Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: Type-specific prevalence and HPV coinfections

Aguilar‐Lemarroy, Adriana; Vallejo-Ruíz, Verónica; Cortés‐Gutiérrez, Elva I.; Salgado-Bernabé, Manuel Eduardo; Ramos-González, Norma Patricia; Ortega-Cervantes, Laura; Arias-Flores, Rafael; Medina-Díaz, Irma Martha; Hernández-Garza, Fernando; Santos‐López, Gerardo; Piña‐Sánchez, Patricia

doi:10.1002/jmv.24099

Cited by 48 publications

(41 citation statements)

References 78 publications

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“…On the other hand, Aguilar-Lemarroy et al, in an analysis of 822 samples, found HPV16 to be the most prevalent type in all the studied groups, as in the study by Salcedo et al 21 , but also identified HPV18, HPV45, HPV52, HPV58, and HPV39 types 22 .…”

Section: Concurrent Infectionsmentioning

confidence: 58%

“…It should be noted that HPV16 was only found in three coinfections and HPV18 was not found at all. Aguilar-Lemarroy et al also found HPV16 more frequently, associated in coinfection with types 18, 39, and 70 in samples from cervical cancer 22 . Remarkably, none of the samples in our study contained any of the high-risk HPV types, including single, double, and triple infections.…”

Section: Concurrent Infectionsmentioning

confidence: 89%

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Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

Jácome-Galarza¹,

Ito-Nakashimada

Figueroa-Aguilar

et al. 2017

RIC

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Background: Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries. Objective: The objective of the study is to know the prevalence and genotypes of HPV in women from the state of Michoacán and the Women's Hospital in Morelia, Michoacán. Materials and Methods: Cervical smear samples (159,288) were subjected to HPV detection by hybrid capture 2. A subsample of 484 patients from the Women's Hospital was studied by Papanicolaou test and linear array HPV genotyping, and when positive, patients were also examined by colposcopy and histopathology. Results: The overall prevalence for HPV in Michoacán State was 7.74%; 7.11% in 2009, 6.46% in 2010, 9.58% in 2011, and 8.43% in 2012. The highest prevalence was found in the age groups < 25 and 25-34 years. The prevalence at the Women's Hospital was 8.51%. Cytological examination revealed normal cytology in 64.44% of samples, 26.66 % with low-grade and 8.88 % with high-grade squamous intraepithelial lesion (HSIL). However, by colposcopy, normal tissue appearance was found only in 26.66%; 51% were reclassified as low-grade squamous intraepithelial lesion, 17.77% as HSIL, and in 4.4% atrophy was observed. The most prevalent genotype in single infections was HPV59, followed by HPV51 and HPV45. Double infections occurred with the following genotypes:

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Section: Concurrent Infectionsmentioning

confidence: 58%

Section: Concurrent Infectionsmentioning

confidence: 89%

Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

Jácome-Galarza¹,

Ito-Nakashimada

Figueroa-Aguilar

et al. 2017

RIC

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“…In 2015, HPV16 presented the highest frequency in cervical tumors (57%), while HPV18 showed a minor frequency (< 8%) in agreement with HPV incidence worldwide [4]. Nevertheless, HPV types 31, 45, 52, and 58 were also detected in Mexican females, suggesting an important and unattended factor for CeCa and HPV infection control [4,5].…”

Section: Introductionmentioning

confidence: 68%

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

Rangel-Guerrero¹,

Basilio

Rocío

et al. 2020

SN Compr. Clin. Med.

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Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and a necessary condition for cervical cancer (CeCa) development. HPV types 16 and 18 are the most common in cervical lesions (CLs); therefore, specific vaccines have reduced cervical neoplasia. In 2015, HPV16 presented the highest frequency in CLs (~28%); however, types 31, 45, 52, and 58 were also detected, suggesting that other HPV types may have impact on healthcare. Here, we typified 30 patients with CLs from the "Hospital Regional 1°de Octubre" (HR1O), in Mexico City, for the most reported high-risk papillomavirus (HPV16, 18, 31, 33, 45, 58, and 59). The results showed that HPV16 frequency is dissimilar to international and previous national data, suggesting that a deeper knowledge of HPV type distribution is required before choosing a vaccination scheme for HPV in Mexico City.

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“…In Northeast Brazil, HPV62 prevalence among the overall population was of 3.6% and in Korea, 2% of atypical squamous cell and low-grade squamous intraepithelial lesions were HPV62 positive [32, 33]. In Mexico, a IMSS Research Network report on HPV, including 822 women, found HPV62 infection in 3.1% of women without cervical lesions, in 5.1% with CIN1, in 6.7% with CIN3 and in 0.8% in CC samples [14]. …”

Section: Discussionmentioning

confidence: 99%

“…The E6 (447 bp), E7 (291 bp) and L1 (1512 bp) genes from this HPV62 reference genome (8092 bp) encode for 148, 96 and 503 amino acid proteins, respectively. In a first report including cervical samples from mexican population, HPV62 was mainly detected in coinfection with other HPV genotypes and it was found in 5.1% of HPV positive patients with Cervical Intraepithelial Neoplasia Grade 1 (CIN1) and in 0.8% of HPV positive patients with CC using Linear Array HPV Genotyping test [14]. The aim of this study, was to determine the prevalence of this genotype in a greater number of samples among Mexican women and to detect possible mutations in L1, E6 and E7 genes of the HPV62 circulating in the Mexican population.…”

Section: Introductionmentioning

confidence: 99%

Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico

Artaza‐Irigaray

Flores-Miramontes

Olszewski

et al. 2017

Infect Agents Cancer

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BackgroundHuman papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV genotypes is associated with premalignant lesions and cervical cancer development. HPVs considered as low risk or not yet classified, are often found in coinfection with different HPV genotypes. Indeed, HPV62 is one of the most prevalent HPV detected in some countries, but there is limited information about its prevalence in other regions and there are no HPV62 variants currently described. The aim of this study was to determine the prevalence of HPV62 in cervical samples from Mexican women and to identify mutations in the L1, E6 and E7 genes, which have never been reported in our population.MethodsHPV screening was performed by Cobas HPV Test in women who attended prevention health programs and dysplasia clinics. All HPV positive samples (n = 491) and 87 additional cervical cancer samples were then genotyped with Linear Array HPV Genotyping test. Some samples were selected to corroborate genotyping by Next-Generation sequencing. On the other hand, nucleotide changes in L1, E6 and E7 genes were determined using PCR, Sanger sequencing and analysis with the CLC-MainWorkbench 7.6.1 software. L1 protein structure was predicted with the I-TASSER server.ResultsUsing Linear Array, HPV62 prevalence was 7.6% in general population, 8% in Cervical Intraepithelial Neoplasia grade 1 (CIN1) samples and 4.6% in cervical samples. The presence of HPV62 was confirmed with Next-Generation sequencing. Regarding L1 gene, novel sequence variations were detected, but they did not alter the tertiary structure of the protein. Moreover, several nucleotide substitutions were found in E6 and E7 genes compared to reference HPV62 genomic sequence. Specifically, three non-synonymous sequence variations were detected, two in E6 and one in E7.ConclusionsHPV62 is a frequent HPV genotype found mainly in general population and in women with CIN1, and in 90.5% of the cases it was found in coinfection with other HPVs. Novel nucleotide changes in its L1, E6 and E7 genes were detected, some of them lead to changes in the protein sequence.

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Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: Type-specific prevalence and HPV coinfections

Cited by 48 publications

References 78 publications

Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

Prevalence of Human Papillomavirus in Women from the State of Michoacan, Mexico, Showed High Frequency of Unusual Virus Genotypes

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico

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