Human papillomavirus infection and squamous cell carcinoma of the conjunctiva

Ateenyi-Agaba, Charles; Franceschi, Silvia; Wâbwire-Mângen, Fred; Arslan, Annie; Othieno, Emmanuel; Binta-Kahwa, J; Doorn, L-J van; Kleter, Bernhard; Quint, Wim; Weiderpass, Elisabete

doi:10.1038/sj.bjc.6605466

Cited by 73 publications

(70 citation statements)

References 17 publications

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“…Human papillomavirus and human immunodeficiency virus have also been cited as possible cofactors in OSSN that may influence the prognosis. 3,[18][19][20] Recurrence developed in 17% of 48 patients herein with follow-up data, which is similar to that in other studies (17%-41%). 1,7 Larger tumors (2 cm) and those with a diffuse growth pattern had a higher risk of recurrence.…”

Section: Correlation Of Clinicopathological Features With Recurrence-supporting

confidence: 80%

American Joint Committee on Cancer Staging and Clinicopathological High-Risk Predictors of Ocular Surface Squamous Neoplasia: A Study From a Tertiary Eye Center in India

Chauhan¹,

Sen²,

Sharma³

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Ocular surface squamous neoplasia (OSSN) is the most common tumor of conjunctival epithelium associated with risk of permanent visual impairment. It includes conjunctival intraepithelial neoplasia and squamous cell carcinoma. Although American Joint Committee on Cancer-TNM (AJCC-TNM) staging is commonly used in various tumors, it has only recently been described for OSSN.Objectives.-To evaluate the prognostic relevance of AJCC-TNM staging and the clinicopathological features in OSSN.Design.-Sixty-four histopathologically proven cases of OSSN (20 conjunctival intraepithelial neoplasia and 44 squamous cell carcinoma) were included in the study. The AJCC-TNM staging and clinicopathological features of OSSN cases were recorded. Patients were followed up for 17 to 40 months (median, 32 months). Univariate and multivariate analyses were performed to determine the prognostic value of various clinicopathological features.Results.-Longer sunlight exposure (P ¼ .01), diffuse growth pattern (P ¼ .02), larger tumor size (2 cm) (P ¼ .03), histopathological diagnosis of squamous cell carcinoma (P ¼ .02), and orbital invasion or invasion of adjacent structures (T3 or T4) (P , .001) emerged as significant predictors of reduced recurrence-free survival. Using multivariate analysis, a higher T category (T3 or T4) was the most important prognostic indicator of a poor outcome.Conclusions.-A higher T category (T3 or T4) is an important predictor of clinical outcome, and the use of the AJCC-TNM staging system is recommended in the management of all patients with OSSN. Longer sunlight exposure, larger tumor size (2 cm), orbital invasion or invasion of adjacent structures (T3 or T4), and a histopathological diagnosis of squamous cell carcinoma are other clinicopathological features of prognostic relevance in patients with OSSN.

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Section: Correlation Of Clinicopathological Features With Recurrence-supporting

confidence: 80%

American Joint Committee on Cancer Staging and Clinicopathological High-Risk Predictors of Ocular Surface Squamous Neoplasia: A Study From a Tertiary Eye Center in India

Chauhan¹,

Sen²,

Sharma³

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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“…2 HPV infection is present in up to half of the cases. 36 There appears to have been no reduction in the steady increase in incidence in Kampala, despite modest declines in HIV prevalence, and increasing use of ART. It has been observed that in addition to human papilloma virus, sunlight exposure in equatorial region is a major aetiological factor of SCCC in patients with severe immunesuppression.…”

Section: Epidemiologymentioning

confidence: 99%

Trends in the incidence of cancer in Kampala, Uganda 1991-2010

et al. 2014

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The Kampala cancer registry is the longest established in Africa. Trends in incidence rates for a 20-year period (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) for Kyadondo County (Kampala city and a rural hinterland) illustrate the effects of changing lifestyles in urban Africa, and the effects of the epidemic of HIV-AIDS. There has been an overall increase in the risk of cancer during the period in both sexes, with incidence rates of major cancers such as breast and prostate showing particularly marked increases (3.7% and 5.2% annually, respectively). In the 1960s cancer of the oesophagus was the most common cancer of men (and second in women), and incidence in the last 20 years has not declined. Cancer of the cervix, always the most frequent cancer of women, has shown an increase over the period (1.8% per year), although the rates appear to have declined in the last 4 years. HIV prevalence in adults in Uganda fell from a maximum in 1992 to a minimum (about 6%) in 2004, and has risen a little subsequently, while availability of antiretroviral drugs has risen sharply in recent years. Incidence of Kaposi sarcoma in men fell until about 2002, and has been relatively constant since then, while in women there has been a continuing decline since 2000. Other HIV related cancers-non-Hodgkin lymphoma of younger adults, and squamous cell carcinoma of conjunctiva-have shown major increases in incidence, although the former (NHL) has shown a small decline in incidence in the most recent 2 years. IntroductionKampala Cancer Registry (KCR) was established in 1954 with the aim of obtaining information on cancer occurrence in the population of Kyadondo County which includes Kampala city the capital of Uganda. 1 The registry is located in the Department of Pathology of the Makerere University College of Health Sciences, and achieved adequate coverage of the population in 1960. However, after 10 years, registration activity became confined to the recording of pathology diagnoses, during the period of dictatorship and civil war in the 1970s and 1980s. Full coverage of the Kyadondo population was achieved again in 1989 and has continued since then. 2The registry provides the longest time series of cancer incidence in Africa. This makes the data of special value of cancer surveillance and research, particularly in monitoring the epidemic of HIV/AIDS and as a baseline for analytical studies and intervention studies. Screening programmes are now in existence especially for cancer of the cervix, as a consequence of the very high incidence rates recorded by the registry in previous reports.In a previous paper 3 we presented cancer incidence data from KCR for a 16-year time period (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). Here we update this analysis, including more recent data, to identify the consistency or otherwise of the previously observed trends. Materials and MethodsSubmission to the registry is volun...

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“…In African case series there is a high prevalence of DNA HPV 6 and 11, but not HPV 16 and 18 (Verma et al, 2008). On the other hand, in a series reported recently in Uganda, HPV 5 and 8 were the most common in nearly half of OSSN (Ateenyi-Agaba, et al, 2010). We have detected the presence of DNA HPV type 11.…”

Section: Human Papilloma Virus (Hpv) Detectionmentioning

confidence: 49%