Human papillomavirus infection and colorectal cancer in the Chinese population: a meta‐analysis

Abstract

The results indicated that HPV infection, especially HPV 16 and HPV 18, is associated with colorectal cancer in the Chinese population.

Detection of Human papillomavirus and the role of p16INK4a in colorectal carcinomas

“…Studies involving cases and controls show a higher frequency of the virus in the tumor tissue, but there are few investigations that use the non-tumor tissue adjacent to the tumor as a control (HPV prevalence ranging from 0% to 13.4%) [43,[57][58][59][60] as investigated in this study, or even other healthy colonic tissues (HPV prevalence ranging from 0% to 5.8%) [39,57]. With regard to precursor lesions, low prevalence of HPV is described in the reviewed studies (0% to 31%) [40,43,44,56,[61][62][63].…”

“…Genotyping was performed by reverse hybridization using the INNO-LiPA HPV Genotyping Extra II Kit (Fujirebio Europe 1 ). The assay allows the identification of 32 HPV genotypes, currently known as high risk genotypes [16,18,31,33,35,39,45,51,52,56,58,59,68], probable high risk [26,53,66,70,73,82] and low risk [6,11,40,42,43,44,54,61,62,67,81,83,89].…”

“…There is a high discrepancy in the literature regarding the results of HPV prevalence in CRCs, ranging from 0 to 84.2% [39,[41][42][43][44]56]. Studies involving cases and controls show a higher frequency of the virus in the tumor tissue, but there are few investigations that use the non-tumor tissue adjacent to the tumor as a control (HPV prevalence ranging from 0% to 13.4%) [43,[57][58][59][60] as investigated in this study, or even other healthy colonic tissues (HPV prevalence ranging from 0% to 5.8%) [39,57].…”

“…Three meta-analyzes on the detection of HPV in CRC have already been published, with results of combined prevalence of 11.2% (95% CI, 4.9-19.6) [43]; 31.9% (95% CI, 19.3-47.9) [41], and 45% (95% CI, 0.36-0.53) [56]. Baandrup (2014) included eight case-control studies and the overall prevalence of HPV was 36.8% in adenocarcinomas, 5.1% in adenomas; 13.4% in non-cancer tissues adjacent to the tumor and 1.6% in tissues free of disease.…”

“…The results of the meta-analyzes should be interpreted with great care, mainly due to the heterogeneity of the samples, HPV detection methods, geographical differences and possible contamination of the tumor samples during clinical processing, observations that the authors themselves highlighted in their studies [41,43,56].…”