Human papillomavirus infection of the cervix; Relative risk associations of 15 common anogenital types

Lorincz, A.; Reid, R; Ab, Jensen; Greenberg, MD; Lancaster, W; Rj, Kurman

doi:10.1016/0020-7292(92)90921-5

Cited by 339 publications

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“…HPV types 16 and 18 constitute almost 90% of cervical cancers in India and the presence of other high risk types is very low or nil (Das et al, 1992a, b;Gopalkrishna et al, 2000;Franceschi et al, 2005). It has been reported that 10 -35% of normal healthy women harbour HPV DNA in their cervical epithelium depending on the screening method, age of the women, number of subjects studied and their geographic locations (Lorincz et al, 1986(Lorincz et al, , 1992Toorn et al, 1986). In the present study only 5% of normal control tissues (n ¼ 40) compared to 18% of (n ¼ 10) normal cervical scrapes were positive for HR-HPV types 16/18 infection.…”

Section: Discussionmentioning

confidence: 99%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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Telomerase is a ribonucleoprotein comprising an RNA template, the telomerase-associated protein and its catalytic subunit, human telomerase reverse transcriptase (hTERT). Telomerase activation is a critical step in cellular immortalisation and development of cancer. Enhanced telomerase activity has been demonstrated in cervical cancer. In the present study telomerase activity and hTERT mRNA expression were evaluated and correlated with the presence of human papillomavirus (HPV) infection and cytological changes in the cervical lesions. Telomerase activity was assayed by telomeric repeat amplification protocol, hTERT mRNA expression by reverse transcriptase polymerase chain reaction and presence of high risk HPV (HR-HPV) infection by polymerase chain reaction. Out of 154 cervical samples of different cytology, 90 (58.44%) were positive for HR-HPV types 16/18, while among 55 normal cervical scrapes, 10 (18.18%) were HPV DNA positive. All 59 invasive cancer samples showed a very high telomerase activity. Among dysplasia, seven (63.6%) mild dysplasia, 18 (100%) of moderate, 20 (100%) of severe dysplasia and 6 (100%) carcinoma in situ (CIS) samples were positive with mild to moderate to high to very high telomerase activity respectively. Seven (12.7%) samples of apparently normal cervical scrapes were weakly positive for telomerase activity. We observed a good correlation (Po0.001) between telomerase activity and HR-HPV 16/18 positivity with a sensitivity of 88.1% for HPV and 100% for telomerase activity. It is suggested that telomerase activity may be used as an adjunct to cytology and HPV DNA testing in triaging women with cervical lesions.

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Section: Discussionmentioning

confidence: 99%

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

et al. 2006

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“…However, only a fraction of precancerous lesions progress to ICC. A strong candidate factor for differential progression is HPV type (Lorincz et al, 1992).Identifying HPV types that preferentially progress from highgrade squamous intraepithelial lesions (HSIL) to ICC has implications not only for follow-up protocols in ICC screening programmes, but also for prophylactic type-specific HPV vaccine trials. For ethical reasons, final outcome measures in such trials will be the prevention of HSIL.…”

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confidence: 99%

Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

et al. 2003

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Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials. (Walboomers et al, 1999). However, only a fraction of precancerous lesions progress to ICC. A strong candidate factor for differential progression is HPV type (Lorincz et al, 1992).Identifying HPV types that preferentially progress from highgrade squamous intraepithelial lesions (HSIL) to ICC has implications not only for follow-up protocols in ICC screening programmes, but also for prophylactic type-specific HPV vaccine trials. For ethical reasons, final outcome measures in such trials will be the prevention of HSIL. However, it is important to know whether the HPV type distribution in HSIL is representative of those that go on to cause cancer.Articles presenting HPV type-specific prevalence data were identified from Medline. Studies had to include at least 20 cases of squamous cell or histologically unspecified cervical cancer (Clifford et al, 2002) and/or 20 histologically verified cases of HSIL. In this study, HSIL refers both to lesions classified by the Bethesda system, that is, CIN2/3, and those classified separately as CIN2 and CIN3. Studies had to use polymerase chain reaction (PCR)-based assays to identify HPV, and to present prevalence of at least one type other than HPV6, 11, 16 or 18 (Clifford et al, 2002).This report includes 8594 squamous cell carcinoma of the cervix (SCC) cases (including 2725 of unspecified histology), as previously reported in Clifford et al (2002), and 4338 HSIL cases (1733 reported as CIN2/3, 1824 as CIN3, 729 as CIN2 and 52 as cervical carcinoma in situ)(detailed information on the HSIL studies is reported in the Appendix). Compared to SCC, cases of HSIL were more likely to be from (i) Europe and South/Central America rather than other regions, (ii) studies that detected HPV from exfoliated cells rather than biopsy specimens and (iii) studies that used 'broad'-spectrum (MY09/11, GP5 þ /6 þ and SPF10) rather than other PCR primers (Table 1).Type-specific prevalence is presented for the 14 most common high-risk (HR) types identified in SCC ( Table 2). As not all studies tested for all 14 types, sample size varies between type-specific analyses. Type-specific prevalence is expressed as a percentage of all cases tested for HPV, and thus represents the prevalence in either single or multiple infections.Overall, HPV prevalence was slightly higher in SCC cases (87.6%) than HSIL (84.2%) (SCC : HSIL ratio 1.04, 95% CI 1.03 -1.06) ( T...

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“…8 Conversely, it is well known that human papillomavirus (HPV) infection plays a crucial role in the development of various preneoplastic and neoplastic cervical lesions and the progression of these lesions largely depends on the infection of high-risk HPV subtypes such as HPV-16, HPV-18, HPV-31,etc. 9,10 Therefore, the detection of HPV subtypes in these lesions is clinically useful for evaluating a patient's prognosis. 11 However, to date, Ͼ 80 subtypes of HPV have reportedly been identified, and 18 of these subtypes have been reported to be high-risk subtypes.…”

mentioning

confidence: 99%

Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing

Yoshida

Fukuda

Sano

et al. 2004

Cancer

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Human papillomavirus infection of the cervix; Relative risk associations of 15 common anogenital types

Cited by 339 publications

References 0 publications

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer

Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing

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