakia (PVL) remain enigmatic disorders clinically and histopathologically. Despite decades of research into both, there has been only incremental advancement in our understanding of their aetiology and pathogenesis and only minimal improvement in effective management strategies. Currently, no specific prognostic genetic or molecular marker has been reported for leukoplakia. There is, however, an emerging body of evidence characterising the genomic and transcriptomic profile of OLK. Regardless of the significance of cellular and architectural features of OLK and PVL, it is clear from studies reported in this review that new emerging evidence points to the presence of premalignant molecular subtypes of leukoplakia which require further investigation. This up‐to‐date review explores the contemporary genomic, transcriptomic and mutational landscape of leukoplakia broadly, discusses concepts that may not be widely recognised or accepted and purposefully highlights studies with juxtaposed findings in an effort to challenge dogma. It also highlights the urgent need for a concerted international effort of original collaborative research which will only occur by pooling collective efforts, resources and intellect to define the molecular fingerprint of this enigmatic disorder, in the hope it will better inform diagnosis, stratification and treatment.

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Section: Clinical and Histopathological Determinants Of Malignant Tramentioning

confidence: 91%

Molecular, genomic and mutational landscape of oral leukoplakia

Farah

2020

Oral Diseases

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“…Several factors have been involved in the etiology of leukoplakia, such as HPV. De La Cour et al found an overall pooled HPV prevalence of 22.5% (95% confidence interval 16.6-29.0) across the review of 52 studies with 2677 cases [3].…”

Section: Introductionmentioning

confidence: 99%

Leukoplakia and Immunology: New Chemoprevention Landscapes?

Grigolato

Bizzoca

Calabrese

et al. 2020

IJMS

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Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations frequently characterized by an architectural and cytological derangements upon histological analysis. Among them, oral leukoplakia is the most common type of these disorders. This work aims to analyze the possible use of drugs such as immunochemopreventive agents for OPMDs. Chemoprevention is the use of synthetic or natural compounds for the reversal, suppression, or prevention of a premalignant lesion conversion to malignant form. Experimental and in vivo data offer us the promise of molecular prevention through immunomodulation; however, currently, there is no evidence for the efficacy of these drugs in the chemoprevention action. Alternative ways to deliver drugs, combined use of molecules with complementary antitumor activities, diet influence, and better definition of individual risk factors must also be considered to reduce toxicity, improve compliance to the protocol treatment and offer a better individualized prevention. In addition, we must carefully reconsider the mode of action of many traditional cancer chemoprevention agents on the immune system, such as enhancing immunosurveillance and reversing the immune evasion. Several studies emphasize the concept of green chemoprevention as an alternative approach to accent healthy lifestyle changes in order to decrease the incidence of HNSCC.

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“…Recent meta-analysis showed association of OLP with HPV but so far no implication for cancer development [ 21 ]. No association of HPV and dysplastic changes in OLP was identified [ 22 ]. Our previous study found a significant proportion of OLP being positive for HPV as well as in healthy controls [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

Radochová

Ivančaková

Heneberk

et al. 2021

IJERPH

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Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

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Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta‐analysis

Cited by 31 publications

References 25 publications

Molecular, genomic and mutational landscape of oral leukoplakia

Molecular, genomic and mutational landscape of oral leukoplakia

Leukoplakia and Immunology: New Chemoprevention Landscapes?

The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

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