Human Papillomavirus‐Induced Verrucous Carcinoma of the Mouth

Guitart, Joan; McGillis, S. Teri; Bailin, Philip L.; Bergfeld, Wilma F.; Rogers, Roy S.

doi:10.1111/j.1524-4725.1993.tb01022.x

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…On the other hand, patients with widespread lesions are candidates for systemic therapies like aminopterin, acitretin, etretinate, levamisole, interferon, and methotrexate, but rapid recurrences are not infrequent 6,16–19 . Radiotherapy has been another successfully used therapeutic option in the past but today is excluded because of the risk of anaplastic transformation 5,20 …”

Section: Discussionmentioning

confidence: 99%

“…6,[16][17][18][19] Radiotherapy has been another successfully used therapeutic option in the past but today is excluded because of the risk of anaplastic transformation. 5,20 In recent years several authors have reported good results with long durations of remissions with CO 2 laser surgery, especially in patients with widespread, chronic, and resistant disease. 11,21,22 In our patient, many treatment modalities were tried with inadequate results, but the CO 2 laser surgery and recombinant-alfa-2b interferon combination therapy resulted in complete remission, and no recurrence occured within a follow-up period of 2 years.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the term multifocal papillomavirus epithelial hyperplasia (MPVEH) has been proposed to define the variant that usually occurs in childhood and is characterized by diffuse confluent papillomatous lesions in the oral mucosa 1 . Despite the lesions’ benign appearance, early diagnosis and therapy of MPVEH is essential because of its high capacity for progression and its tendency for malign degeneration 5–7 …”

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confidence: 99%

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Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b

Akyol

Anadolu

et al. 2003

Int J Dermatology

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Human papilloma virus (HPV) infections of the oral mucosa presents with various clinical and histopathologic features in relation with the causative HPV type and chronicity and the extent of the infection.1 The entity is known by several names based on histopathologic variations such as focal epithelial hyperplasia, oral florid papillomatosis, verrucous hyperplasia, oral florid verrucosis, and Ackerman's tumor. In recent years, the term multifocal papillomavirus epithelial hyperplasia (MPVEH) has been proposed to define the variant that usually occurs in childhood and is characterized by diffuse confluent papillomatous lesions in the oral mucosa.1 Despite the lesions' benign appearance, early diagnosis and therapy of MPVEH is essential because of its high capacity for progression and its tendency for malign degeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b

Akyol

Anadolu

et al. 2003

Int J Dermatology

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“…The presence of HPV in verrucous carcinomas has been analyzed by several authors [3,4,33,42,43,46,49,62] with the detection rate of 37.7% (60/159; range 0-100%) (summarized in [68]). Interestingly, the most prevalent HPV type was HPV 6/11 (47%), followed by HPV 16/18 (35.3%) and HPV 2 (17.7%).…”

Section: Hpv and Verrucous Carcinomamentioning

confidence: 99%

“…Of the almost 100 known HPV types, at least the following 25 types have been detected in oral lesions: 1,2,3,4,6,7,10,11,13,16,18,31,32,33,35,40,45,52,55,57,58,59,69,72,73. During the past several years, comprehensive reviews have been published on HPV infections in oral lesions [15,21,27,45,54,73,74,77,85].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infections and oral tumors

Syrjänen

2003

Medical Microbiology and Immunology

145

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In the past 20 years, there has been an increasing interest in human papillomaviruses (HPV) because of their potential role in the pathogenesis of malignant tumors. In 1983, we published the first evidence that HPV might be involved in oral squamous cell carcinomas. The identification of morphological similarities between oral and cervical mucosa lead us to this original proposal. In a recent meta-analysis, HPV was indeed confirmed as an independent risk factor for oral carcinoma. To date, totally more than 100 types of HPV have been identified. As in anogenital cancers, HPV type 16 is the most prevalent type in oral carcinomas. The benign oral lesions, associated with HPV infection, include squamous cell papilloma, condyloma acuminatum, verrucca vulgaris and focal epithelial hyperplasia (FEH). Papillomas and condylomas are mostly caused by HPV type 6 or 11, while oral verrucas are associated with the skin types 2 or 4. A family history of FEH has been suggested. The FEH lesions are caused by HPV types 13 and 32, only detected in oral epithelium. In immunocompromised patients, benign HPV-induced lesions are characterized by atypical morphology and the simultaneous detection of multiple HPV types. Oral benign HPV lesions are mostly asymptomatic, and may persist or regress spontaneously.

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HPV in Head and Neck Cancer—30 Years of History

Syrjänen

Rautava

Syrjänen

2016

HPV Infection in Head and Neck Cancer

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The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Parsons and Kidd described the natural history of oral PV infections in rabbits already in 1942, but these findings were corroborated in humans only recently. Koilocytotic atypia described by Koss and Durfee in 1956 was recognized as a sign of HPV infection in cervical precancer lesions only in 1976-1977 (Meisels and Fortin; Purola and Savia). This prompted systematic surveys of head and neck lesions for the detection of koilocytosis since the late 1970s, and the authors of this communication were the first to propose the HPV involvement in a subgroup of head and neck cancers. Brandsma and Abramson demonstrated HPV16 DNA in tonsillar SCCs in 1989. Since the early 2000s, HPV research of head and neck squamous cell carcinomas (HNSCC) has made impressive progress, confirming that the specific anatomic site plays a key role in determining the susceptibility to HPV infection. The most likely cancer sites associated with HPV are the base of the tongue and palatine tonsils, followed by oral cavity, larynx, and sinonasal mucosa. There is substantial geographic variation in HPV association with HNSCC. Patients with HPV-associated HNSCC are younger, and survival is better than in the absence of HPV.

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Human Papillomavirus‐Induced Verrucous Carcinoma of the Mouth

Cited by 9 publications

References 20 publications

Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b

Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b

Human papillomavirus infections and oral tumors

HPV in Head and Neck Cancer—30 Years of History

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Human Papillomavirus‐Induced Verrucous Carcinoma of the Mouth

Cited by 9 publications

References 20 publications

Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha‐2b

Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha‐2b

Human papillomavirus infections and oral tumors

HPV in Head and Neck Cancer—30 Years of History

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Product

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Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b

Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO₂ laser therapy combined with interferon alpha‐2b