Human papillomavirus in Ethiopia

Derbie, Awoke; Mekonnen, Daniel; Yismaw, Gizachew; Biadglegne, Fantahun; Ostade, Xaveer Van; Abebe, Tamrat

doi:10.1007/s13337-019-00527-4

Cited by 13 publications

(18 citation statements)

References 31 publications

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“…As it is indicated in the table, HPV 16 is the most common genotype consistently reported globally as an important cause of cervical abnormalities. Variation in the other types of HPV genotype distribution across the above studies is likely attributable to differences in population, the severity of cervical lesions, age at screening initiation, frequency, coverage, and follow-up rates of women with cervical abnormalities [22,43]. Besides, the difference might also be associated with ethnic differences, geographical locations and the sexual behavior of their male partners [44][45][46].…”

Section: Discussionmentioning

confidence: 97%

“…These findings are essentially necessary to predict how HPV vaccination and HPV-based screening will impact cervical cancer prevention in Ethiopia. This infers that further HPV vaccine studies in Ethiopia should mainly target the first few predominant genotypes [22].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the high burden of cervical cancer related morbidity and mortality in Ethiopia, systematically compiled nationwide data on HPV genotypes distribution among Ethiopian women is limited. Therefore, this review was an update of our previous report [22] with more additional data describing the genotype distribution of HPVs in Ethiopia, where the finding would play a great role as an input for optimal vaccination and HPV-based cervical screening strategies.…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus genotype distribution in Ethiopia: an updated systematic review

Derbie

Mekonnen

Nibret

et al. 2022

Virol J

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Background Cervical cancer is caused by infection with high-risk human papillomaviruses (HR-HPVs). It is one of the leading causes of cancer-related deaths in Ethiopia and globally. To develop efficient vaccination and HPV-based cervical cancer screening approaches, data on genotype distribution of HPVs is crucial. Hence, the study was aimed to review HPV genotype distribution in Ethiopia. Methods Research articles were systematically searched using comprehensive search strings from PubMed/Medline and SCOPUS. Besides, Google Scholar was searched manually for grey literature. The last search was conducted on 18 August 2021. The first two authors independently appraised the studies for scientific quality and extracted the data using Excel sheet. The pooled HPV genotype distribution was presented with descriptive statistics. Results We have included ten studies that were reported from different parts of the country during 2005 and 2019. These studies included 3633 women presented with different kinds of cervical abnormalities, from whom 29 different HPV genotypes with a sum of 1926 sequences were reported. The proportion of high-risk, possible/probable high-risk and low-risk HPVs were at 1493 (77.5%), 182 (9.4%) and 195 (10.1%), respectively. Of the reported genotypes, the top five were HPV 16 (37.3%; 95% CI 35.2.1–39.5%), HPV 52 (6.8%; 95% CI 5.8–8.0%), HPV 35 (4.8%; 95% CI 3.9–5.8%), HPV 18 (4.4%; 95% CI 3.5–5.3%) and HPV 56 (3.9%: 95% CI 3.1–4.9%). Some of other HR-HPV groups include HPV 31 (3.8%), HPV 45 (3.5%), HPV 58 (3.1%), HPV 59(2.3%), and HPV 68 (2.3%). Among the high-risk types, the combined prevalence of HPV 16/18 was at 53.7% (95% CI 51.2–56.3%). HPV 11 (2.7%: 95% CI 2.1–3.5%), HPV 42 (2.1%: 95% CI 1.5–2.8%) and HPV 6 (2.1%: 95% CI 1.4–2.7%) were the most common low-risk HPV types. Conclusions We noted that the proportion of HR-HPV types was higher and HPV 16 in particular, but also HPV 52, HPV 35 and HPV 18, warrant special attention in Ethiopian’s vaccination and HPV based cervical screening program. Additional data from other parts of the country where there is no previous HPV genotype report are needed to better map the national HPV genotypes distribution of Ethiopia.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus genotype distribution in Ethiopia: an updated systematic review

Derbie

Mekonnen

Nibret

et al. 2022

Virol J

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“…The review conducted to estimate prevalence of HPV genotype among African women, including Ethiopia revealed that HPV16, 52,35,18,58,51,45,31,53, and 56 were the ten most common genotypes in the normal cervical cytology while HPV 16,18,35, and 52 were the four common types [56]. Another review from Ethiopian women depicted that HPV 16, 52, 18, 58, 45 were top five genotypes with the proportion of 45.3%, 9.4%, 8.2%, 6.9%, 5.2%, respectively [57]. Correspondingly, the pooled estimates of about 21 high risk HPV genotypes among HIV infected women were reported in this review with the estimated prevalence of genotype 16 (20%), 18 (15%), 52 (13%), 31 and 58 (11% each), 35 and 53 (10% each), 33, 51, and 66 (8% each), 45 (7%), and the remaining genotypes had the pooled estimate of less than seven percent.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of human papillomavirus among HIV infected women in developing countries: systematic review and meta-analysis

Bogale

Belay

Medhin

et al. 2020

Virol J

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Background Although, there is a variable burden of human papillomavirus (HPV) in women infected with HIV in developing countries, there are few studies that attempted to surmise such variable evidences. This review aimed to estimate the pooled prevalence of HPV genotype distribution and risk factors contributing to HPV infection among women infected with HIV in low- and middle-income countries. Methods We conducted a systematic review and meta-analysis of studies conducted in developing countries and reported HPV prevalence. We searched electronic databases: PubMed/Medline, SCOPUS, ScienceDirect, Excerpta Medical Database from Elsevier, Web of science, Cumulative Index of Nursing and allied Health Sciences and Google scholar databases to retrieve primary studies published in English language till 11th August 2019. We used random-effects model to estimate the pooled prevalence of HPV genotypes, and funnel plot to assess publication bias. The registration number of this review study protocol is CRD42019123549. Results We included nineteen studies with a total of 8,175 participants in this review. The prevalence of HPV was extremely heterogeneous across the studies (χ2= 3782.80, p value < 0.001, I2 = 99.6%). The estimated pooled prevalence of all HPV genotypes was 63.0% (95% CI: 48.0–78.0) while the pooled prevalence of high risk and low risk HPV genotypes were 51.0% (95% CI: 38.0–63.0) and 28.0% (95% CI: 12.0–43.0), respectively. The pooled prevalence of HPV genotype 16 was 20%, while genotype 18 and 52 were 15% and 13%, respectively. Different risk factors reported for HPV infection and the frequently reported were low CD4 count below 200 cells/mm3 and high HIV viral load. Conclusion The pooled prevalence of HPV among HIV infected women in low- and middle-income countries was considerable and the proportion of high risk HPV genotypes were high when compared with low risk genotypes. Therefore, it is essential for the HPV prevention program to prevent the double burden of HPV and HIV in women.

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“…High risk types of HPV (HPV-16, − 18, − 31, − 45) account for more than 90% of cervical carcinoma [ 15 ]. Human Papillomavirus (HPV) 16/18 prevalence among Ethiopian women has been estimated at 45.3%, highlighting the importance of secondary prevention in this population [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Uptake of cervical cancer screening service and associated factors among age-eligible women in Ethiopia: systematic review and meta-analysis

Ayenew

Zewdu

Nigussie

2020

Infect Agents Cancer

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Background Cervical cancer is the leading cause of cancer deaths among women in developing countries. Since cervical cancer is a preventable disease, screening is an important control and prevention strategy, recommended by the World Health Organization (WHO) for all women aged 30 years and older, and even earlier for some high-risk women. Therefore the aim of this study was to assess the uptake of cervical cancer screening among age-eligible women in Ethiopia. Method Review identification was performed through the search of online databases PubMed, Google Scholar, HINARI, EMBASE, Science Direct, Cochrane library, African Journals, and other gray and online repository accessed studies were searched using different search engines. For critical appraisal of studies, Newcastle-Ottawa Quality Assessment Scale (NOS) was used. The analysis was conducted by using STATA 11 software. To test the heterogeneity of studies, the Cochran Q test and I2 test statistics were used. To detect publication bias of the studies, the funnel plot and Egger’s test were used. The pooled prevalence of cervical cancer screening and the odds ratio (OR) with a 95% confidence interval were presented using forest plots. Result Twenty-four studies with a total of 14,582 age-eligible women were included in this meta-analysis. The pooled national level of cervical cancer screening among age-eligible women in Ethiopia was 13.46% (95%CI:11.06,15.86). Knowledge on cervical cancer and screening (OR = 4.01,95%CI:2.76,5.92), history of multiple sexual partners (OR = 5.01, 95%CI:2.61,9.61), women’s age (OR = 4.58, 95%CI:2.81,7.46), history of sexually transmitted disease (OR = 4.83,95%CI:3.02,7.73), Perceived susceptibility to cervical cancer (OR = 3.59, 95%CI:1.99,6.48), getting advice from health care providers (OR = 4.58, 95%CI:3.26, 6.43), women’s educational level (OR = 6.68,95%CI:4.61,9.68), women’s attitude towards cervical cancer and screening (OR = 3.42, 95%CI:2.88,4.06) were the determinant factors of cervical cancer screening uptake among age-eligible women in Ethiopia. Conclusion The pooled prevalence of cervical cancer screening was remarkably low among age-eligible women in Ethiopia. Thus, to increase the uptake of cervical cancer screening among age-eligible women regularly, it is better to create awareness programs for early detection and treatment of cervical cancer, and educational interventions that teach the step-by-step practice of cervical screening to increase women’s attitude for screening. Additionally, it is better to inform every woman is susceptible to cervical cancer, especially after starting sexual intercourse, and screening remains fundamental in the fight against cervical cancer before becoming invasive. Moreover, counseling and improving the confidence of women by health care providers to undergo screening is recommended.

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Human papillomavirus in Ethiopia

Cited by 13 publications

References 31 publications

Human papillomavirus genotype distribution in Ethiopia: an updated systematic review

Human papillomavirus genotype distribution in Ethiopia: an updated systematic review

Molecular epidemiology of human papillomavirus among HIV infected women in developing countries: systematic review and meta-analysis

Uptake of cervical cancer screening service and associated factors among age-eligible women in Ethiopia: systematic review and meta-analysis

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