Human Papillomavirus Infections in Nonmelanoma Skin Cancers From Renal Transplant Recipients and Nonimmunosuppressed Patients

Shamanin, V A; Hausen, Harald zur; Lavergne, Donna; Proby, Charlotte M.; Leigh, Irene M.; Neumann, Christine; Hamm, Henning; Goos, M.; Haustein, U.‐F.; Jung, Ernst G.; Plewig, Gerd; Wolff, Helmut H.; Villiers, Ethel Michele De

doi:10.1093/jnci/88.12.802

Cited by 281 publications

(270 citation statements)

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“…The cancers in EV individuals predominantly occur at body sites exposed to sunlight, pointing to a role for ultra violet (UV) radiation in the development of the disease (Orth et al, 1979). In addition to EV, a role for HPVs has also been postulated in the development of non-melanoma skin cancers (NMSC) in both immunocompetent and immunocompromised individuals, such as organ transplant recipients (Jablonska, 1990;Purdie et al, 1993;de Jong-Tieben et al, 1995;Shamanin et al, 1996;Hop¯et al, 1997;Surentheran et al, 1998). Interestingly, these individuals also often develop NMSC at UV-exposed sites (reviewed in Proby et al, 1996).…”

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confidence: 99%

“…For these experiments we chose three di erent HPV types: the EVassociated HPV5 (group B1); a low risk cutaneous type, HPV10 (group A2); and HPV77, a group A2 type related to HPV10 which was originally identi®ed in both warts and SCCs of a renal transplant recipient (Shamanin et al, 1994;Delius et al, 1998). The E6 gene from each of the viruses was ampli®ed by PCR and subcloned into the expression vector pcDNA3 and were veri®ed by DNA sequencing.…”

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confidence: 99%

“…These patients are exposed to chronic as well as acute UV doses and whose cutaneous lesions, including both warts and cancers, frequently harbour a diverse spectrum of HPV sequences (Shamanin et al, 1994(Shamanin et al, , 1996Berkhout et al, 1995;de Jong-Tieben et al, 1995). Although HPV10 is usually associated with benign proliferations in immunocompetent and immunosuppressed individuals (Favre et al, 1989;Obalek et al, 1992;Shamanin et al, 1994) it has also been found in carcinomas in organ transplant recipients in which the lesions are often multiply infected (Storey et al, 1998). The fact that the HPV10 E6 protein also inhibited UV-induced apoptosis, suggests that this function may facilitate HPV proliferation.…”

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RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

2000

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In addition to their role in anogenital cancer, human papillomaviruses (HPVs) are also involved in the development of a range of cutaneous lesions. HPV types 5 and 8 are associated with the development of skin cancers in individuals with Epidermodysplasia verruciformis (EV). A broad spectrum of HPV types are also commonly found in non-melanoma skin cancers in immunocompromised individuals, such as organ transplant recipients. The skin cancers in EV and immunocompromised patients occur predominantly at body sites exposed to ultra violet (UV) radiation, pointing to a key role for UV in their development. Here we show that the E6 protein from a range of cutaneous HPV types e ectively inhibits apoptosis in response to UV damage. This occurs in both p53 null and wild type cells and does not require p53 degradation. Oncogene (2000) 19, 592 ± 598.

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RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

2000

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“…The possible misclassification by actinic lesions can be ruled out; we should take into account that sporadic warts (the only ones that cannot be misclassified because actinic lesions do not disappear) are associated with the risk of LC. Furthermore, there is evidence of a causal relation in cervix cancer and a high prevalence of viral infection in the tumour in the case of oral cancer, even in nonmelanoma skin cancer (Shamanin et al, 1996).…”

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Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

et al. 2003

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The aim of this study was to identify factors related to lip cancer (LC) considering individual characteristics and sociodemographic factors. A case -control study was carried out in the province of Granada (Andalusia, southern Spain). The cases were 105 males with squamous-cell carcinoma of the lip, diagnosed between 1987 and 1989 (aged 20 -70 years) and identified by means of a populationbased Cancer Registry. As controls, a randomised populational sample of 239 males, stratified by age, was used. Multiple logistic regression analysis showed that risk factors are lifetime cumulative tobacco consumption and alcohol consumption. An interaction was found between alcohol consumption and the smoking habit (leaving the cigarette on the lip): OR ¼ 23.6; 95% CI: 3.9 -142.0. Other risk factors identified are clear eyes (OR ¼ 3.5; CI: 95% 1.5 -8.0), sun exposure early in life and cumulative sun exposure during outdoor work (OR ¼ 11.9; 95%: CI: 1.3 -108.9), and skin reaction to sun exposure (Fitzpatrick levels). Another interaction was found between skin reaction and a previous history of common sporadic warts (OR ¼ 4.4; 95% CI: 1.01 -19.1). We conclude that LC is related to phenotype, skin reaction to sun exposure, cumulative and early sunlight exposure, and tobacco and alcohol consumption, as well as a low educational level. Leaving the cigarette on the lip is predictive of LC risk irrespective of cumulative tobacco consumption.

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“…They vary in tissue distribution, oncogenic potential and association with anatomically and histologically distinct diseases (zur Hausen, 1996). Based on the ability to infect the skin or mucosa of the anogenital and respiratory tracts, the HPVs fall into two groups, cutaneous and mucosal genotypes (de Villiers, 1997).…”

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Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma protein

2000

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Studies on human papillomavirus type 16 have demonstrated that the product of the early gene, E7, plays a key role in the immortalization and malignant transformation of the host cell. Several of the biological activities of HPV16 E7 are mediated by inactivation of the members of the pocket protein family, pRb, p107 and p130. In this study, we have characterized the in vitro properties of ®ve E7 proteins from benign and malignant HPV types (10, 32, 48, 54, 77). We show that these E7 proteins associate with pRb and p107 with di erent e ciencies. All E7s increased the proliferative rate of immortalized rodent ®broblasts cultured in 10% calf serum containing medium. This property is completely independent of their ability to associate with the pocket proteins. Furthermore, all E7s, except HPV10 E7, stimulate G1/S progression and activated the cyclin E and cyclin A promoter in the absence of growth factors. This activity also does not correlate with the E7-e ciency of binding the pocket proteins. Together these data provide evidence that di erent E7s alter the regulation of the cell cycle by diverse mechanism(s). Finally, this comparative analysis of the di erent E7 proteins demonstrates that the oncogenicity of a HPV type is not determined by the ability of E7 to associate with the pocket proteins. Oncogene (2000) 19, 821 ± 826.

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Human Papillomavirus Infections in Nonmelanoma Skin Cancers From Renal Transplant Recipients and Nonimmunosuppressed Patients

Abstract: The presence of HPV DNA in a large percentage of specimens of nonmelanoma carcinomas of the skin from immunosuppressed patients, as well as from nonimmmunosuppressed patients, renders a papillomavirus infection as a possible factor in the etiology of this disease.

Cited by 281 publications

References 32 publications

RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

Lifestyles, environmental and phenotypic factors associated with lip cancer: a case–control study in southern Spain

Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma protein

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