Human Papillomavirus Infection and Cancer Risk in Peri- and Postmenopausal Women

Vieira‐Baptista, Pedro; Preti, Mario; Bornstein, Jacob

doi:10.1007/978-3-030-13936-0_4

Cited by 2 publications

(4 citation statements)

References 139 publications

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“…This study complements those findings by evidencing a moderator effect of the HPV type (low/high risk) and infection duration in this modality regarding the evolution of worries and concerns. Supporting previous literature (Hsu et al, 2018), age had a significant effect, that is, young women are more vulnerable to the impact of a positive diagnosis, which may be due to the fact that HPV is a condition much more prevalent in young woman, with increased severity of cervical lesions in this group (Hao et al, 2020; Vieira-Baptista et al, 2019).…”

Section: Discussionsupporting

confidence: 71%

“…A previous study has shown that no condom use is related to emotional suppression and sexual dissatisfaction in woman with HPV diagnosis (Leite et al, 2019). Age is also another factor associated with the HPV infection since the prevalence decreases after the age of 25 and increases after 50 (Vieira-Baptista et al, 2019). A previous study has shown that the HPV impact on QoL is more substantial in older women (Leite et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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HPV-related quality of life in diagnosed women: A longitudinal study

et al. 2022

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This paper explored changes in the HPV-related quality of life (QoL) of 209 women diagnosed with human papillomavirus (HPV) during 1 year of medical monitoring, at three time points (6-month interval between them). Participants completed the HPV Impact Profile (HIP) questionnaire to assess HPV-related QoL. The relationship between HIP scores and time was moderated by the HPV risk type and infection duration: an HPV diagnosis had a stronger negative effect on patients with an HPV high-risk type and on those living with HPV for a long period of time. Age, condom use, motherhood, and type of family were significant predictors.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

HPV-related quality of life in diagnosed women: A longitudinal study

et al. 2022

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“…This misperception tends to reduce their engagement in regular screening and lowers their awareness of potential diseases, subsequently increasing the incidence of cervical cancer. [3] High-grade squamous intraepithelial lesions (HSIL) are detectable during cervical cancer screenings, and effectively treating HSIL can significantly reduce the incidence of cervical cancer. [4] HSIL may naturally progress through 3 potential outcomes: regression, persistence, or progression.…”

Section: Introductionmentioning

confidence: 99%

“…However, a subsequent increase is observed in women between the ages of 50 and 60, most of whom are either perimenopausal or postmenopausal. [ 3 ] Factors such as previous cervical screenings or the experience of becoming widowed may lead these women to mistakenly perceive themselves as being at a lower risk. This misperception tends to reduce their engagement in regular screening and lowers their awareness of potential diseases, subsequently increasing the incidence of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the clinical characteristics and surgical methods of high-grade squamous intraepithelial lesions of the cervix in postmenopausal women: A retrospective case study

Zhao,

Zhang,

Song

et al. 2024

Medicine

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The purpose of this study was to thoroughly evaluate the clinical features and surgical options for high-grade squamous intraepithelial lesions (HSIL) in postmenopausal women. A total of 308 patients diagnosed with HSIL through colposcopic cervical biopsy and endocervical curettage were included. Their clinical characteristics, surgical treatments, and postoperative pathology were analyzed. Key findings include: 1. Patients with positive preoperative thinprep cytologic test (TCT) results and postoperative pathology indicating HSIL or squamous cell carcinoma (≥HSIL) were significantly more frequent than those with negative preoperative TCT results (P < .05). 2. Univariate analysis indicated significant impacts of TCT, human papillomavirus (HPV) type, transformation zone (TZ) location, and surgical technique on postoperative pathology (P < .05). 3. Logistic regression analysis confirmed significant influences of TCT, HPV type, TZ location, and surgical method on postoperative pathology outcomes (P < .05), showing that each unit increase in TZ raised the probability of ≥HSIL in postoperative pathology by 49.7%. In surgical comparisons, cold knife conization (CKC) and extrafascial hysterectomy resulted in 8.379 and 4.427 times higher probabilities of ≥HSIL in postoperative pathology, respectively, compared to loop electrosurgical excision procedure (LEEP). 4. Surgical methods significantly influenced margin results (P < .05). After LEEP, 17.5% of cases had positive margins, compared to 9.4% after CKC, and 3.7% after extrafascial hysterectomy, indicating the highest rate of positive surgical margins occurred with LEEP. 1. Combined TCT and HPV screening is crucial for cervical cancer prevention, early detection, and management in postmenopausal women. Women with positive results for both TCT and HPV should undergo colposcopic cervical biopsy and endocervical curettage. 2. For patients with TZ3, CKC is the recommended surgical option. 3. CKC is the preferred treatment for postmenopausal women with HSIL, as it effectively diagnoses and treats the lesion, showing superior outcomes in managing postmenopausal HSIL.

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Human Papillomavirus Infection and Cancer Risk in Peri- and Postmenopausal Women

Cited by 2 publications

References 139 publications

HPV-related quality of life in diagnosed women: A longitudinal study

HPV-related quality of life in diagnosed women: A longitudinal study

Analysis of the clinical characteristics and surgical methods of high-grade squamous intraepithelial lesions of the cervix in postmenopausal women: A retrospective case study

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