Human papillomavirus prevalence and genotypes in an opportunistically screened Irish female population

Keegan, Helen; Ryan, Fergus; Malkin, Alison; Griffin, Mairead; Lambkin, Helen

doi:10.1080/09674845.2007.11732750

Cited by 12 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In cases where the CE marked LiPA assay could not resolve the exact genotype of HPV present, the sample was applied to a second LiPA assay (version 2). The HPV LiPA version 2 assay can detect the following genotypes 6,11,16 (6,11,40,43,44,54,70) and some additional types (69, 71, 74). All these assays carry a CE mark which means the assays meet European Union stringent quality controls in terms of sensitivity and reproducibility.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of social determinants on immunization programs

Cremin

Menton²,

Canier³

et al. 2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

“…Prevalence of HPV infection has been estimated to be about 20%, varying between 1.6 and 25.6% depending on geography. 6 It is estimated that approximately 80% of individuals will be infected with one or more genotypes in their lifetime. Fortunately, most infections are transient, up to 80% of infections regressing in 3 y.…”

Section: Introductionmentioning

confidence: 99%

The effect of social determinants on immunization programs

Cremin

Menton²,

Canier³

et al. 2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…It is a common infection, 70–80 % of Irish women will be infected with HPV at some stage in their life [14], although most will have the strength of immunity to clear the virus themselves [14]. In a study of 996 Irish women undergoing opportunistic cervical screening, overall HPV prevalence was 19.8 % [15]. Given recent advances in the development and mass administration of HPV vaccines, this is now a modifiable risk factor with potential to reduce the incidence of these cancers [13].…”

Section: Introductionmentioning

confidence: 99%

Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009

et al. 2016

View full text Add to dashboard Cite

BackgroundOral cancer is a significant public health problem world-wide and exerts high economic, social, psychological, and physical burdens on patients, their families, and on their primary care providers. We set out to describe the changing trends in incidence and survival rates of oral cancer in Ireland between 1994 and 2009.MethodsNational data on incident oral cancers [ICD 10 codes C01-C06] were obtained from the National Cancer Registry Ireland from 1994 to 2009. We estimated annual percentage change (APC) in oral cancer incidence during 1994–2009 using joinpoint regression software (version 4.2.0.2). The lifetime risk of oral cancer to age 79 was estimated using Irish incidence and population data from 2007 to 2009. Survival rates were also examined using Kaplan-Meier curves and Cox proportional hazard models to explore the influence of several demographic/lifestyle covariates with follow-up to end 2012.ResultsData were obtained on 2,147 oral cancer incident cases. Men accounted for two-thirds of oral cancer cases (n = 1,430). Annual rates in men decreased significantly during 1994–2001 (APC = -4.8 %, 95 % CI: −8.7 to −0.7) and then increased moderately (APC = 2.3 %, 95 % CI: −0.9 to 5.6). In contrast, annual incidence increased significantly in women throughout the study period (APC = 3.2 %, 95 % CI: 1.9 to 4.6). There was an elevated risk of death among oral cancer patients who were: older than 60 years of age; smokers; unemployed or retired; those living in the most deprived areas; and those whose tumour was sited in the base of the tongue. Being married and diagnosed in more recent years were associated with reduced risk of death.ConclusionOral cancer increased significantly in both sexes between 1999 and 2009 in Ireland. Our analyses demonstrate the influence of measured factors such as smoking, time of diagnosis and age on observed trends. Unmeasured factors such as alcohol use, HPV and dietary factors may also be contributing to increased trends. Several of these are modifiable risk factors which are crucial for informing public health policies, and thus more research is needed.

show abstract

“…The HPV mRNA type distribution is different to that reported in mRNA studies carried out in the general population in Norway, where HPV 16 was the most prevalent HPV mRNA type found, followed by: HPV 31, 33, 18 and finally HPV 45. 11,18 In the general Irish population, Keegan et al 17 found the most common types to be HPV 16 (20%) and 18 (12%) followed by HPV 66, 33, 53, 31 and 58. The differences in these cohorts may be due to the greater ethnic diversity in the HIVpositive cohort in Ireland compared to the general population in Ireland.…”

Section: Discussionmentioning

confidence: 98%

Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population

et al. 2014

View full text Add to dashboard Cite

The complex interplay between HIV and human papillomavirus and its link to cervical dysplasia is poorly understood. This is the first study to assess the prevalence of oncogenic human papillomavirus mRNA in HIV-positive women, its relationship to HIV and its potential use in the triage of cervical cancer screening in HIV-positive women. In this cross-sectional study, we included 321 HIV-positive women. In all, 28.7% had abnormal cervical cytology, 51.1% were human papillomavirus DNA-positive and 21.8% tested positive for human papillomavirus mRNA. Women with a CD4 count of <200 × 10(6)/L were more likely to test positive for human papillomavirus DNA and mRNA. Virally suppressed women were less likely to be human papillomavirus DNA-positive; however, the same did not hold true for human papillomavirus mRNA. We found the human papillomavirus mRNA screening to be more specific when screening for low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion than human papillomavirus DNA at 84.53% compared to 57.36%. However, the sensitivity was less at 51.59% versus 91.07% for human papillomavirus DNA. It may be possible in the future to use human papillomavirus mRNA/DNA testing within a triage algorithm for the screening and management of cervical cancer in the HIV-positive patient.

show abstract

Human papillomavirus prevalence and genotypes in an opportunistically screened Irish female population

Cited by 12 publications

References 0 publications

The effect of social determinants on immunization programs

The effect of social determinants on immunization programs

Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009

Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population

Contact Info

Product

Resources

About