Human papillomavirus in sinonasal papillomas and squamous cell carcinoma

Abstract

The diagnostic and prognostic relevance of human papillomavirus (HPV) types 6, 11, 16, and 18 in squamous papilloma, inverted papilloma, and squamous carcinoma of the sinonasal epithelium was examined using the polymerase chain reaction (PCR) technique. Four (15%) of 26 squamous papillomas, 7 (24%) of 29 inverted papillomas, and 1 (4%) of 24 squamous carcinomas were positive for HPV when examined using the PCR amplification technique. Human papillomavirus 6 was present in 5 specimens (3 squamous and 2 inverted papillomas); HPV-11 was present in 6 specimens (1 squamous and 5 inverted papillomas); and HPV-18 was present in 1 of 24 squamous carcinomas. HPV-16 was not identified in any specimen. The proportion of tissue samples showing HPV presence, and the association of HPV types 6 and 11 with benign lesions and HPV-18 with malignant lesions, are both in accord with findings from prior investigations. Two major questions regarding nasal papilloma are the probability for lesion recurrence after surgical excision and the risk for malignant transformation. There is no unanimity of opinion regarding the prognostic value of histopathologic dysplasia to forecast these outcomes. HPV is etiologically related to a subset of sinonasal papillomas and squamous carcinoma, and those with benign and malignant clinical course are separable on basis of HPV type. Because of the paucity of these nasal lesions, a multi-institutional prospective collaborative study is the ideal way to address these questions.

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

“…However, there was no significant survival benefit of elective neck dissection over the policy of waitand-watch/ observation/therapeutic neck dissection. [10,75,86]. The strong association between undifferentiated nasopharyngeal carcinoma and EBV is well known [47,59].…”

A high prevalence of human papillomavirus DNA in recurrent nasal papillomas

“…Among them, four (SO.OO/) of the five recurrent cases (cases 1-5) were HPV DNA-positive whereas only one (14.3%) of seven non-recurrent cases (cases [6][7][8][9][10][11][12] was HPV DNA-positive. The detection rate of HPV DNA in recurrent cases analysed by Fisher's exact probability test was significantly higher than that in non-recurrent cases (p = 0.045).…”

“…A clinical tendency for the lesion to recur even after adequate removal suggests the possibility of papillomas being induced by HPV Laryngeal papillomas are classified clinically into four groups: juvenile multiple, juvenile single, adult multiple and adult single [22]. HPV type 6/11 has been detected in almost 100% of juvenile and adult multiple laryngeal papillomas, strongly suggesting a viral aetiology for these benign tumors [23-251. Conversely, the reported prevalence of HPV in fungiform exophytic and inverted nasal papillomas has varied [l, [3][4][5][6][7][8][9][10][11][12][13]151. The methods and techniques used for detection of HPV as well as the patients' geographic location seem to influence the results.…”

Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An <i>in situ</i> hybridization study

“…The nature and pathogenesis of inverted papillomas are debated. Viral infections are one of the potential etiological factors [3][4][5][6][7][8]. It is well known that HPVs are the etiological agents responsible for a number of pathologies affecting the stratified epithelia of the skin and anogenital and oropharyngeal sites [9][10][11].…”