Human Papillomavirus Infection–Associated Adenoid Cystic Carcinoma of the Hard Palate

Chung, Arthur Minwoo; Sun, Dong Il; Jung, Eun Sun; Lee, Youn Soo

doi:10.4132/jptm.2016.07.07

Cited by 1 publication

(1 citation statement)

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“…10 In the nasal cavity, for example, an entity of human papillomavirus (HPV)-associated carcinoma with ACC-like features has been recently described and shown to have favorable prognosis. 16,17 If any of the cases in this study had a similar pathology, it could potentially explain the high survival rates seen in this study. With this in mind, adequate biopsy tissue for HPV testing is important in diagnosis, even if nonsurgical treatment is anticipated.…”

Section: Discussionmentioning

confidence: 81%

Adenoid Cystic Carcinoma of the Skull Base: Response to Radiation Therapy and Outcomes in a Retrospective Case Series

Gadkaree

Parikh

Rodarte

et al. 2019

J Neurol Surg B Skull Base

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Objectives The main purpose of this article is to examine a single-center cohort of patients with nasopharyngeal adenoid cystic carcinoma (ACC) for pathologic features, skull base invasion, overall survival, and disease-free survival, with a focus on response to proton beam radiation therapy. Design, Setting, and Participants Single-center institutional cancer registry was used to retrospectively identify and analyze outcomes for 12 patients treated for ACC of the nasopharynx from 2000 to 2016. Main Outcomes and Measures Primary outcomes included 5-year overall survival and locoregional control. Statistical analysis was performed using STATA 12.0 (STATACorp, College Station, Texas, United States). Spearman's rank order correlation was used for ordinal, monotonic variables with p-values <0.05 considered statistically significant. Survival analysis was performed by Kaplan–Meier method; comparison between groups was performed using log-rank test. Results Twelve patients with ACC of the nasopharynx were included. All patients presented with advanced disease and were treated with primary radiation therapy, typically proton beam therapy. Only two underwent a surgical attempt at resection. A majority of cases had a cribriform growth pattern. The 5-year survival was 75% and rate of locoregional control rate at 5 years was 50%, comparable to other ACC cohort studies that included earlier stage tumors in various subsites that were surgically resected. Conclusions Although ACC is traditionally noted to be radioresistant, ACC of the nasopharynx was responsive to radiotherapy in our cohort, despite advanced stage and skull base invasion. Reasons for this improved survival are unclear and suggest the need for further pathologic and genetic characterization of nasopharyngeal ACC.

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Section: Discussionmentioning

confidence: 81%