Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators

Park, Weon Seo; Ryu, Junsun; Cho, Kwan Ho; Choi, Moon Jung; Moon, Sung Ho; Yun, Tak; Chun, Byung–Sam; Lee, Geon Kook; Ahn, Hyun‐Joo; Lee, John H.; Vermeer, Paola D.; Jung, Yuh‐Seog

doi:10.1002/hed.21939

Cited by 32 publications

(32 citation statements)

References 19 publications

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“…The various cutoffs used for defining p16 overexpression have contributed to substantial variation in the level of concordance with direct HPV testing. The HPV and p16 concordance of our study is on the higher end (92%) among studies that employed the HPV DNA PCR approach (61-100%), but is similar to large studies (n > 100) with a defined p16 IHC cutoff of >50% (80-97% concordance) [17,22,[24][25][26][27][28][29]31,36,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. In a recent meta-analysis of OPSCC correlating HPV detected by DNA PCR and/or ISH and p16 (n = 2888), the highest correlation between HPV and p16 was for p16 IHC staining >70% rather than a verbal definition or a lower percentage.…”

Section: Discussionsupporting

confidence: 62%

“…The LAHPV test detects 37 high and low risk HPV types including all 12 types classified as carcinogenic (IARC Group 1: 16,18,31,33,35,39,45,51,52,56,58 and 59), the single type classified as probably carcinogenic (IARC Group 2A: 68), 7 types classified as possibly carcinogenic (IARC Group 2B: 26, 53, 66, 67, 70, 73 and 82) and 17 other types. All tests were run with manufacturer's positive and negative controls.…”

Section: Roche Linear Array Hpv Genotyping Test òmentioning

confidence: 99%

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Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

et al. 2015

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Section: Discussionsupporting

confidence: 62%

Section: Roche Linear Array Hpv Genotyping Test òmentioning

confidence: 99%

Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

et al. 2015

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“…20 The reasons for these increases in the number of oral and pharyngeal cancers and uterine cervical cancers after 2000 are unclear but may be related to the westernization of sexual habits. In other Asian countries, the p16-positive rate is reportedly 49.5% in Korea 21 and 29% in Hong Kong. 22 Multivariate analysis revealed a significant correlation between p16 expression and alcohol consumption and the clinical outcome of patients with OPSCC.…”

Section: Discussionmentioning

confidence: 93%

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Saito

Yoshida

Ushiku

et al. 2013

Cancer

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BACKGROUND:The prevalence and prognostic value of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) in Japan has not been evaluated. METHODS: Over a 12-year period, the authors used immunohistochemistry to evaluate the expression of p16 (a cyclin-dependent kinase inhibitor and tumor suppressor) in samples from 173 patients with OPSCC at a single institution and to determine its prevalence and influence on disease prognosis. RESULTS: The prevalence of p16-positive OPSCC was 33.7% in tonsillar carcinoma, 28.6% in tongue base carcinoma, 0% in posterior wall carcinoma, and 18.8% in soft palate carcinoma. The prevalence of p16-positive OPSCC tumors increased from 15.2% during 2000 to 2003 up to 33.3% during 2008 to 2011; during the same periods, among nonsmokers, the prevalence of p16-positive OPSCC tumors increased from 21.2% to 27.8%; and, among nondrinkers, prevalence increased from 6.1% to 25%. Multivariate analysis identified p16 expression and alcohol consumption as significant, independent prognostic markers of OPSCC. CONCLUSIONS: The current results suggest that the incidence of human papillomavirus-related OPSCC in Japan is increasing and indicate that p16 expression and alcohol consumption may be significant prognostic markers of survival for patients with OPSCC in Japan. Cancer 2013;119:2005-11. V C 2013 American Cancer Society.KEYWORDS: oropharyngeal carcinoma, head and neck squamous cell carcinoma, p16, human papillomavirus, alcohol consumption, Japan. INTRODUCTIONTobacco smoking and excessive alcohol consumption traditionally have been considered the main risk factors for head and neck squamous cell carcinoma (HNSCC). Oral and oropharyngeal squamous cell carcinoma (OPSCC) are major causes of morbidity, with an estimated annual worldwide incidence of 300,000. Evidence suggests that human papillomavirus (HPV) infection is also an independent risk factor, especially for OPSCC. [1][2][3][4][5][6] Most of the available data on HPVassociated SCC were generated in the United States and Europe. The incidence of HPV-associated malignancies, such as carcinoma of the uterine cervix, varies substantially in different regions of the world; for example, the incidence of HPVrelated cervical/uterine cancer is higher in African and Asian countries than in European countries. 7 Although eastern Asia, including Japan, is known for high epidemics of several oncogenic viral infections, such as Epstein-Barr virus and hepatitis B virus, the status of HPV-related SCC in Asia has not been elucidated.The diagnosis of HPV-related OPSCC can be made using polymerase chain reaction (PCR) analysis to detect HPV DNA 2 ; however, although this is a logical approach, it is quite challenging in clinical practice. Other diagnostic methods are HPV in situ hybridization or quantification of expression of the HPV oncoproteins E6 and E7, which has the major advantage of detecting transcriptionally active HPV. These assays, however, are cumbersome, costly, and require highly trained personnel. 8 A more feasible diagnos...

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“…Cohort studies from the 1990s suggested that approximately 50% of OSCC were associated with HPV, whereas more recent studies have suggested that HPV association may account for up to 70-80% of cases in North America and Europe [11,12]. In Asia, the prevalence has been reported to be 30-50% [13,14]. Therefore, a regional difference in the prevalence of HPV-associated OSCC exists.…”

Section: Discussionmentioning

confidence: 97%

“…In our retrospective study, the exact number of patients with a primary site in the oropharynx was unknown because some occult primary sites may have been controlled without detection because of the application of postoperative radiotherapy. However, this ratio was higher than that of p16 overexpression in Asian OSCC patients (30-50%) [13,14]. A presenting feature of HPV-associated OSCC is the abrupt appearance of an enlarged cervical lymph node and small primary lesion [17,18].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Human Papilloma Virus-Related Head and Neck Squamous Cell Carcinoma of an Unknown Primary Site

Kobayashi

Saito

Omura

et al. 2014

ORL

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Purpose: Head and neck squamous cell carcinoma of an unknown primary site (HNSCCUP) is a heterogeneous group of tumors that includes the human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. To investigate the relationship between HNSCCUP and HPV, we reviewed p16 overexpression and HPV DNA in lymph node metastases and examined their correlation with the primary site and clinical features. Materials and Methods: Thirty-three patients with HNSCCUP were retrospectively studied. Dissected neck metastases were analyzed for p16 overexpression by immunohistochemistry, and the presence of HPV DNA was investigated by in situ hybridization. Results: Of the 33 patients, 8 (24%) exhibited p16 overexpression. p16-positive lymph node metastases contained significantly more HPV DNA and were most frequently associated with occult primary lesions in the oropharynx and a favorable prognosis. Patients with a lower alcohol consumption, only level II/III metastasis, and cystic lymph node metastasis tended to have p16 overexpression. Conclusions: This is the first report on the relationship of HNSCCUP with p16 and HPV DNA status in Asian patients. In total, 24% of the HNSCCUP patients were p16 positive. p16 overexpression in neck metastasis was predictive of both an occult primary lesion in the oropharynx and an association with HPV infection. Alcohol consumption, location, and features of neck metastasis were correlated with p16 expression.

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Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators

Abstract: Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.

Cited by 32 publications

References 19 publications

Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Clinical Features of Human Papilloma Virus-Related Head and Neck Squamous Cell Carcinoma of an Unknown Primary Site

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