Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma

Acuña, Gabriela; Gomà, Montserrat; Temprana-Salvador, Jordi; García-Bragado, F.; Alós, Llúcia; Ordï, Jaume; Cardesa, Antonio; Nadal, Alfons

doi:10.1038/s41379-018-0188-2

Cited by 18 publications

(22 citation statements)

References 26 publications

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“…A variety of other names have also been attributed to this tumor category, such as undifferentiated carcinoma of nasopharyngeal type, undifferentiated carcinoma with lymphoid stroma, lymphoepithelioma and lymphoepithelial like carcinoma, as well as recent names like lymphoepithelial carcinoma (LEC). Recently, Acuna, Hammas and Kermani have highlighted the etiopathogenesis of the disease in the background of viral etiology [ 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Acuna has postulated an even lower actual incidence (0.06–0.2%). Micheau, MacMillan, Zbaren and Acuna have reported male predominance in their respective series [ 6 , 11 , 14 , 15 ]. In our cumulative series, the disease predominates in males (76%), with smoking and alcohol as major contributing factors.…”

Section: Discussionmentioning

confidence: 99%

“…Acuna has reported 6 out of 19 cases of LEC of the larynx with EBV positivity, contrary to its nasopharyngeal counterpart with a strong EBV association. Acuna has found HPV DNA to be positive in 50% of cases (four of type 16 and one of type 58) but none in hypopharyngeal carcinoma [ 11 ]. Our cumulative results have shown 20% of cases to be EBV related.…”

Section: Discussionmentioning

confidence: 99%

“…The result of the search was 36 studies, of which 8 were excluded due to descriptions of different histologies, while 7 were removed due to the presence of LECs in sites other than the larynx or hypopharynx. After a comprehensive review, 21 articles were identified in the English literature from 1968 to 2018 [ 1 , 2 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Clinical information, including demographics, tumor location (sub-site), presenting symptoms, treatment modalities, viral etiology, genetic mutations and survival status, were extracted ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

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Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Faisal

Hartenbach

Schratter

et al. 2020

Cancers

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(1) Background: Lymphoepithelial carcinoma of the hypopharynx and larynx is a rare tumor with fewer than 50 cases in the published literature. We present a literature review to discuss the clinical findings, viral or genetic associations, diagnostic challenges, histopathological findings and therapeutic aspects of the disease. (2) Methods: A comprehensive literature review was performed through MEDLINE/PubMed from 1968 to 2018. We identified 21 studies comprising 46 patients. Data on all the clinicopathological features, diagnostic modalities, treatment options and viral or genetic etiology were extracted and analyzed using SPSS. (3) Results: The mean age of presentation was 64 years (range 40–82 years) and mostly involved males. The supraglottis and pyriform sinus were the most commonly involved sub-sites, with surgery as the preferred treatment modality. The presence of the Epstein–Barr virus possibly directs a viral etiology. The incidence of cervical and distant metastasis was 54% and 21%, respectively. The median survival time was 30 months. (4) Conclusions: Lymphoepithelial carcinoma of the hypopharynx is an aggressive tumor with a strong predilection for regional and distant metastasis. Surgery, in combination with adjuvant therapy, provides promising results. Immunohistochemistry helps in differentiating LEC from other pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Faisal

Hartenbach

Schratter

et al. 2020

Cancers

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“…The etiopathogenesis of LEC is not fully clear, tobacco smoking and alcohol consumption are identified to be contributing factors for its development. Nasopharynx LEC is almost invariably associated with Epstein-Barr virus (EBV) infection, and human papillomavirus (HPV) has also been identified to link to LEC of the larynx, hypopharynx and oropharynx [5,6]. Previous studies demonstrated LEC has significant lymphocytic infiltration that could cause a strong immune response, thus, LEC patients were always accompanied with good prognosis [7,8].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and survival of lymphoepithelial carcinoma of the oral cavity and pharynx: a population-based study

Bai¹,

Zhao²,

S³

2019

Preprint

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Lymphoepithelial carcinoma (LEC) of the oral cavity and pharynx is uncommon, and the characteristics and survival remains unclear. The present study aims to describe the clinicopathological characteristics and determine the factors associated with survival of this uncommon cancer. A population-based study was carried out to investigate clinical characteristics and prognosis of LEC of the oral cavity and pharynx using the data from Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. The propensity-matched analysis was conducted for prognostic analysis, and a prognostic nomogram was also constructed. Totally, 1025 patients with LEC of the oral cavity and pharynx were identified, including 769 nasopharyngeal LEC patients and 256 non-nasopharyngeal LEC patients. The median OS of all LEC patients was 232.0m (95% CI 169.0-258.0). The 1-, 5-, 10-and 20-year survival rates were 92.9%, 72.9%, 59.3%, and 46.8%, respectively. Surgery could significantly prolong the survival time of LEC patients (P<0.01, mOS: 190m vs. 255m). Radiotherapy, as well as radiotherapy after surgery, could prolong the mOS (P<0.01 for both). The survival analysis demonstrated that old age (>60 years), lymph node (N3) and distant metastases were independent factors for poor survival, whereas radiotherapy and surgery were independent factors for favorable survival. No significant differences in survival time between nasopharyngeal LEC and non-nasopharyngeal LEC patients were observed. The prognostic nomogram was established base on five independent prognostic factors (C-index=0.70; 95% CI 0.66-0.74). In conclusion, LEC of the oral cavity and pharynx is a rare disease, and old age, lymph node and distant metastases, surgery and radiotherapy were significantly associated with prognosis. The prognostic nomogram could be used to make individual predictions of OS.

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Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis

Petruzzi

Costantino

Virgilio

et al. 2021

Eur Arch Otorhinolaryngol

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Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma

Cited by 18 publications

References 26 publications

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Lymphoepithelial Carcinoma of Larynx and Hypopharynx: A Rare Clinicopathological Entity

Clinicopathological characteristics and survival of lymphoepithelial carcinoma of the oral cavity and pharynx: a population-based study

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis

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