Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

Park, Eun Kyoung; Cho, Heerim; Lee, Sun Hee; Lee, Seung-Geun; Lee, Sang Yeub; Kim, Ki Hyung; Lee, Chang-Hun; Chung, Joo Seop; Kwak, Ihm Soo

doi:10.3346/jkms.2014.29.1.32

Cited by 11 publications

(4 citation statements)

References 27 publications

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“…The proportion of multiple carcinogenic HPV types was even higher (50%, 8/16) among women with CIN2 or worse lesion. This high rate of multiple HPV infections (consistent with the rates of 12%-87.5% in previous studies in HIV-infected populations), confounds the measurement of genotype-specific fractions attributable to individual cervical disease categories [ 13 , 15 , 22 ]. A higher prevalence of multiple HPV types may be due to different reasons, including higher persistence and lower clearance of HPV in the setting of HIV infection, continued sexual exposure to novel HPV types, reactivation of latent HPV during periods of severe immune-suppression, or may be due to high relative analytical sensitivity of the PCR assay.…”

Section: Discussionsupporting

confidence: 55%

The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

Zhang

Fei

Jiang

et al. 2014

Virol J

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BackgroundYunnan has one of the oldest and the most severe human immunodeficiency virus (HIV) epidemics in China. We conducted an observational study to evaluate the human papillomavirus (HPV) genotype distribution in relation to cervical neoplastic disease risk among HIV-infected women in Yunnan.MethodsWe screened 301 HIV-infected non-pregnant women in Mangshi prefecture in Yunnan province. All consenting participants underwent simultaneous and independent assessment by cervical cytology, colposcopy-histopathology, and HPV genotyping. Unadjusted and multivariable-adjusted multinomial logistic regression analysis was conducted to evaluate factors associated with single or multiple carcinogenic HPV genotypes.ResultsHPV genotypes were present in 43.5% (131/301) overall, and carcinogenic HPV genotypes were present in 37.5% (113/301) women. Among women with carcinogenic HPV genotypes, 80 (70.8% of 113) had a single carcinogenic HPV type, while 33 (29.2%) women had multiple (2 or more) carcinogenic HPV types. Overall, the most common carcinogenic HPV types were HPV52 (7.3%), HPV58 (6.6%), HPV18 (6.3%), HPV16 (6.0%), and HPV33 (5.3%). In women with cervical precancerous lesions (i.e., high-grade squamous intraepithelial lesions [HSIL] on cytology or cervical intraepithelial neoplasia grade 2 or worse [CIN2+] detected on colposcopy-histology), the most commonly detected genotypes were HPV16 (28.6%), HPV52 (25.0%), HPV58 (17.9%), HPV18 (10.7%) and HPV31 (10.7%). Increasing age was an independent risk factor associated with presence of single carcinogenic HPV types (adjusted odds ratio: 1.04, 95%CI: 1.01-1.07, p = 0.012) but not with the presence of multiple carcinogenic types in the multivariable-adjusted models.ConclusionsAs HIV-infected women continue to live longer on antiretroviral therapy in China, it will be increasingly important to screen for, and prevent, HPV-associated cervical cancer in this population, especially given the wide diversity and multiplicity of HPV genotypes.

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Section: Discussionsupporting

confidence: 55%

The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

Zhang

Fei

Jiang

et al. 2014

Virol J

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“…This study reports for the first time the comparative prevalence and genotype distribution of HPV among HIV-1 seropositive and seronegative women in Ghana. Findings from research conducted mainly in developed countries and few studies across Africa have shown a higher prevalence of HPV infection (any HPV, hr.-HPV, multiple HPV) among HIV-1-seropositive compared with HIV-seronegative women [ 7 , 35 – 37 ]. In Ghana as elsewhere, HIV-1 seropositive women were significantly more frequently infected with HPV, and twice more likely to have high-risk and multiple HPV genotypes.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

et al. 2017

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BackgroundThere is limited data in Ghana on the epidemiology of HPV and cervical neoplasia and their associations with HIV. This study aimed to compare among HIV-1 seropositive and HIV-seronegative Ghanaian women: (1) the prevalence, genotype distribution and risk factors associated with cervical HPV infection; and (2) the prevalence and risk factors associated with abnormal cervical cytology.MethodsA comparative frequency-matched study was conducted in a systematic sample of women aged ≥18 years attending HIV and general outpatient clinics in Cape Coast Teaching Hospital, Ghana. Participants were interviewed and cervical samples collected for HPV genotyping (Seegene Anyplex-II HPV28) and cytological testing.ResultsOverall, 333 women were recruited, 163 HIV-1 seropositive and 170 HIV-seronegative women of mean age 43.8 years (SD ±9.4)) and 44.3 years (SD ±12.8), respectively. The prevalence of 14 high-risk (hr) HPV genotypes was higher among HIV-1 seropositive women (65.6% vs. 30.2%, P < 0.0001), as was proportion with multiple hr.-HPV infections (60.6% vs. 21.3%, P < 0.0001). HPV35 was the most prevalent hr.-HPV genotype in both groups (11.9% and 5.3%). The main factors associated with hr.-HPV infection were age for HIV-positive women and circumcision status of main sexual partner for both HIV-negative and positive women.Abnormal cervical cytology prevalence was higher among HIV-1 seropositive women (any SIL: 14.1% vs. 1.2%, P < 0.0001; low-grade SIL [LSIL]: 4.9% vs. 0.6%, P = 0.02; high-grade SIL: 1.8% vs. 0%, P = 0.07). Among HIV-1 seropositive women, number of pregnancies and CD4+ cell count were associated with LSIL+ cytology. There was strong association between LSIL+ abnormalities and HPV35 (aOR = 4.7, 95%CI: 1.3–17.7, P = 0.02).ConclusionsHIV-1 infected women bear significant burden of HPV infection and related disease. Prevention and screening programmes should be specifically deployed for this population in Ghana.Electronic supplementary materialThe online version of this article (10.1186/s12885-017-3682-x) contains supplementary material, which is available to authorized users.

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“…The prevalence of human papilloma virus (HPV) infection, which causes cervical cancer, is also high among Korean women with HIV. Given that the high-risk HPV genotype which often causes cervical cancer is prevalent, regular screening for cervical cancer is required [ 16 ]. According to the ‘The Korea HIV/AIDS Cohort Study’, the positive rate was 6.09% for hepatitis B antigen (HBsAg) and 1.78% for hepatitis C antibody (anti-HCV Ab).…”

Section: Clinical Characteristics Of Hiv Infection In Koreamentioning

confidence: 99%

History of Acquired Immune Deficiency Syndrome in Korea

Kim

Choi

et al. 2020

Infect Chemother

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The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. A total of 12,522 infected individuals have been reported up to 2015, of which 2,020 died. The male to female ratio was 15.4:1, and 34.2% of them were under 30 years old. The infection route was homosexual and bisexual contact in 60.1% of cases and heterosexual contact in 34.6% of cases. Candidiasis, Pneumocystis pneumonia, tuberculosis were common as a AIDS (acquired immune deficiency syndrome)-defining illness. But with the introduction of antiretroviral therapy in the late 1990s, non-AIDS defining illnesses such as metabolic complications, cardiovascular diseases, bone diseases, and neuropsychiatric disorders such as neurocognitive dysfunction, depression, and anxiety are emerging as new health problems. The management policy switched its focus from regulating and monitoring of HIV-infected persons to ensuring access to treatment and promotion of voluntary HIV testing in high-risk groups. Also as the age of the infected persons increases, a need for various supports such as social rehabilitation, life counseling, and welfare has emerged.

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Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

Cited by 11 publications

References 27 publications

The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

Epidemiology of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL) among a cohort of HIV-infected and uninfected Ghanaian women

History of Acquired Immune Deficiency Syndrome in Korea

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