Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology

Giuliani, Eugenia; Rollo, Francesca; Donà, Maria Gabriella; Garbuglia, Anna Rosa

doi:10.3390/pathogens10111411

Cited by 11 publications

(6 citation statements)

References 142 publications

(247 reference statements)

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“…In comparison to HPV 225, HPV 223 was less prevalent among this cohort which corroborates with our initial findings where the presence of HPV 223 and 225 were 0.97% and 9.7% in skin, respectively, among Caucasian subjects 9 . Prevalence of gamma‐HPV in mucosal epithelium‐like cervix, oral, and genital warts are previously reported in few studies where gamma‐HPVs were found either in a coinfected state with other HPVs or in an independent infectious state among Caucasian women and men 25–28 . In our study the prevalence of α‐HPV in oral mucosa of normal and diseased participants were found to be 7.3% and 26%, respectively, whereas, a previous study from our lab reported their prevalence to be 14% and 32% in normal and oral cancer patients respectively 29 .…”

Section: Discussionsupporting

confidence: 92%

“…On the contrary, prevalence of HPV 225 was predominantly seen in the keratinized epithelium, that is, the sun-exposed skin and breast skin of normal participants followed by previously reported in few studies where gamma-HPVs were found either in a coinfected state with other HPVs or in an independent infectious state among Caucasian women and men. [25][26][27][28] In our study the prevalence of α-HPV in oral mucosa of normal and diseased participants were found to be 7.3% and 26%, respectively, whereas, a previous study from our lab reported their prevalence to be 14% and 32% in normal and oral cancer patients respectively. 29 Although, diseased participants showed more α-HPV prevalence in their oral mucosa but coinfection with HPV 223 was found in a single normal participant and HPV 225 was present in two normal participants only.…”

Section: Discussioncontrasting

confidence: 78%

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Prevalence of novel gamma HPV types 223 and 225 in oral cavity and skin of Indian normal and neoplastic participants

Chatterjee

Sultana

Roy

et al. 2023

Journal of Medical Virology

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Gamma‐papillomaviruses, though traditionally classified as cutaneotropic, actual tissue tropism is largely unexplored. This study aimed to evaluate the tissue‐specific prevalence of two novel‐HPV 223 and 225 in samples of oral mucosa and keratinized epithelium of varied skin parts from 226 female and male subjects, with or without neoplastic/dysplastic lesions in oral cavity or cervix. The gamma‐human papillomavirus (gamma‐HPV) 223 and 225 DNA presences were determined by polymerase chain reaction (PCR) ursing the HPV type‐specific primers and confirmed by Sanger sequencing. Viral load in the HPV 223 and HPV 225 positive samples were determined by absolute real‐time quantification method. Alpha‐HPV DNA prevalence was also checked in oral mucosa to ascertain coinfection status. Novel HPV 223 was present in 4.4% (10/226) oral mucosal samples of the study population; interestingly all were females with no prevalence in their corresponding skin swab samples. Whereas, the prevalence of HPV 225 was found both in the skin and oral mucosa of 28.2% (N = 37/131) female and 17.9% (N = 17/95) male participants. Alongside, HPV 223 viral load was found to be significantly higher (p = 0.02 < 0.05) in the oral mucosa of diseased participants, whereas, HPV 225 viral load was higher in the oral mucosa of normal participants. Our results suggest that gamma‐HPV 223 has its prevalence only in the oral mucosal epithelium, whereas, HPV 225 has its prevalence on both mucosal and keratinized skin epithelium, indicating its dual tropism nature.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 78%

Prevalence of novel gamma HPV types 223 and 225 in oral cavity and skin of Indian normal and neoplastic participants

Chatterjee

Sultana

Roy

et al. 2023

Journal of Medical Virology

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“…The keratinized penis epithelium is more resistant to HPV infection, and the amount of biological fluid that reaches the oropharynx can also be a factor in this gender difference [ 30 ]. Finally, it appears that women develop a stronger systemic immune response than men after a genital HPV infection [ 31 ]. This would more efficiently protect women than men in the case of subsequent exposure to HPV.…”

Section: Oral–cervical–perinatal Hpv Transmissionmentioning

confidence: 99%

“…In women aged 18 to 69 years, data from oral and cervicovaginal HPV DNA screening showed that cervicovaginal HPV infection was present in 45.2%, oral HPV infection in 4.1%, double infection in 3.0%, and concordant infection in 1.1%. Nearly half of U.S. men have HPV infection of the penis [ 31 ]. High burden of HPV infection of the penis has been associated with oral HPV infection.…”

Section: Oral–cervical–perinatal Hpv Transmissionmentioning

confidence: 99%

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Dellino,

Pinto,

D’Amato

et al. 2024

JCM

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Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18–24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.

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“…Human papilloma virus (HPV) infection is a risk factor for carcinoma in the oropharyngeal, genital, and anal regions [15,16]. Especially the high-risk (hr) HPV alpha types HPV-16 and − 18 are commonly encountered in mucosal carcinomas [17]. High prevalence of gynecologic HPV infections has been detected in females with CHH [18].…”

Section: Introductionmentioning

confidence: 99%

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

Arponen,

Vakkilainen,

Tomnikov

et al. 2024

Orphanet J Rare Dis

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Background Cartilage-hair hypoplasia (CHH) is a rare syndromic immunodeficiency with metaphyseal chondrodysplasia and increased risk of malignancy. In this cross-sectional observational study, we examined HPV status and oral microbiome in individuals with CHH. Oral brush samples were collected from 20 individuals with CHH (aged 5–59 years) and 41 controls (1–69 years). Alpha HPVs (43 types) were tested by nested PCR followed by bead-based probe hybridization. Separately, beta-, gamma-, mu- and nu- HPV types were investigated, and a genome-based bacterial microbiome sequencing was performed. Results We found a similar alpha HPV prevalence in individuals with CHH (45%) and controls (36%). The HPV types of individuals with CHH were HPV-16 (25%), 27, 28, and 78, and of controls HPV-3, 16 (21%), 27, and 61. Beta HPV positivity and combined beta/gamma/mu/nu prevalence was detected in 11% and 11% of individuals with CHH and in 5% and 3% of the controls, respectively. Individuals with CHH differed from the controls in bacterial microbiota diversity, richness, and in microbial composition. Individuals with CHH had lower abundance of species Mitsuokella sp000469545, Parascardovia denticolens, Propionibacterium acidifaciens, UMGS1907 sp004151455, Salinicola halophilus, Haemophilus_A paraphrohaemolyticus, Fusobacterium massiliense, and Veillonella parvula, and higher abundance of Slackia exigua. Conclusions Individuals with CHH exhibit similar prevalence of HPV DNA but different bacterial microbiota on their oral mucosa compared to healthy controls. This may partly explain the previously observed high prevalence of oral diseases in CHH, and regular oral examination is warranted.

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Human Papillomavirus Oral Infection: Review of Methodological Aspects and Epidemiology

Cited by 11 publications

References 142 publications

Prevalence of novel gamma HPV types 223 and 225 in oral cavity and skin of Indian normal and neoplastic participants

Prevalence of novel gamma HPV types 223 and 225 in oral cavity and skin of Indian normal and neoplastic participants

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

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