Human Papillomavirus Infection Among 2460 Men in Denmark

Hebnes, Julie B.; Munk, Christian; Nøhr, Bugge; Nielsen, Ann; Jørgensen, Hans Ole; Iftner, Thomas; Kjær, Susanne K.

doi:10.1097/olq.0000000000000315

Cited by 22 publications

(9 citation statements)

References 29 publications

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“…In addition, the Denmark study showed the highest HPV infection prevalence among men aged 20 to 29 years in contrast to our study, which demonstrated a lower prevalence among younger groups, with a higher and persistent prevalence among older age groups. It may be that the cumulative prevalence of persistent infections would be expected to increase with age, as was shown in oral HPV infection .…”

Section: Discussioncontrasting

confidence: 99%

“…This pattern of infection is similar to the prevalence of oral HPV infection from the NHANES 2009-2010 previously reported . The overall HPV prevalence is similar to recent research from Denmark, which reported a 41.8% overall HPV prevalence, with the same high-risk HPV subtype 51 as the most prevalent . In female individuals, the most prevalent HPV subtype was 53, and subtype 51 was the fourth most common .…”

Section: Discussionsupporting

confidence: 87%

“…15 The overall HPV prevalence is similar to recent research from Denmark, which reported a 41.8% overall HPV prevalence, with the same high-risk HPV subtype 51 as the most prevalent. 22 In female individuals, the most prevalent HPV subtype was 53, and subtype 51 was the fourth most common. 21 Furthermore, the most prevalent HPV subtype may not reflect the putative potency of carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Genital Human Papillomavirus Infection and Human Papillomavirus Vaccination Rates Among US Adult Men

et al. 2017

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Genital Human Papillomavirus Infection and Human Papillomavirus Vaccination Rates Among US Adult Men

et al. 2017

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“…Details on this cross-sectional study have been described previously. 32 Briefly, male personnel at a number of military barracks in Denmark were invited to participate in the study. All men received approximately €25 for their participation and gave their informed consent.…”

Section: Methodsmentioning

confidence: 99%

The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark

et al. 2021

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It is crucial to understand the natural history of genital human papillomavirus (HPV) infection in men to prevent the increasing male HPV-related disease burden. We evaluated the associations between HPV infection and circumcision, smoking, and alcohol use after accounting for sexual behavior. The study included 2331 male personnel from Danish barracks. Penile swabs were tested for HPV DNA with a polymerase chain reaction assay, INNO-LiPA. All men completed a self-administered questionnaire providing data on potential risk factors for HPV such as lifestyle and sexual habits. Using multivariable logistic regression, associations between potential risk factors and HPV infection were estimated and expressed as odds ratios (ORs) with 95% confidence intervals (CI). Current cigarette smoking was associated with increased odds of HPV detection (OR = 1.2; 95% CI: 1.0–1.4), but we found no association with alcohol use in the analysis adjusted for sexual behavior. Circumcision reduced the odds of a prevalent HPV infection (OR = 0.7; 95% CI: 0.5–1.0) although not statistically significantly. Strong associations with lifetime and recent number of female sex partners were observed, but in contrast to uncircumcised men, increasing number of sex partners was not associated with higher HPV prevalence in circumcised men. In conclusion, smoking was associated with increased odds of penile HPV in men from the general population in Denmark, whereas circumcision seemed to reduce the risk. Moreover, our results indicated that there might be differences in the viral susceptibility between circumcised and uncircumcised men.

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“…For Denmark, publicly-available prevalence estimates were available for HCV 39 and HIV 38 . For EBV 36 and HPV 42 , we used published seroprevalence and qPCR positivity estimates, respectively, as proxies for overall prevalence. When in-country estimates weren't available, we resorted to the best data source from a country or region with similar demographics, such as Switzerland (BKV) 45 , the Netherlands (MCV, CMV) 34,47 , Northern Europe (AAV-2) 43 , or Germany (HSV-1) 32 .…”

Section: Discussionmentioning

confidence: 99%

Inferring the sensitivity of wastewater metagenomic sequencing for pathogen early detection

Grimm,

Kaufman,

Rice

et al. 2023

Preprint

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Detecting novel pathogens at an early stage requires robust early warning that is both sensitive and pathogen-agnostic. Wastewater metagenomic sequencing (W-MGS) could meet these goals, but its sensitivity and financial feasibility depend on the relative abundance of novel pathogen sequences in W-MGS data. Here we collate W-MGS data from a diverse range of studies to characterize the relative abundance of known viruses in wastewater. We then develop a Bayesian statistical model to integrate these data with epidemiological estimates for 13 human-infecting viruses, and use it to estimate the expected relative abundance of different viral pathogens for a given prevalence or incidence in the community. Our results reveal pronounced variation between studies, with estimates differing by one to three orders of magnitude for the same pathogen: for example, the expected relative abundance of SARS-CoV-2 at 1% weekly incidence varied between 10-7and 10-10. Integrating these estimates with a simple cost model highlights similarly wide inter-study and inter-pathogen variation in the cost of W-MGS-based early detection, with a mean yearly cost estimate of roughly $19,000 for a Norovirus-like pathogen and $2.9 million for a SARS-CoV-2-like pathogen at 1% incidence. The model and parameter estimates presented here represent an important resource for future investigation into the performance of wastewater MGS, and can be extended to incorporate new wastewater datasets as they become available.

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Human Papillomavirus Infection Among 2460 Men in Denmark

Cited by 22 publications

References 29 publications

Prevalence of Genital Human Papillomavirus Infection and Human Papillomavirus Vaccination Rates Among US Adult Men

Prevalence of Genital Human Papillomavirus Infection and Human Papillomavirus Vaccination Rates Among US Adult Men

The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark

Inferring the sensitivity of wastewater metagenomic sequencing for pathogen early detection

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