Human Papillomavirus Investigation of Patients with Cervical Intraepithelial Neoplasia 3, Some of Whom Progressed to Invasive Cancer

Shah, Keerti V.; Kessis, Theodore D.; Shah, Farida; Gupta, Jean W.; Shibata, Darryl; Jones, Ronald W.

doi:10.1097/00004347-199604000-00006

Cited by 22 publications

(13 citation statements)

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“…Although infection with HPV, particularly the highrisk genotypes, has been shown to be an essential initiating event for the etiopathogenesis and development of preinvasive lesions of the cervix, relatively few will progress to invasive carcinoma if left untreated (5,(20)(21)(22) . Because ablative treatment modalities employing electrocautery, cryotherapy, or laser will increase the risk of cervical stenosis and cervical incompetence, identifying CINs with little potential for progression to invasive cancer would have a significant clinical impact (9) .…”

Section: Discussionmentioning

confidence: 99%

Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis

Yang

Zhang

et al. 2006

International Journal of Gynecological Cancer

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Tumor suppressor in lung cancer 1 (TSLC1) is a tumor suppressor gene in non-small cell lung cancer, and loss of TSLC1 gene expression has been observed in a number of epithelial carcinomas and cancer-derived cell lines. We analyzed TSLC1 gene expression by real-time reverse transcription-polymerase chain reaction in 39 invasive cervical carcinomas, 34 cervical intraepithelial neoplasia (CIN) IIIs, 35 CIN IIs, 32 CIN I, 36 inflammation cervical tissues, and 30 normal cervix samples. Loss of TSLC1 gene expression was observed in 30 of 39 (77%) cervical carcinomas, 25 of 34 (73%) CIN IIIs, 9 of 35 (26%) CIN IIs, and 7 of 32 (22%) CIN Is but was not found in inflammation and normal cervix samples. Compared to normal cervical tissue, loss of TSLC1 gene was significantly high in CIN IIIs and cervical cancer (P = 0.00). Moreover, loss of TSLC1 gene expression is observed at a significantly higher frequency in CIN IIIs and cervical cancers than in CIN IIs (P < 0.05). The results show that loss of TSLC1 gene expression is an early event in cervical carcinogenesis and often accompanies invasive cervical cancers.

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Section: Discussionmentioning

confidence: 99%

Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis

Yang

Zhang

et al. 2006

International Journal of Gynecological Cancer

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“…Estimates of the prevalence of SILs range from 0.5% to 6.5% of the U.S. female population, including >50,000 new cases of carcinoma in situ each year. However, it is estimated that only 12% to 22% of high-grade SILs (HSIL) will progress to invasive carcinoma if left untreated (3)(4)(5). Morphologic examination alone does not allow distinction of those HSILs likely to progress from those that will regress or simply persist (3).…”

Section: Introductionmentioning

confidence: 99%

Expression of Membrane Type 1 Matrix Metalloproteinase Is Associated with Cervical Carcinoma Progression and Invasion

Zhai¹,

Hotary²,

Nan

et al. 2005

Cancer Research

101

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Membrane type 1 matrix metalloproteinase (MT1-MMP) is frequently expressed by cancer cells and is believed to play an important role in cancer cell invasion and metastasis. However, little is known about the role of MT1-MMP in mediating invasiveness of cervical cancer cells. In this study, we examined MT1-MMP expression in 58 primary human cervical tissue specimens, including normal cervix, low-grade squamous intraepithelial lesions (LSIL), high-grade SILs (HSIL), and invasive carcinomas. We also evaluated MT1-MMP, MMP-2, and tissue inhibitor of metalloproteinase-2 expression in several cervical cancer-derived cell lines, human papillomavirus (HPV)-immortalized keratinocytes, and keratinocytes derived from a LSIL. Using in situ hybridization techniques to study the cervical tissue specimens, we found that MT1-MMP expression increases with cervical tumor progression (Spearman correlation coefficient = 0.66; P < 0.0001, exact test). Specifically, MT1-MMP expression is very low or absent in normal cervix and LSILs, is readily detectable in HSILs, and is very strongly expressed in nearly all invasive carcinomas. Most but not all cervical cancerderived cell lines also expressed significant levels of MT1-MMP and MMP-2. Constitutive expression of exogenous MT1-MMP in cervical carcinoma-derived cells and HPVimmortalized keratinocytes with low endogenous levels of MT1-MMP induced invasiveness in collagen I, but this effect was not observed in LSIL-derived keratinocytes. Our results show that MT1-MMP is a key enzyme mediating cervical cancer progression. However, MT1-MMP alone is not always sufficient for inducing keratinocyte invasiveness at least in the collagen I invasion assay used in this study. Further studies of gene expression in preinvasive and invasive cervical cancers should assist with identification of additional critical factors mediating cervical cancer progression. (Cancer Res 2005; 65(15): 6543-50)

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“…В комплексном лечении CIN используется иммунокорригирующая и фо-тодинамическая терапия с высокой противоопухолевой и пролонгированной противовирусной активностью [13][14][15][16]. Однако существующая в настоящее время тактика ле-чения пациенток с преинвазивной цервикальной патоло-гией не обеспечивает снижения частоты развития инва-зивного рака [17][18][19][20]. Для повышения эффективности терапии необходима комплексная реабилитация репро-дуктивного здоровья женщин [21][22][23].…”

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Efficiency of treatment in women with severe cervical dysplasia in different age periods

Aminodova¹,

Posiseeva²

2015

Ross. vestn. akush.-ginekol.

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Human Papillomavirus Investigation of Patients with Cervical Intraepithelial Neoplasia 3, Some of Whom Progressed to Invasive Cancer

Cited by 22 publications

References 0 publications

Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis

Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis

Expression of Membrane Type 1 Matrix Metalloproteinase Is Associated with Cervical Carcinoma Progression and Invasion

Efficiency of treatment in women with severe cervical dysplasia in different age periods

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